Dunn, Claire, Brunetto, Maurizia, Reynolds, Gary, Christophides, Theodoros, Kennedy, Patrick T., Lampertico, Pietro, ...
Hepatitis B virus (HBV) causes chronic infection in more than 350 million people worldwide. It replicates in hepatocytes but is non-cytopathic; liver damage is thought to be immune mediated. Here, we...
Bim-mediated deletion of antigen-specific CD8+ T cells in patients unable to control HBV infection
Lopes, A. Ross, Kellam, Paul, Das, Abhishek, Dunn, Claire, Kwan, Antonia, Turner, Joanna, ...
HBV-specific CD8+ T cells are critical for a successful immune response to HBV infection. They are markedly diminished in number in patients who fail to control the virus, but the mechanisms...
Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
Das, Abhishek, Hoare, Matthew, Davies, Nathan, Lopes, A. Ross, Dunn, Claire, Kennedy, Patrick T.F., ...
The inflamed liver in chronic hepatitis B virus (HBV) infection (CHB) is characterized by a large influx of non–virus-specific CD8 T cells. Little is known about the functional capacity of these...