A. Sailer

Publication List Details

Period

1996 - 2008

Number

20

Co-Authors

Mice devoid of PrP are resistant to scrapie (2007)

Bueler, H., Aguzzi, A., Sailer, A., Greiner, R. A., Autenried, P., Aguet, M., ...

S.B. Prusiner proposed that the infectious agent of scraple, the prion, is PrPSc, a modified form of the normal host protein PrPC. Prn-p0/0 mice devoid of PrPC showed normal development and behavior....

PrP-deficient mice are resistant to scrapie (2007)

Weissmann, C., Bueler, H., Fischer, M., Sailer, A., Aguzzi, A., Aguet, M.

Prusiner proposed that the infectious agent of scrapie, the prion, is PrPSc, a modified form of the normal host protein PrPC. Prn-p0/0 mice devoid of PrPC showed normal development and behavior. When...

Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. (1999)

Raeber, A J, Sailer, A, Hegyi, I, Klein, M A, Rülicke, T, Fischer, M B, ...

The cellular form of the Prion protein (PrPC) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under the control of various cell- or...

The use of transgenic mice in the investigation of transmissible spongiform encephalopathies. (1998)

Weissmann, C, Fischer, M, Raeber, A, Bueler, H, Sailer, A, Shmerling, D, ...

The prion, the transmissible agent that causes spongiform encephalopathies such as scrapie, bovine spongiform encephalopathy and Creutzfeldt-Jakob disease, is believed to be devoid of nucleic acid...

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. (1997)

Raeber, A J, Race, R E, Brandner, S, Priola, S A, Sailer, A, Bessen, R A, ...

Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC. The exact cell types responsible for...

Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. (1996)

Brandner, S, Raeber, A, Sailer, A, Blättler, T, Fischer, M B, Weissmann, C, ...

Mice devoid of PrPC (Prnp%) are resistant to scrapie and do not allow propagation of the infectious agent (prion). PrPC-expressing neuroectodermal tissue grafted into Prnp% brains but not the...

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. (1996)

Fischer, M B, Rülicke, T, Raeber, A, Sailer, A, Moser, M, Oesch, B, ...

The 'protein only' hypothesis postulates that the prion, the agent causing transmissible spongiform encephalopathies, is PrP(Sc), an isoform of the host protein PrP(C). Protease treatment of prion...

Normal host prion protein necessary for scrapie-induced neurotoxicity. (1996)

Brandner, S, Isenmann, S, Raeber, A, Fischer, M B, Sailer, A, Kobayashi, Y, ...

Accumulation of the prion protein PrPSc, a pathological and protease-resistant isoform of the normal host protein PrPC, is a feature of prion disease such as scrapie. It is still unknown whether...

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

Fischer, M, Rülicke, T, Raeber, A, Sailer, A, Moser, M, Oesch, B, ...

The 'protein only' hypothesis postulates that the prion, the agent causing transmissible spongiform encephalopathies, is PrP(Sc), an isoform of the host protein PrP(C). Protease treatment of prion...

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.

Raeber, A J, Race, R E, Brandner, S, Priola, S A, Sailer, A, Bessen, R A, ...

Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC. The exact cell types responsible for...

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

Fischer, M, Rülicke, T, Raeber, A, Sailer, A, Moser, M, Oesch, B, ...

The 'protein only' hypothesis postulates that the prion, the agent causing transmissible spongiform encephalopathies, is PrP(Sc), an isoform of the host protein PrP(C). Protease treatment of prion...

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie.

Raeber, A J, Race, R E, Brandner, S, Priola, S A, Sailer, A, Bessen, R A, ...

Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC. The exact cell types responsible for...

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene.

Büeler, H., Raeber, A., Sailer, A., Fischer, M., Aguzzi, A., Weissmann, C.

BACKGROUND: It has been proposed that the prion, the infectious agent of transmissible spongiform encephalopathies, is PrPSc, a post-translationally modified form of the normal host protein PrPC. We...