Scientific Commons: A. Siegbahn

Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome. A GUSTO IV substudy (2003)

James, S.K., Armstrong, P., Barnathan, E., Califf, R., Lindahl, B., Siegbahn, A., ...

OBJECTIVES: We sought to evaluate C-reactive protein (CRP) and troponin T (TnT) as predictors of risk of the individual end points of mortality and myocardial infarction (MI) in a large cohort of...

Myocardial damage, inflammation and thrombin inhibition in unstable coronary artery disease (2003)

Oldgren, J, Wallentin, L, Grip, L, Linder, R, Nørgaard, B.L, Siegbahn, A

Aim Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors...

C5a receptor expression on leukocytes from patients with severe sepsis or septic shock (2001)

Furebring, M, Håkansson, L, Venge, P, Siegbahn, A, Nilsson, B, Sjölin, J

No abstract available.

The effect of a low molecular mass thrombin inhibitor, inogatran, and heparin on thrombin generation and fibrin turnover in patients with unstable coronary artery disease (1999)

Linder, R., Oldgren, J., Egberg, N., Grip, L., Larson, G., Siegbahn, A., ...

Aim This study evaluated a novel specific thrombin inhibitor, inogatran, in comparison with unfractionated heparin, with regard to markers for coagulation activity in patients with unstable coronary...

Activated partial thromboplastin time and clinical outcome after thrombin inhibition in unstable coronary artery disease (1999)

Oldgren, J., Linder, R., Grip, L., Siegbahn, A., Wallentin, L.

Aims Direct thrombin inhibitors have failed to prove superiority over unfractionated heparin in several clinical trials of unstable coronary artery disease. We have investigated the relationship...

Increased fibrinogen levels are associated with persistentChlamydia pneumoniaeinfection in unstable coronary artery disease (1998)

Toss, H., Gnarpe, J., Gnarpe, H., Siegbahn, A., Lindahl, B., Wallentin, L.

Aim Increased levels of acute phase proteins, e.g. fibrinogen, are related to a poor outcome in unstable coronary artery disease, but the cause of inflammation is unknown. We therefore investigated...

B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase.

Westermark, B, Siegbahn, A, Heldin, C H, Claesson-Welsh, L

Porcine aorta endothelial cells are devoid of receptors for platelet-derived growth factor (PDGF). We have transfected such cells with cDNA for the PDGF B-type receptor, both the wild-type receptor...

Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.

Siegbahn, A, Hammacher, A, Westermark, B, Heldin, C H

The chemotactic activities of three different isoforms of platelet-derived growth factor (PDGF) on fibroblasts, monocytes, and granulocytes of human origin were investigated. PDGF-AB and PDGF-BB...

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

Blume-Jensen, P, Siegbahn, A, Stabel, S, Heldin, C H, Rönnstrand, L

The product of the c-kit proto-oncogene, denoted Kit/SCF-R, encodes a tyrosine kinase receptor for stem cell factor (SCF). Kit/SCF-R induces proliferation, differentiation or migration of cells...

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Hansen, K, Johnell, M, Siegbahn, A, Rorsman, C, Engström, U, Wernstedt, C, ...

Ligand induced activation of the beta-receptor for platelet-derived growth factor (PDGF) leads to activation of Src family tyrosine kinases. We have explored the possibility that the receptor itself...

Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis.

Blume-Jensen, P, Claesson-Welsh, L, Siegbahn, A, Zsebo, K M, Westermark, B, Heldin, C H

The proto-oncogene c-kit is allelic with the murine white spotting (W) locus and encodes a transmembrane protein tyrosine kinase that is structurally related to the receptors for platelet-derived...

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

Eriksson, A, Siegbahn, A, Westermark, B, Heldin, C H, Claesson-Welsh, L

We have examined the signal transduction pathways of the PDGF alpha- and beta-receptors, in order to characterize the specificity of each receptor type in the signaling. Porcine aortic endothelial...