A. V. Gourine

On the peripheral and central chemoreception and control of breathing: an emerging role of ATP (2005)

Gourine, A.V.

Peripheral and central respiratory chemoreceptors are ultimately responsible for maintenance of constant levels of arterial PO2, PCO2 and [H+], protecting the brain from hypoxia and ensuring that the...

ATP is a mediator of chemosensory transduction in the central nervous system (2005)

Gourine, A.V., Llaudet, E., Dale, N., Spyer, K.M.

Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function1, 2, 3, 4, 5, 6, 7, 8. In the periphery, ATP mediates nociception3, 4, 5, mechanosensitivity3, 6,...

Release of ATP in the ventral medulla during hypoxia in rats: Role in hypoxic ventilatory response (2005)

Gourine, A.V., Llaudet, E., Nicholas, N., Spyer, K.M.

P2X2 receptor subunits of the ATP-gated ion channels are expressed by physiologically identified respiratory neurons in the ventral respiratory column, implicating ATP in the control of respiratory...

Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia (2003)

Rong, W., Gourine, A.V., Cockayne, D.A., Xiang, Z., Spyer, K.M., ...

In mammals, the ventilatory response to decreased oxygen tension in the arterial blood is initiated by excitation of specialized O2-sensitive chemoreceptor cells in the carotid body that release...

Purinergic signalling in the medullary mechanisms of respiratory control in the rat: respiratory neurones express the P2X2 receptor subunit (2003)

Gourine, A.V., Atkinson, L., Deuchars, J., Spyer, K.M.

ATP is involved in central respiratory control and may mediate changes in the activity of medullary respiratory neurones during hypercapnia, thus playing an important role in central chemoreception....