Moorman, A.V., Richards, S.M., Hancock, J.P., Mitchell, C.D., Vora, A.J., Harrison, C.J., ...
Although both MRD and karyotype are powerful determinants of outcome in childhood ALL, few studies have examined the kinetics of MRD clearance by cytogenetics. In ALL2003, patients are stratified by...
Russell, L.J., Akasaka, T., Majid, A., Sugimoto, K.J., Karran, E.L., Nagel, I., ...
Translocations involving the immunoglobulin heavy chain locus (IGH@) at chromosome band 14q32 are common in mature B-cell neoplasms, but are rare in B-cell precursor acute lymphoblastic leukemia...
Cytogenetic classification of T lineage acute lymphoblastic leukaemia (2007)
Harrison, C.J., Barber, K., Broadfield, Z., Stewart, A., Wright, S., Martineau, M., ...
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukaemia (2007)
Moorman, A.V., Harrison, CJ., Buck, G.A.N., Richards, S.M., Secker-Walker, L.M., Martineau, M., ...
Strefford, J.C., Worley, H., Barber, K., Wright, S., Stewart, A.R.M., Robinson, H.M., ...
Chromosomal abnormalities are important for the classification and risk stratification of patients with acute lymphoblastic leukemia (ALL). However, approximately 30% of childhood and 50% of adult...
Moorman, A.V., Richards, S.M., Robinson, H.M., Strefford, J.C., Gibson, B.E.S., Kinsey, S.E., ...
Patients with acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup. We prospectively screened 1630...
Strefford, J.C., Worley, H., Barber, K., Wright, S., Stewart, A.R.M., Robinson, H.M., ...
Chromosomal abnormalities are important for the classification and risk stratification of patients with acute lymphoblastic leukemia (ALL). However, approximately 30% of childhood and 50% of adult...
Disruption of PAX5 in patients with acute lymphoblastic leukaemia and dicentric chromosomes (2007)
An, Q., Wright, S.L., Konn, Z.J., Moorman, A.V., Harrison, C.J., Strefford, J.C.
Sanderson, R.N., Johnson, P.R., Moorman, A.V., Roman, E., Willett, E., Taylor, P.R., ...
Few large demographic studies of acute myeloid leukemia (AML) are derived from population-based registries. Demographic and karyotypic data were provided for AML cases from two regional leukemia...
PAX5-ETV6 fusion in acute lymphoblastic leukaemia does not define the dic(9;12) (2006)
Broadfield, Z., Martineau, M., Moorman, A.V., Wright, S.L., Bown, N., Harrison, C.J.
Moorman, A.V., Raimondi, S.C., Pui, C.H., Baruchel, A., Biondi, A., Carroll, A.J., ...
This study characterized the additional chromosomal abnormalities (ACA) associated with 11q23 rearrangements in 450 infants and children with acute lymphoblastic leukemia (ALL) and examined the...
Harrison, C.J., Moorman, A.V., Barber, K.E., Broadfield, Z.J., Cheung, K.L., Harris, R.L., ...
Interphase fluorescence in situ hybridization (iFISH) was used independently to reveal chromosomal abnormalities of prognostic importance in a large, consecutive series of children (n = 2367) with...
Robinson, H.M., Martineau, M., Harris, R.L., Barber, K.E., Jalali, G.R., Moorman, A.V., ...
Deletions from the derivative chromosome 9, der(9), of the translocation, t(9;22)(q34;q11), at the site of the ABL/BCR fusion gene, have been demonstrated by fluorescence in situ hybridisation...
Roy, A., Cargill, A., Love, S., Moorman, A.V., Stoneham, S., Lim, A., ...
A retrospective analysis of children with first relapse of acute lymphoblastic leukaemia (ALL), treated on the UKALL R2 protocol at four different hospitals, between June 1995 and December 2002 was...
Bowen, D.T., Frew, M.E., Hills, R., Gale, R.E., Wheatley, K., Groves, M.J., ...
The pathogenesis of acute myeloid leukemia (AML) involves the cooperation of mutations promoting proliferation/survival and those impairing differentiation. The RAS pathway has been implicated as a...
Fisher, A.M., Strike, P., Scott, C., Moorman, A.V.
From 5% to 10% of 9;22 translocations in chronic myeloid leukemia (CML) are reported to occur in variant form, that is, with the involvement of other regions of the genome in 3-way or more...
Correspondence. Amplification of the ABL gene in T-cell acute lymphoblastic leukemia (2004)
Barber, K.E., Martineau, M., Harewood, L., Stewart, M., Cameron, E., Strefford, J.C., ...
Harewood, L., Robinson, H., Harris, R., Al-Obaidi, M.J., Jalali, G.R., Martineau, M., ...
This study identifies multiple copies of the AML1 gene on a duplicated chromosome 21, dup(21), as a recurrent abnormality in acute lymphoblastic leukemia (ALL). Clusters of AML1 signals were visible...
Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome (2003)
Robinson, H.M., Broadfield, Z.J., Cheung, K.L., Harewood, L., Harris, R.L., Jalali, G.R., ...
A total of 28 children and nine adults with relapsed T-ALL were analyzed for the configuration of their T-cell receptor (TCR) and TAL1 genes at diagnosis and relapse to evaluate their stability...
Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia (2002)
Moorman, A.V., Roman, E., Cartwright, R.A., Morgan, G.J.
It is generally considered that most cancers arise following the accumulation of several genetic events and that as a consequence its incidence increases with age. We report a cytogenetic subgroup of...
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups (2002)
Moorman, A.V., Roman, E., Cartwright, R.A., Morgan, G.J.
Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities...
Lebailly, P., Willett, E.V., Moorman, A.V., Roman, E., Cartwright, R., Morgan, G.J., ...
Acute myeloid leukaemia (AML) cases with different chromosomal abnormalities may reflect different aetiologies. Benzene exposure, from a number of sources including smoking, is one risk factor for...
Allan, J.M., Wild, C.P., Rollinson, S., Willett, E.V., Moorman, A.V., Dovey, G.J., ...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human...
Allan, J.M., Wild, C.P., Rollinson, S., Willett, E.V., Moorman, A.V., Dovey, G.J., ...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human...
Allan, J.M., Wild, C.P., Rollinson, S., Willett, E.V., Moorman, A.V., Dovey, G.J., ...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human...
Allan, J.M., Wild, C.P., Rollinson, S., Willett, E.V., Moorman, A.V., Dovey, G.J., ...
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human...
Age-specific incidence rates for cytogenetically-defined subtypes of acute myeloid leukaemia
Moorman, A V, Roman, E, Cartwright, R A, Morgan, G J
It is generally considered that most cancers arise following the accumulation of several genetic events and that as a consequence its incidence increases with age. We report a cytogenetic subgroup of...
Smoking and the risk of acute myeloid leukaemia in cytogenetic subgroups
Moorman, A V, Roman, E, Cartwright, R A, Morgan, G J
Cytogenetically-defined subgroups of acute myeloid leukaemia have distinct biologies, clinical features and outcomes. Evidence from therapy-related leukaemia suggests that chromosomal abnormalities...