Scientific Commons: A. Wilk

The structure and dynamics of the spherical protein Apoferritin in aqueous solution are studied over a wide range of protein concentrations and ionic strengths. At high ionic strength and low protein...

Interparticle correlations due to electrostatic interactions: A small angle x-ray and dynamic light scattering study. I. Apoferritin (2002)

Häußler, W., Wilk, A., Gapinski, J., Patkowski, A.

The structure and dynamics of the spherical protein Apoferritin in aqueous solution are studied over a wide range of protein concentrations and ionic strengths. At high ionic strength and low protein...

The effect of two antipodal fluorine-induced sugar puckers on the conformation and stability of the Dickerson-Drew dodecamer duplex [d(CGCGAATTCGCG)]2 (1998)

Ikeda, H, Fernandez, R, Wilk, A, Barchi, JJ, Huang, X, Marquez, VE

Cleavage of oligodeoxyribonucleotides from controlled-pore glass supports and their rapid deprotection by gaseous amines (1996)

Boal, JH, Wilk, A, Harindranath, N, Max, EE, Kempe, T, Beaucage, SL

The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro (1993)

H. Tchorzewski, K. Zeman, J. Kantorski, E. Paleolog, M. Kahan, M. Feldmann, ...

Tumour necrosis factor-α (TNF-α) has been implicated as an important inflammatory mediator. In vitro, TNF-α is reported to activate human polymorphonuclear neutrophils (PMN), inducing responses...

Cleavage of oligodeoxyribonucleotides from controlled-pore glass supports and their rapid deprotection by gaseous amines.

Boal, J H, Wilk, A, Harindranath, N, Max, E E, Kempe, T, Beaucage, S L

A novel method for the deprotection of oligodeoxyribonucleotides has been developed. Gaseous amines such as ammonia or methylamine were employed under pressure to achieve mild and rapid deprotection...

The effect of two antipodal fluorine-induced sugar puckers on the conformation and stability of the Dickerson-Drew dodecamer duplex [d(CGCGAATTCGCG)]2.

Ikeda, H, Fernandez, R, Wilk, A, Barchi, J J, Huang, X, Marquez, V E

UV thermal melting studies, CD and NMR spectroscopies were employed to assess the contribution of antipodal sugar conformations on the stability of the canonical B-DNA conformation of the...

Analysis of oligo(deoxynucleoside phosphorothioate)s and their diastereomeric composition.

Wilk, A, Stec, W J

Short oligo(deoxynucleoside phosphorothioate)s were analyzed as a pool of individual diastereomeric species. The composition of such mixtures, determined by means of HPLC, indicates that consecutive...

The isopropoxyacetic group for convenient base protection during solid-support synthesis of oligodeoxyribonucleotides and their triester analogs.

Uznanski, B, Grajkowski, A, Wilk, A

Isopropoxyacetic anhydride was successfully used for protection of exoaminofunctions of 2'-deoxyadenosine, -guanosine and -cytidine. N-isopropoxyacetylated nucleosides are stable under the conditions...

Backbone-modified oligonucleotides containing a butanediol-1,3 moiety as a 'vicarious segment' for the deoxyribosyl moiety--synthesis and enzyme studies.

Wilk, A, Koziolkiewicz, M, Grajkowski, A, Uznanski, B, Stec, W J

Sequential single replacement of nucleosides within the decanucleotide d[GGGAATTCCC] (7) by means of a butanediol-1,3 residue allowed us to obtain a set of ten decanucleotides containing 'vicarious'...

Abasic oligodeoxyribonucleoside phosphorothioates: synthesis and evaluation as anti-HIV-1 agents.

Iyer, R P, Uznanski, B, Boal, J, Storm, C, Egan, W, Matsukura, M, ...

The syntheses and anti-HIV-1 evaluations of two, abasic oligodeoxyribonucleotide phosphorothioate analogs, d[Cps(Eps)26C] and d[Cps(Vps)26C] (where E and V derive from 1,2-dideoxy-D-ribofuranose and...

Complex structural behavior of oligopurine-oligopyrimidine sequence cloned within the supercoiled plasmid.

Parniewski, P, Galazka, G, Wilk, A, Klysik, J

Synthetic sequence GATCC(AG)7ATCG(AT)4CG(AG)7 was cloned into plasmid and its structural behavior under the influence of supercoiling was analysed by chemical modification at variety of experimental...

Dam methyltransferase sites located within the loop region of the oligopurine-oligopyrimidine sequences capable of forming H-DNA are undermethylated in vivo.

Parniewski, P, Kwinkowski, M, Wilk, A, Klysik, J

Several derivatives of pUC18 plasmid were constructed that contained oligopurine-oligopyrimidine (pur-pyr) motifs surrounded by Dam methylation sites. Inserts of two of the molecules (pPP1 and pPP2)...