ized Pharmacophore Identification for Drug Design (2007)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, A. Yao
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
Rapid: Randomized pharmacophore identification for drug design (1997)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
Rapid: randomized pharmacophore identi cation for drug design (1997)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for nding invariants in a set of exible and chemically distinct ligands (drug molecules) that underlies an integrated software system called RAPID currently...
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
Kavraki Latombe, P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
Finn Kavraki Latombe, P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, ...
This paper describes a randomized approach for finding invariants in a set of flexible and chemically distinct ligands (drug molecules) that underlies an integrated software system called RAPID...
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
Kavraki Latombe, P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
P. W. Finn, L.E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible ligands (drug molecules) that underlies an integrated software system called RAPID currently under development....
RAPID: Randomized Pharmacophore Identification for Drug Design (1997)
P. W. Finn, L. E. Kavraki, R. Motwani, C. Shelton, S. Venkatasubramanian, ...
This paper describes a randomized approach for finding invariants in a set of flexible and chemically distinct ligands (drug molecules) that underlies an integrated software system called RAPID...
Cellular aging, destabilization, and cancer.
Three major characteristics of aging in animals are a slowdown of cell proliferation, an increase in residual bodies associated with age pigments, and a marked increase in the likelihood of...
The role of heritable, population-wide cell damage in neoplastic development was studied in the 28 L subline of NIH 3T3 cells. These cells differ from the 17(3c) subline used previously for such...
Heritable, population-wide damage to cells as the driving force of neoplastic transformation.
Prolonged incubation of NIH 3T3 cells under the growth constraint of confluence results in the death of some cells in a manner suggestive of apoptosis. Successive rounds of prolonged incubation at...
Early passages of NIH 3T3 cells yield about 10 transformed foci for every 10(5) cells seeded after the cells multiply to confluence in a standardized 2-week assay. The question arose whether more...
A critical test of the role of population density in producing transformation.
Cells of the NIH 3T3 line gain the capacity to produce neoplastically transformed foci when they are maintained at high density for more than 1 week and transferred in a standard assay for focus...
Most human tumors are clonal in origin, although the cells may be diverse in their properties. Since the tumors evolve through progressive stages over decades of time, it is possible that the...
Early passages of the NIH 3T3 mouse cell line undergo spontaneous neoplastic transformation leading to the development of transformed foci if grown to confluence in 2% (vol/vol) calf serum (CS) and...
A subline of NIH 3T3 cells adapted to multiply in 0.25% calf serum (CS) by frequent passage (every 2-3 days) at low population density in 0.25% CS was deadapted by frequent successive passages of the...
Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity.
Cell transformation in culture is marked by the appearance of morphologically altered cells that continue to multiply to form discrete foci in confluent sheets when the surrounding cells are...
Yao, A, Takahashi, T, Aoyagi, T, Kinugawa, K, Kohmoto, O, Sugiura, S, ...
To investigate how cardiac myocytes recover from a brief period of ischemia, we used a metabolic inhibition (MI) model, one of the in vitro ischemic models, of chick embryo ventricular myocytes, and...
Cellular aging, destabilization, and cancer.
Three major characteristics of aging in animals are a slowdown of cell proliferation, an increase in residual bodies associated with age pigments, and a marked increase in the likelihood of...
The role of heritable, population-wide cell damage in neoplastic development was studied in the 28 L subline of NIH 3T3 cells. These cells differ from the 17(3c) subline used previously for such...
Heritable, population-wide damage to cells as the driving force of neoplastic transformation.
Prolonged incubation of NIH 3T3 cells under the growth constraint of confluence results in the death of some cells in a manner suggestive of apoptosis. Successive rounds of prolonged incubation at...
Early passages of NIH 3T3 cells yield about 10 transformed foci for every 10(5) cells seeded after the cells multiply to confluence in a standardized 2-week assay. The question arose whether more...
A critical test of the role of population density in producing transformation.
Cells of the NIH 3T3 line gain the capacity to produce neoplastically transformed foci when they are maintained at high density for more than 1 week and transferred in a standard assay for focus...
Most human tumors are clonal in origin, although the cells may be diverse in their properties. Since the tumors evolve through progressive stages over decades of time, it is possible that the...
Early passages of the NIH 3T3 mouse cell line undergo spontaneous neoplastic transformation leading to the development of transformed foci if grown to confluence in 2% (vol/vol) calf serum (CS) and...
A subline of NIH 3T3 cells adapted to multiply in 0.25% calf serum (CS) by frequent passage (every 2-3 days) at low population density in 0.25% CS was deadapted by frequent successive passages of the...
Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity.
Cell transformation in culture is marked by the appearance of morphologically altered cells that continue to multiply to form discrete foci in confluent sheets when the surrounding cells are...
Yao, A, Takahashi, T, Aoyagi, T, Kinugawa, K, Kohmoto, O, Sugiura, S, ...
To investigate how cardiac myocytes recover from a brief period of ischemia, we used a metabolic inhibition (MI) model, one of the in vitro ischemic models, of chick embryo ventricular myocytes, and...