Achim Göpferich

Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts, (2002)

Vogelhuber, Werner, Spruß, Thilo, Bernhardt, Günther, Buschauer, Armin, Göpferich, Achim

Nude mice were challenged with human U-87 MG glioblastoma tumors to assess the efficacy of different cytostatics and different application protocols. While the intraperitoneal application of BCNU...

Development and characterization of microencapsulated microspheres. (1994)

Göpferich, Achim, Alonso, Maria Jose, Langer, Robert S.

A process for the coating of polymer microspheres with the same or different polymers and the characterization of these particles is described. Coated microspheres were manufactured from degradable...

Drug delivery from bioerodible polymers: systemic and intravenous administration (1994)

Göpferich, Achim, Gref, Ruxandra, Minamitake, Yoshiharu, Shieh, Lisa, Alonso, Maria Jose, Tabata, Yashuhiko, ...

The recent progress in understanding the erosion of biodegradable polymers and the manufacturing of controlled release devices for proteins and peptides is reported. The erosion mechanism of...

Modeling of Polymer Erosion (1993)

Göpferich, Achim, Langer, Robert S.

The erosion of bioerodible polymers depends on many factors including the polymer chain length, bond cleavage velocity, swellability, crystallinity, and water diffusivity in the polymer matrix. This...

The Influence of Microstructure and Monomer Properties on the Erosion Mechanism of a Class of Polyanhydrides (1993)

Göpferich, Achim, Langer, Robert S.

The erosion of three different polyanhydrides consisting of sebacic acid (SA) and 1,3-bis(p-carboxyphenoxy) propane (CPP) was investigated. Melt cast polymer matrices were prepared from the...

Study of the in vitro penetration of the topical glucocorticoid betamethasone-17-valerate from solution-type gels into a multilayer membrane system. (1993)

Bendas, Barbara, Göpferich, Achim, Lee, Geoffrey, Neubert, R.

The in vitro transport of betamethasone-17-valerate (1) into a multilayer membrane system has been investigated. Subsaturated formulations of 1 were studied as formed by mixing appropriate propylene...

A Note on the Trandermal Delivery of Clenbuterol (1992)

Göpferich, Achim, Lee, Geoffrey

A modified diffusion/compartmental model has been used to simulate the transdermal uptake of clenbuterol from a matrix-type delivery device. The application of a fresh device every 7 days was found...

Determining the solubility and crystal form of clenbuterol in thin films of eudragit NE30D (1992)

Göpferich, Achim, Lee, Geoffrey

The solubility of the drug clenbuterol in thin films of surfactant-free Eudragit NE30D has been measured. Light microscopy and differential scanning calorimetry were supplemented by a technique based...

The influence of endogenous surfactant on the structure and drug-release properties of Eudragit NE30D-matrixes (1992)

Göpferich, Achim, Lee, Geoffrey

The influence of an endogenous surfactant present in Eudragit NE30D on the structure and drug release (clenbuterol) properties of thin matrices has been examined. Both drug-free and drug-loaded...

Measurement of drug diffusivity in stratum corneum membranes and a polyacrylate matrix (1991)

Göpferich, Achim, Lee, Geoffrey

Diffusivities have been determined for the drug clenbuterol for three non-sink, diffusional problems: diffusion out of a polymer matrix, diffusion through excised, human stratum corneum, and the...

An improved diffusion/compartmental model for transdermal drug delivery from a matrix-type device (1991)

Göpferich, Achim, Lee, Geoffrey

A mathematical model is presented for the description of transdermal drug delivery from a matrix-type delivery device. The model is partly diffusional and partly compartmental in nature. The matrix...