Achim Schnaufer

Association of Two Novel Proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA Editing Complex

Panigrahi, Aswini K., Gygi, Steven P., Ernst, Nancy L., Igo, Robert P., Palazzo, Setareh S., Schnaufer, Achim, ...

RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs. This occurs by a series of steps that are catalyzed by...

Four Related Proteins of the Trypanosoma brucei RNA Editing Complex

Panigrahi, Aswini K., Schnaufer, Achim, Carmean, Nicole, Igo, Robert P., Gygi, Steven P., Ernst, Nancy L., ...

RNA editing in kinetoplastid mitochondria occurs by a series of enzymatic steps that is catalyzed by a macromolecular complex. Four novel proteins and their corresponding genes were identified by...

Glucose is toxic to glycosome-deficient trypanosomes

Furuya, Tetsuya, Kessler, Peter, Jardim, Armando, Schnaufer, Achim, Crudder, Christopher, Parsons, Marilyn

Trypanosomatids, the etiologic agents of sleeping sickness, leishmaniasis, and Chagas' disease, compartmentalize glycolysis within glycosomes, metabolic organelles related to peroxisomes. Here, we...

Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene

Worthey, E. A., Martinez-Calvillo, Santiago, Schnaufer, Achim, Aggarwal, Gautam, Cawthra, Jason, Fazelinia, Gholam, ...

Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The ∼33.6 Mb genome is distributed among 36 chromosome...

SURVEY AND SUMMARY: Comparative analysis of editosome proteins in trypanosomatids

Worthey, Elizabeth A., Schnaufer, Achim, Mian, I. Saira, Stuart, Kenneth, Salavati, Reza

Detailed comparisons of 16 editosome proteins from Trypanosoma brucei, Trypanosoma cruzi and Leishmania major identified protein motifs associated with catalysis and protein or nucleic acid...

Identification of novel components of Trypanosoma brucei editosomes

PANIGRAHI, ASWINI K., SCHNAUFER, ACHIM, ERNST, NANCY L., WANG, BINGBING, CARMEAN, NICOLE, SALAVATI, REZA, ...

The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome...

The F1-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function

Schnaufer, Achim, Clark-Walker, G Desmond, Steinberg, Alodie G, Stuart, Ken

Survival of bloodstream form Trypanosoma brucei, the agent of African sleeping sickness, normally requires mitochondrial gene expression, despite the absence of oxidative phosphorylation in this...

Association of Two Novel Proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA Editing Complex

Panigrahi, Aswini K., Gygi, Steven P., Ernst, Nancy L., Igo, Robert P., Palazzo, Setareh S., Schnaufer, Achim, ...

RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs. This occurs by a series of steps that are catalyzed by...

Four Related Proteins of the Trypanosoma brucei RNA Editing Complex

Panigrahi, Aswini K., Schnaufer, Achim, Carmean, Nicole, Igo, Robert P., Gygi, Steven P., Ernst, Nancy L., ...

RNA editing in kinetoplastid mitochondria occurs by a series of enzymatic steps that is catalyzed by a macromolecular complex. Four novel proteins and their corresponding genes were identified by...

Glucose is toxic to glycosome-deficient trypanosomes

Furuya, Tetsuya, Kessler, Peter, Jardim, Armando, Schnaufer, Achim, Crudder, Christopher, Parsons, Marilyn

Trypanosomatids, the etiologic agents of sleeping sickness, leishmaniasis, and Chagas' disease, compartmentalize glycolysis within glycosomes, metabolic organelles related to peroxisomes. Here, we...

Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene

Worthey, E. A., Martinez-Calvillo, Santiago, Schnaufer, Achim, Aggarwal, Gautam, Cawthra, Jason, Fazelinia, Gholam, ...

Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The ∼33.6 Mb genome is distributed among 36 chromosome...

SURVEY AND SUMMARY: Comparative analysis of editosome proteins in trypanosomatids

Worthey, Elizabeth A., Schnaufer, Achim, Mian, I. Saira, Stuart, Kenneth, Salavati, Reza

Detailed comparisons of 16 editosome proteins from Trypanosoma brucei, Trypanosoma cruzi and Leishmania major identified protein motifs associated with catalysis and protein or nucleic acid...

The F1-ATP synthase complex in bloodstream stage trypanosomes has an unusual and essential function

Schnaufer, Achim, Clark-Walker, G Desmond, Steinberg, Alodie G, Stuart, Ken

Survival of bloodstream form Trypanosoma brucei, the agent of African sleeping sickness, normally requires mitochondrial gene expression, despite the absence of oxidative phosphorylation in this...

Identification of novel components of Trypanosoma brucei editosomes

PANIGRAHI, ASWINI K., SCHNAUFER, ACHIM, ERNST, NANCY L., WANG, BINGBING, CARMEAN, NICOLE, SALAVATI, REZA, ...

The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome...

An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei

Babbarwal, Vinod Kumar, Fleck, Michele, Ernst, Nancy Lewis, Schnaufer, Achim, Stuart, Kenneth

RNA editing in the sleeping sickness parasite Trypanosoma brucei remodels mitochondrial transcripts by the addition and deletion of uridylates as specified by guide RNAs. Editing is catalyzed by at...

KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei

Tarun, Salvador Zipagan, Schnaufer, Achim, Ernst, Nancy Lewis, Proff, Rosemary, Deng, Junpeng, Hol, Wim, ...

Most mitochondrial mRNAs in kinetoplastid protozoa require post-transcriptional RNA editing that inserts and deletes uridylates, a process that is catalyzed by multiprotein editosomes. KREPA6 is the...