Adam J. Gehring

HBV-Specific Adaptive Immunity (2009)

Antonio Bertoletti, Anthony T. Tan, Adam J. Gehring

The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature...

Immune evasion by Mycobacterium tuberculosis : mycobacterial lipoproteins exploit toll-like receptor-2 signaling to inhibit class-II MHC antigen processing / (2004)

Gehring, Adam J.

[School of Medicine] Department of Pathology.

The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2. (2003)

Gehring, Adam J., Rojas, Roxana E., Canaday, David H., Lakey, David L., Harding, Clifford V., Boom, W. Henry

Mycobacterium tuberculosis survives in macrophages in the face of acquired CD4(+) T-cell immunity, which controls but does not eliminate the organism. Gamma interferon (IFN-gamma) has a central role...

The Mycobacterium tuberculosis 19-Kilodalton Lipoprotein Inhibits Gamma Interferon-Regulated HLA-DR and FcγR1 on Human Macrophages through Toll-Like Receptor 2

Gehring, Adam J., Rojas, Roxana E., Canaday, David H., Lakey, David L., Harding, Clifford V., Boom, W. Henry

Mycobacterium tuberculosis survives in macrophages in the face of acquired CD4+ T-cell immunity, which controls but does not eliminate the organism. Gamma interferon (IFN-γ) has a central role in...

Modulation of the CD8+-T-Cell Response by CD4+ CD25+ Regulatory T Cells in Patients with Hepatitis B Virus Infection

Franzese, Ornella, Kennedy, Patrick T. F., Gehring, Adam J., Gotto, Jim, Williams, Roger, Maini, Mala K., ...

CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell...

The Mycobacterium tuberculosis 19-Kilodalton Lipoprotein Inhibits Gamma Interferon-Regulated HLA-DR and FcγR1 on Human Macrophages through Toll-Like Receptor 2

Gehring, Adam J., Rojas, Roxana E., Canaday, David H., Lakey, David L., Harding, Clifford V., Boom, W. Henry

Mycobacterium tuberculosis survives in macrophages in the face of acquired CD4+ T-cell immunity, which controls but does not eliminate the organism. Gamma interferon (IFN-γ) has a central role in...

Modulation of the CD8+-T-Cell Response by CD4+ CD25+ Regulatory T Cells in Patients with Hepatitis B Virus Infection

Franzese, Ornella, Kennedy, Patrick T. F., Gehring, Adam J., Gotto, Jim, Williams, Roger, Maini, Mala K., ...

CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell...

The Level of Viral Antigen Presented by Hepatocytes Influences CD8 T-Cell Function▿

Gehring, Adam J., Sun, Dianxing, Kennedy, Patrick T. F., Lim, Seng Gee, Wasser, Shanthi, ...

CD8 T cells exert their antiviral function through cytokines and lysis of infected cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance, CD8 T-cell antiviral...

Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire ▿ †

Tan, Anthony Tanoto, Loggi, Elisabetta, Boni, Carolina, Chia, Adeline, Gehring, Adam J., Sastry, Konduru S. R., ...

Repertoire composition, quantity, and qualitative functional ability are the parameters that define virus-specific T-cell responses and are linked with their potential to control infection. We took...