No abstract available.
Head & neck optical diagnostics: vision of the future of surgery (2009)
Upile, Tahwinder, Jerjes, Waseem, Sterenborg, Henricus JCM, El-Naggar, Adel K, Sandison, Ann, Witjes, Max JH, ...
Abstract Review paper and Proceedings of the Inaugural Meeting of the Head and Neck Optical Diagnostics Society (HNODS) on March 14 th 2009 at University College London. The aim of our research must...
Head & Neck Oncology: purpose, scope and goals-charting the future (2009)
El-Naggar, Adel K, Hopper, Colin, Upile, Tahwinder, Jerjes, Waseem
Abstract For many years now there has been a growing frustration with the statistics of head and neck cancer. Despite the many advances in diagnosis and therapy, there has been little change in the...
Chen, Xingming, Sturgis, Erich M., El-Naggar, Adel K., Wei, Qingyi, Li, Guojun
Because p53 and p73 are associated with critical cellular processes and can be inactivated or degraded by the human papillomavirus (HPV) E6 oncoprotein, we investigated the combined effects of p53...
Chen, Kexin, Hu, Zhibin, Wang, Li-E, Sturgis, Erich M., El-Naggar, Adel K., Zhang, Wei, ...
Tumor protein 53 (TP53), a transcriptional factor, induces expression of the B-cell lymphoma 2-associated X protein (BAX) gene by directly binding to the TP53-binding element in the BAX promoter but...
Li, Guojun, Sturgis, Erich M., Wang, Li-E., Chamberlain, Robert M., Amos, Christopher I., Spitz, Margaret R., ...
p73, a novel p53 homolog, has some p53-like activity and plays an important role in modulating cell-cycle control, apoptosis and cell growth. p73 regulates differentiation of head and neck squamous...
Izzo, Julie G., Papadimitrakopoulou, Vassiliki A., Liu, Diane D., Babenko, Ilona M., Keck, Jamie, ...
Background: Altered cyclin D1 expression in advanced preinvasive lesions of the upper aerodigestive tract (UADT) is associated with an increased risk of developing cancer and histologic progression...
p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas (2001)
El-Naggar, Adel K., Lai, Syeling, Clayman, Gary L., Mims, Betsy, Lippman, Scott M., Coombes, Madelene, ...
p73, a recently identified gene, maps to chromosome region 1p36.3, which is frequently deleted in a variety of solid tumors. Although the gene shares sequence and functional homologies with p53, its...
Adenovirus-Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer (1999)
Swisher, Stephen G., Roth, Jack A., Nemunaitis, John, Lawrence, David D., Kemp, Bonnie L., Carrasco, Cesar H., ...
BACKGROUND: Preclinical studies in animal models have demonstrated tumor regression following intratumoral administration of an adenovirus vector containing wild-type p53 complementary DNA (Ad-p53)....
Mao, Li, El-Naggar, Adel K., Papadimitrakopoulou, Vali, Shin, Dong M., Shin, Hyung C., Fan, Youhong, ...
Background: The goal of chemoprevention is to reduce the risk of cancer development by reversing or blocking the tumorigenic process through the use of pharmacologic or natural agents. To determine...
High metastatic potential in mice inheriting a targeted p53 missense mutation
Liu, Geng, McDonnell, Timothy J., Kapoor, Mini, Mims, Betsy, El-Naggar, Adel K., ...
To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in...
UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53
Jiang, Weidong, Ananthaswamy, Honnavara N., Muller, H. Konrad, Ouhtit, Allal, Bolshakov, Svetlana, Ullrich, Stephen E., ...
Epidemiological studies have suggested an association between exposure to solar UV radiation and the incidence of lymphoid malignancies, which has increased substantially worldwide during the last...
Mandal, Mahitosh, Younes, Maher, Swan, Eric A., Jasser, Samar A., Doan, Dao, Yigitbasi, Orhan, ...
Therapies that target signaling pathways critical to the pathogenesis and progression of squamous cell carcinoma of the head and neck (HNSCC) are needed. One such target, phosphatidylinositol...
Austin, John R., Cebrun, Hazel, Kershisnik, Mathew M., El-Naggar, Adel K., Garden, Adam S., DeMonte, Franco, ...
Updated information on the pathologic characterization and treatment of olfactory neurobiastoma (ON) and neuroendocrine carcinoma (NEC) diseases is presented. A series of patients with ON or NEC was...
High metastatic potential in mice inheriting a targeted p53 missense mutation
Liu, Geng, McDonnell, Timothy J., Kapoor, Mini, Mims, Betsy, El-Naggar, Adel K., ...
To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in...
UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53
Jiang, Weidong, Ananthaswamy, Honnavara N., Muller, H. Konrad, Ouhtit, Allal, Bolshakov, Svetlana, Ullrich, Stephen E., ...
Epidemiological studies have suggested an association between exposure to solar UV radiation and the incidence of lymphoid malignancies, which has increased substantially worldwide during the last...
Austin, John R., Cebrun, Hazel, Kershisnik, Mathew M., El-Naggar, Adel K., Garden, Adam S., DeMonte, Franco, ...
Updated information on the pathologic characterization and treatment of olfactory neurobiastoma (ON) and neuroendocrine carcinoma (NEC) diseases is presented. A series of patients with ON or NEC was...
In Vivo Expression of the Novel CXC Chemokine BRAK in Normal and Cancerous Human Tissue
Frederick, Mitchell J., Henderson, Ying, Xu, Xiaochun, Deavers, Michael T., Sahin, Aysegul A., Wu, Hong, ...
Using differential display, we cloned a gene with reduced expression in short-term explants of head and neck squamous cell carcinoma (HNSCC) tumors compared to cultured normal oral epithelial cells....
Loss of Retinoic Acid Receptor-β Expression Is an Early Event during Esophageal Carcinogenesis
Qiu, Hongming, Zhang, Wei, El-Naggar, Adel K., Lippman, Scott M., Lin, Peizhong, Lotan, Reuben, ...
We recently observed that growth inhibition of esophageal cancer cells by retinoic acid (RA) was associated with both constitutive expression and RA-induced up-regulation of RA receptor β (RAR-β)....
Slaton, Joel W., Inoue, Keiji, Perrotte, Paul, El-Naggar, Adel K., Swanson, David A., Fidler, Isaiah J., ...
We examined the expression levels of a number of metastasis-related genes to determine the relationship of these levels to the development of metastasis in renal cell carcinoma. Gene expression was...
Frierson, Henry F., El-Naggar, Adel K., Welsh, John B., Sapinoso, Lisa M., Su, Andrew I., Cheng, Jun, ...
Salivary gland cancers comprise a heterogeneous group of neoplasms whose biological and clinical characteristics differ considerably from those of mucosal squamous cell carcinomas of the head and...
p21 delays tumor onset by preservation of chromosomal stability
Barboza, Juan A., Liu, Geng, Ju, Zhenlin, El-Naggar, Adel K., Lozano, Guillermina
The p53 protein suppresses tumorigenesis by initiating cellular functions such as cell cycle arrest and apoptosis in response to DNA damage. A p53 mutant, p53R172P, which is deficient for apoptosis...
Maruya, Shin-ichiro, Kim, Hyung-Woo, Weber, Randal S., Lee, Jack J., Kies, Merril, Luna, Mario A., ...
Salivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis. The molecular events associated with their development and clinicopathological...
El-Naggar, Adel K., Mao, Li, Staerkel, Gregg, Coombes, Madelene M., Tucker, Susan L., Luna, Mario A., ...
We performed microsatellite analysis at chromosomal regions frequently altered in head and neck squamous carcinoma on matched saliva and tumor samples from 37 patients who had oral squamous...
Price, Nathan D., Trent, Jonathan, El-Naggar, Adel K., Cogdell, David, Taylor, Ellen, Hunt, Kelly K., ...
Gastrointestinal stromal tumor (GIST) has emerged as a clinically distinct type of sarcoma with frequent overexpression and mutation of the c-Kit oncogene and a favorable response to imatinib...
Enhanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms
Pollock, Raphael E., Lang, Aiquing, El-Naggar, Adel K., Radinsky, Robert, Hung, Mien Chie
Purpose. MDM2 is an oncogene whose protein product may promote tumorigenesis by blocking wild-type p53 tumor suppressor mediated G 0/G1 cell cycle arrest, thereby inhibiting repair of damaged DNA...
Head & Neck Oncology: purpose, scope and goals-charting the future
El-Naggar, Adel K, Hopper, Colin, Upile, Tahwinder, Jerjes, Waseem
For many years now there has been a growing frustration with the statistics of head and neck cancer. Despite the many advances in diagnosis and therapy, there has been little change in the prognosis...
Overexpression of Separase induces aneuploidy and mammary tumorigenesis
Zhang, Nenggang, Ge, Gouquing, Meyer, Rene, Sethi, Sumita, Basu, Dipanjan, Pradhan, Subhashree, ...
Separase is an endopeptidase that separates sister chromatids by cleaving cohesin Rad21 during the metaphase-to-anaphase transition. Conditional expression of Separase in tetracycline-inducible...
Lott, Steven T., Chen, Nanyue, Chandler, Dawn S., Yang, Qifeng, Wang, Luo, Rodriguez, Marivonne, ...
Ann Killary and colleagues describe a new gene that is genetically altered in breast tumors, and that may provide a new breast cancer prognostic marker.
Head & neck optical diagnostics: vision of the future of surgery
Upile, Tahwinder, Jerjes, Waseem, Sterenborg, Henricus JCM, El-Naggar, Adel K, Sandison, Ann, Witjes, Max JH, ...
Review paper and Proceedings of the Inaugural Meeting of the Head and Neck Optical Diagnostics Society (HNODS) on March 14th 2009 at University College London.
Chen, Xingming, Sturgis, Erich M., El-Naggar, Adel K., Wei, Qingyi, Li, Guojun
Because p53 and p73 are associated with critical cellular processes and can be inactivated or degraded by the human papillomavirus (HPV) E6 oncoprotein, we investigated the combined effects of p53...
Ye, Lei, Santarpia, Libero, Cote, Gilbert J., El-Naggar, Adel K., Gagel, Robert F.
Context: Activating mutations in the RET protooncogene have been demonstrated in multiple endocrine neoplasia 2 and sporadic medullary thyroid carcinoma (MTC). However, the complete genetic etiology...