Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway (2009)
Hazra, Aditi, Kraft, Peter, Lazarus, Ross, Chen, Constance, Chanock, Stephen J., Jacques, Paul, ...
Low plasma B-vitamin levels and elevated homocysteine have been associated with cancer, cardiovascular disease and neurodegenerative disorders. Common variants in FUT2 on chromosome 19q13 were...
Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk (2008)
Berndt, Sonja I., Potter, John D., Hazra, Aditi, Yeager, Meredith, Thomas, Gilles, Makar, Karen W., ...
Several different genetic variants at chromosome 8q24 have been related to prostate, breast and colorectal cancer risk with evidence of region-specific risk differentials for various tumor types. We...
Ogino, Shuji, Hazra, Aditi, Tranah, Gregory J., Kirkner, Gregory J., Kawasaki, Takako, Nosho, Katsuhiko, ...
O-6-methylguanine-DNA methyltransferase (MGMT) repairs inappropriately methylated guanine residues in DNA. MGMT promoter methylation and gene silencing are common events in colorectal cancer, and may...
Hazra, Aditi, Wu, Kana, Kraft, Peter, Fuchs, Charles S., Giovannucci, Edward L., Hunter, David J.
Dietary folate and alcohol consumption as well as polymorphic variants in one-carbon metabolism genes may modulate risk of colorectal adenoma through aberrant DNA methylation and altered nucleotide...
Genetic predictors of bladder cancer with an emphasis on methylation-related genes (2004)
Although tobacco exposure remains the prevailing risk factor for bladder cancer (BC), only a small percentage of exposed individuals develop cancer, suggesting that tobacco-related carcinogenesis is...