Adam Hampshire, Trevor W. Robbins, Adrian M. Owen, Roger A. Barker
Cognitive dysfunction commonly occurs even in the early stages of Parkinson’s disease (PD). Impairment on frontostriatally based executive tasks is particularly well described but affects only a...
Cognitive Dysfunction in Parkinson’s Disease: The Role of Frontostriatal Circuitry (2008)
Adrian M. Owen, Adrian M. Owen
It has been known for many years that the classic motor symptoms of Parkinson’s disease are accompanied by deficits of executive function that resemble those seen after frontal lobe damage in...
Attentional control in Parkinson's disease is dependent on COMT val158met genotype (2008)
Williams-Gray, Caroline H., Hampshire, Adam, Barker, Roger A., Owen, Adrian M.
Cognitive deficits occur even in the earliest stages of Parkinson's disease. Some such deficits are known to relate to dysfunction in dopaminergic frontostriatal networks, and may be influenced by a...
Do vegetative patients retain aspects of language comprehension? Evidence from fMRI (2007)
Coleman, Martin R., Rodd, Jennifer M., Davis, Matthew H., Johnsrude, Ingrid S., Menon, David K., Pickard, John D., ...
A diagnosis of vegetative state is made if a patient demonstrates no evidence of awareness of self or environment, no evidence of sustained, reproducible, purposeful or voluntary behavioural response...
Previous studies have indicated that the lateral prefrontal cortex (LPFC) is closely involved in strategic recoding, even when such processes lessen task demands. For example, 2 studies presented, in...
Fractionating Attentional Control Using Event-Related fMRI (2006)
Hampshire, Adam, Owen, Adrian M.
Despite numerous functional neuroimaging and lesion studies of human executive function, the precise neuroanatomical correlates of specific components of attentional control remain controversial....
Fractionating Attentional Control Using Event-Related fMRI (2006)
Hampshire, Adam, Owen, Adrian M.
Despite numerous functional neuroimaging and lesion studies of human executive function, the precise neuroanatomical correlates of specific components of attentional control remain controversial....
Previous studies have indicated that the lateral prefrontal cortex (LPFC) is closely involved in strategic recoding, even when such processes lessen task demands. For example, 2 studies presented, in...
Fractionating Attentional Control Using Event-Related fMRI (2006)
Hampshire, Adam, Owen, Adrian M.
Despite numerous functional neuroimaging and lesion studies of human executive function, the precise neuroanatomical correlates of specific components of attentional control remain controversial....
Previous studies have indicated that the lateral prefrontal cortex (LPFC) is closely involved in strategic recoding, even when such processes lessen task demands. For example, 2 studies presented, in...
Arana, F. Sergio, Parkinson, John A., Hinton, Elanor Clare, Holland, Anthony J., Owen, Adrian M., Roberts, Angela C.
Theories of incentive motivation attempt to capture the way in which objects and events in the world can acquire high motivational value and drive behavior, even in the absence of a clear biological...
Arana, F. Sergio, Parkinson, John A., Hinton, Elanor Clare, Holland, Anthony J., Owen, Adrian M., Roberts, Angela C.
Theories of incentive motivation attempt to capture the way in which objects and events in the world can acquire high motivational value and drive behavior, even in the absence of a clear biological...
Roshan Cools, Luke Clark, Adrian M. Owen, Trevor W. Robbins
Event-related functional magnetic resonance imaging was used to measure blood oxygenation level-dependent responses in 13 young healthy human volunteers during performance of a probabilistic...
Cools, Roshan, Stefanova, Elka, Barker, Roger A., Robbins, Trevor W., Owen, Adrian M.
This study examined the effects of l‐dopa medication in patients with Parkinson’s disease on cortical and subcortical blood flow changes during two tasks known to involve frontostriatal...
Dagher, Alain, Owen, Adrian M., Boecker, Henning, Brooks, David J.
Previous work has identified the prefrontal cortex (PFC) and striatum as participating in the planning and selection of movements. We compared the brain activation patterns during planning in...
Maintaining and Shifting Attention within Left or Right Hemifield (2000)
Vandenberghe, Rik, Duncan, John, Arnell, Karen M., Bishop, Sonia J., Herrod, Nicholas J., Owen, Adrian M., ...
Positron emission tomography (PET) was used to examine two questions: (i) which structures of the intact human brain change their activity with the direction of attention to left or right visual...
Dagher, Alain, Owen, Adrian M., Boecker, Henning, Brooks, David J.
We used the Tower of London task (TOL) and H215O-PET to map the network of brain structures involved in planning. Six healthy right-handed subjects had 12 measurements of relative regional cerebral...
Owen, Adrian M., Morris, Robin G., Sahakian, Barbara J., Polkey, Charles E., Robbins, Trevor W.
Thirty-two neurosurgical patients with unilateral or bilateral frontal lobe excisions, 41 patients with unilateral temporal lobe lesions and 19 patients who had undergone unilateral...
Owen, Adrian M., Evans, Alan C., Petrides, Michael
Previous work in nonhuman primates and in patients with frontal lobe damage has suggested that the frontal cortex plays a critical rolein the performance of both spatial and nonspatial working memory...
Owen, Adrian M., Roberts, Angela C., Hodges, John R., Robbins, Trevor W.
Tests which assess the ability to shift cognitive set modelled after the Wisconsin Card Sorting Test are particularly sensitive to impairments in patients with Parkinson's disease as well as in...
Owen, Adrian M., Stern, Chantal E., Look, Rodney B., Tracey, Irene, Rosen, Bruce R., Petrides, Michael
The present study used functional magnetic resonance imaging to demonstrate that performance of visual spatial and visual nonspatial working memory tasks involve the same regions of the lateral...
Owen, Adrian M., Stern, Chantal E., Look, Rodney B., Tracey, Irene, Rosen, Bruce R., Petrides, Michael
The present study used functional magnetic resonance imaging to demonstrate that performance of visual spatial and visual nonspatial working memory tasks involve the same regions of the lateral...
Dissociating speech perception and comprehension at reduced levels of awareness
Davis, Matthew H., Coleman, Martin R., Absalom, Anthony R., Rodd, Jennifer M., Johnsrude, Ingrid S., Matta, Basil F., ...
We used functional MRI and the anesthetic agent propofol to assess the relationship among neural responses to speech, successful comprehension, and conscious awareness. Volunteers were scanned while...
The Target Selective Neural Response — Similarity, Ambiguity, and Learning Effects
Hampshire, Adam, Thompson, Russell, Duncan, John, Owen, Adrian M.
A network of frontal and parietal brain regions is commonly recruited during tasks that require the deliberate ‘top-down’ control of thought and action. Previously, using simple target detection,...
Neural Correlates of Appetite and Hunger-Related Evaluative Judgments
Piech, Richard M., Lewis, Jade, Parkinson, Caroline H., Owen, Adrian M., Roberts, Angela C., Downing, Paul E., ...
How much we desire a meal depends on both the constituent foods and how hungry we are, though not every meal becomes more desirable with increasing hunger. The brain therefore needs to be able to...