Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling is important in both oncogenesis and development. Mathematical modeling predicts several unusual features of the Wnt pathway, some of which are tested experimentally.
Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Ethan Lee, Adrian Salic, Reinhart Heinrich, Marc W. Kirschner
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator b-catenin. Recent studies have...
Biochemical and developmental studies in the Wnt signaling pathway / (2000)
Thesis (Ph. D., Division of Medical Sciences (Cell and Developmental Biology))--Harvard University, 2000.
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Lee, Ethan, Salic, Adrian, Krüger, Roland, Heinrich, Reinhart, Kirschner, Marc W
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1
Pfleger, Cathie M., Salic, Adrian, Lee, Ethan, Kirschner, Marc W.
Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1....
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway
Lee, Ethan, Salic, Adrian, Krüger, Roland, Heinrich, Reinhart, Kirschner, Marc W
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator β-catenin. Recent studies have...
Inhibition of Cdh1–APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1
Pfleger, Cathie M., Salic, Adrian, Lee, Ethan, Kirschner, Marc W.
Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1....
Bub1 is essential for assembly of the functional inner centromere
Boyarchuk, Yekaterina, Salic, Adrian, Dasso, Mary, Arnaoutov, Alexei
During mitosis, the inner centromeric region (ICR) recruits protein complexes that regulate sister chromatid cohesion, monitor tension, and modulate microtubule attachment. Biochemical pathways that...
Physiological regulation of β-catenin stability by Tcf3 and CK1ε
Lee, Ethan, Salic, Adrian, Kirschner, Marc W.
The wnt pathway regulates the steady state level of β-catenin, a transcriptional coactivator for the Tcf3/Lef1 family of DNA binding proteins. We demonstrate that Tcf3 can inhibit β-catenin...
A chemical method for fast and sensitive detection of DNA synthesis in vivo
Salic, Adrian, Mitchison, Timothy J.
We have developed a method to detect DNA synthesis in proliferating cells, based on the incorporation of 5-ethynyl-2′-deoxyuridine (EdU) and its subsequent detection by a fluorescent azide through...
Exploring RNA transcription and turnover in vivo by using click chemistry
We describe a chemical method to detect RNA synthesis in cells, based on the biosynthetic incorporation of the uridine analog 5-ethynyluridine (EU) into newly transcribed RNA, on average once every...