Aidan Coffey

Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity (2009)

Josef Jampilek, Robert Musiol, Matus Pesko, Katarina Kralova, Marcela Vejsova, James Carroll, ...

In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using...

Investigating Biological Activity Spectrum for Novel Styrylquinazoline Analogues (2009)

Josef Jampilek, Robert Musiol, Jacek Finster, Matus Pesko, James Carroll, Katarina Kralova, ...

In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The...

Naturally Occurring Lactococcal Plasmid pAH90 Links Bacteriophage Resistance and Mobility Functions to a Food-Grade Selectable Marker

O' Sullivan, David, Ross, R. Paul, Twomey, Denis P., Fitzgerald, Gerald F., Hill, Colin, Coffey, Aidan

The bacteriophage resistance plasmid pAH90 (26,490 bp) is a natural cointegrate plasmid formed via homologous recombination between the type I restriction-modification specificity determinants (hsdS)...

Investigation of the Relationship between Lysogeny and Lysis of Lactococcus lactis in Cheese Using Prophage-Targeted PCR

O'Sullivan, David, Ross, R. Paul, Fitzgerald, Gerald F., Coffey, Aidan

The ability of lactococcal strains to lyse (and release intracellular enzymes) during cheese manufacture can be a very desirable trait and has been associated with improvement in flavor and...

Design of a Phage-Insensitive Lactococcal Dairy Starter via Sequential Transfer of Naturally Occurring Conjugative Plasmids

O’Sullivan, David, Coffey, Aidan, Fitzgerald, Gerald F., Hill, Colin, Ross, R. Paul

The plasmid-free Lactococcus lactis subsp. cremoris MG1614 is highly phage sensitive and lacks lactose fermenting ability (Lac) and primary casein degrading ability (Prt). Food grade gene transfer...

Variable Bacteriocin Production in the Commercial Starter Lactococcus lactis DPC4275 Is Linked to the Formation of the Cointegrate Plasmid pMRC02

Trotter, Maeve, McAuliffe, Olivia E., Fitzgerald, Gerald F., Hill, Colin, Ross, R. Paul, Coffey, Aidan

Lactococcus lactis DPC4275 is a bacteriocin-producing transconjugant of the industrial starter strain DPC4268. Strain DPC4275 was generated through conjugal transfer by mating DPC4268 with L. lactis...

Insertional Inactivation of Determinants for Mg2+ and Co2+ Transport as a Tool for Screening Recombinant Lactococcus Species Clones

Mills, Susan, Coffey, Aidan, Hill, Colin, Fitzgerald, Gerald F., McAuliffe, Olivia, Ross, R. Paul

Insertional inactivation of the plasmid-encoded determinants for Mg2+ and Co2+ transport, orf18/corA, provides a tool for screening recombinant clones in Lactococcus, based on the observation that...

Naturally Occurring Lactococcal Plasmid pAH90 Links Bacteriophage Resistance and Mobility Functions to a Food-Grade Selectable Marker

O' Sullivan, David, Ross, R. Paul, Twomey, Denis P., Fitzgerald, Gerald F., Hill, Colin, Coffey, Aidan

The bacteriophage resistance plasmid pAH90 (26,490 bp) is a natural cointegrate plasmid formed via homologous recombination between the type I restriction-modification specificity determinants (hsdS)...

Investigation of the Relationship between Lysogeny and Lysis of Lactococcus lactis in Cheese Using Prophage-Targeted PCR

O'Sullivan, David, Ross, R. Paul, Fitzgerald, Gerald F., Coffey, Aidan

The ability of lactococcal strains to lyse (and release intracellular enzymes) during cheese manufacture can be a very desirable trait and has been associated with improvement in flavor and...

Design of a Phage-Insensitive Lactococcal Dairy Starter via Sequential Transfer of Naturally Occurring Conjugative Plasmids

O’Sullivan, David, Coffey, Aidan, Fitzgerald, Gerald F., Hill, Colin, Ross, R. Paul

The plasmid-free Lactococcus lactis subsp. cremoris MG1614 is highly phage sensitive and lacks lactose fermenting ability (Lac) and primary casein degrading ability (Prt). Food grade gene transfer...

Variable Bacteriocin Production in the Commercial Starter Lactococcus lactis DPC4275 Is Linked to the Formation of the Cointegrate Plasmid pMRC02

Trotter, Maeve, McAuliffe, Olivia E., Fitzgerald, Gerald F., Hill, Colin, Ross, R. Paul, Coffey, Aidan

Lactococcus lactis DPC4275 is a bacteriocin-producing transconjugant of the industrial starter strain DPC4268. Strain DPC4275 was generated through conjugal transfer by mating DPC4268 with L. lactis...

Insertional Inactivation of Determinants for Mg2+ and Co2+ Transport as a Tool for Screening Recombinant Lactococcus Species Clones

Mills, Susan, Coffey, Aidan, Hill, Colin, Fitzgerald, Gerald F., McAuliffe, Olivia, Ross, R. Paul

Insertional inactivation of the plasmid-encoded determinants for Mg2+ and Co2+ transport, orf18/corA, provides a tool for screening recombinant clones in Lactococcus, based on the observation that...

Phage Lysin LysK Can Be Truncated to Its CHAP Domain and Retain Lytic Activity against Live Antibiotic-Resistant Staphylococci▿

Horgan, Marianne, O’Flynn, Gary, Garry, Jennifer, Cooney, Jakki, Coffey, Aidan, Fitzgerald, Gerald F., ...

A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical...