Aiming Sun

A target site for template-based design of measles virus entry inhibitors

Plemper, Richard K., Erlandson, Karl J., Lakdawala, Ami S., Sun, Aiming, Prussia, Andrew, Boonsombat, Jutatip, ...

Measles virus (MV) constitutes a principal cause of worldwide mortality, accounting for almost 1 million deaths annually. Although a live-attenuated vaccine protects against MV, vaccination...

Design of a Small-Molecule Entry Inhibitor with Activity against Primary Measles Virus Strains

Plemper, Richard K., Doyle, Joshua, Sun, Aiming, Prussia, Andrew, Cheng, Li-Ting, Rota, Paul A., ...

The incidence of measles virus (MV) infection has been significantly reduced in many nations through extensive vaccination; however, the virus still causes significant morbidity and mortality in...

Two Domains That Control Prefusion Stability and Transport Competence of the Measles Virus Fusion Protein

Doyle, Joshua, Prussia, Andrew, White, Laura K., Sun, Aiming, Liotta, Dennis C., Snyder, James P., ...

Most viral glycoproteins mediating membrane fusion adopt a metastable native conformation and undergo major conformational changes during fusion. We previously described a panel of compounds that...

A target site for template-based design of measles virus entry inhibitors

Plemper, Richard K., Erlandson, Karl J., Lakdawala, Ami S., Sun, Aiming, Prussia, Andrew, Boonsombat, Jutatip, ...

Measles virus (MV) constitutes a principal cause of worldwide mortality, accounting for almost 1 million deaths annually. Although a live-attenuated vaccine protects against MV, vaccination...

Design of a Small-Molecule Entry Inhibitor with Activity against Primary Measles Virus Strains

Plemper, Richard K., Doyle, Joshua, Sun, Aiming, Prussia, Andrew, Cheng, Li-Ting, Rota, Paul A., ...

The incidence of measles virus (MV) infection has been significantly reduced in many nations through extensive vaccination; however, the virus still causes significant morbidity and mortality in...

Two Domains That Control Prefusion Stability and Transport Competence of the Measles Virus Fusion Protein

Doyle, Joshua, Prussia, Andrew, White, Laura K., Sun, Aiming, Liotta, Dennis C., Snyder, James P., ...

Most viral glycoproteins mediating membrane fusion adopt a metastable native conformation and undergo major conformational changes during fusion. We previously described a panel of compounds that...

Nonnucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity▿ †

White, Laura K., Yoon, Jeong-Joong, Lee, Jin K., Sun, Aiming, Du, Yuhong, Fu, Haian, ...

Paramyxoviruses comprise several major human pathogens. Although a live-attenuated vaccine protects against measles virus (MV), a member of the paramyxovirus family, the virus remains a principal...