Molenaar, P, Chen, L, Semmler, ABT, Parsonage, WA, Kaumann, AJ
In atrium and ventricle from failing and non-failing human hearts, activation of beta(1)- or beta(2)-adrenoceptors causes increases in contractile force, hastening of relaxation, protein kinase...
Molenaar, P, Savarimuthu, SM, Sarsero, D, Chen, L, Semmler, ABT, Carle, A, ...
Activation of either coexisting beta(1)- or beta(2)-adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium. Previous...
Brattelid, T, Qvigstad, E, Lynham, JA, Molenaar, P, Aass, H, Geiran, O, ...
Serotonin (5-hydroxytryptamine, 5-HT) increases contractile force and elicits arrhythmias through 5-HT4 receptors in porcine and human atrium, but its ventricular effects are unknown. We now report...
Brattelid, T, Qvigstad, E, Lynham, JA, Molenaar, P, Aass, H, Geiran, O, ...
Serotonin (5-hydroxytryptamine, 5-HT) increases contractile force and elicits arrhythmias through 5-HT4 receptors in porcine and human atrium, but its ventricular effects are unknown. We now report...
Joseph, SS, Lynham, JA, Molenaar, P, Grace, AA, Colledge, WH, Kaumann, AJ
The beta-blocker (-)-pindolol produces intrinsic sympathomimetic activity manifested clinically by cardiostimulation, but the beta-adrenoceptor subtype, which mediates these effects, is unknown....
Joseph, SS, Lynham, JA, Molenaar, P, Grace, AA, Colledge, WH, Kaumann, AJ
The beta-blocker (-)-pindolol produces intrinsic sympathomimetic activity manifested clinically by cardiostimulation, but the beta-adrenoceptor subtype, which mediates these effects, is unknown....
Kaumann, AJ, Engelhardt, S, Hein, L, Molenaar, P, Lohse, M
Some beta (1)- and beta (2)-adrenoceptor-blocking agents, such as (-)-CGP 12177, cause cardiostimulant effects at concentrations considerably higher than those that antagonise the effects of...
Kaumann, AJ, Engelhardt, S, Hein, L, Molenaar, P, Lohse, M
Some beta (1)- and beta (2)-adrenoceptor-blocking agents, such as (-)-CGP 12177, cause cardiostimulant effects at concentrations considerably higher than those that antagonise the effects of...
Kaumann, AJ, Dawson, PJ, Molenaar, P, Burrell, KM
It is known that binding sites with endothelin(A) (ET)(A) and ETB receptor characteristics coexist in human heart but little is known about the receptors that mediate cardiostimulant effects of ET...
Sarsero, D, Molenaar, P, Kaumann, AJ
1 We have recently suggested the existence in the heart of a 'putative beta(4)-adrenoceptor' based on the cardiostimulant effects of non-conventional partial agonists, compounds that cause...
Kaumann, AJ, Preitner, F, Sarsero, D, Molenaar, P, Revelli, JP, Giacobino, JP
Some blockers of beta(1)- and beta(2)-adrenoceptors cause cardiostimulant effects through an atypical beta-adrenoceptor (putative beta(4)-adrenoceptor) that resembles the beta(3)-adrenoceptor. It is...
Sarsero, D, Molenaar, P, Kaumann, AJ
1 We have recently suggested the existence in the heart of a 'putative beta(4)-adrenoceptor' based on the cardiostimulant effects of non-conventional partial agonists, compounds that cause...
Kaumann, AJ, Preitner, F, Sarsero, D, Molenaar, P, Revelli, JP, Giacobino, JP
Some blockers of beta(1)- and beta(2)-adrenoceptors cause cardiostimulant effects through an atypical beta-adrenoceptor (putative beta(4)-adrenoceptor) that resembles the beta(3)-adrenoceptor. It is...
Molenaar, P, Sarsero, D, Arch, JRS, Kelly, J, Henson, SM, Kaumann, AJ
1 Chronic treatment of patients with beta-blockers causes atrial inotropic hyperresponsiveness through beta(2)-adrenoceptors, 5-HT4 receptors and H-2-receptors but apparently not through...
Modulation of human cardiac function through 4 beta-adrenoceptor populations (1997)
In human heart there is now evidence for the involvement of four beta-adrenoceptor populations, three identical to the recombinant beta(1)-, beta(2)- and beta(3)-adrenoceptors, and a fourth as yet...
Molenaar, P, Sarsero, D, Kaumann, AJ
1. Evidence for a 'putative beta(4)-adrenoceptor' originated over 20 years ago when cardiostimulant effects were observed to nonconventional partial agonists, These agonists were originally described...
Molenaar, P, Sarsero, D, Arch, JRS, Kelly, J, Henson, SM, Kaumann, AJ
1 Chronic treatment of patients with beta-blockers causes atrial inotropic hyperresponsiveness through beta(2)-adrenoceptors, 5-HT4 receptors and H-2-receptors but apparently not through...
Modulation of human cardiac function through 4 beta-adrenoceptor populations (1997)
In human heart there is now evidence for the involvement of four beta-adrenoceptor populations, three identical to the recombinant beta(1)-, beta(2)- and beta(3)-adrenoceptors, and a fourth as yet...
Molenaar, P, Sarsero, D, Kaumann, AJ
1. Evidence for a 'putative beta(4)-adrenoceptor' originated over 20 years ago when cardiostimulant effects were observed to nonconventional partial agonists, These agonists were originally described...