Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease (2008)
Rudy J. Castellani, Akihiko Nunomura, Raj K. Rolston, Paula I. Moreira, Atsushi Takeda, George Perry, ...
Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological...
Oxidative damage to RNA in neurodegenerative diseases. (2006)
Nunomura, Akihiko, Honda, Kazuhiro, Takeda, Atsushi, Hirai, Keisuke, Zhu, Xiongwei, Smith, Mark A., ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! (2006)
Lee, Hyoung-gon, Zhu, Xiongwei, Nunomura, Akihiko, Perry, George, Smith, Mark A.
Oxidative Damage to RNA in Neurodegenerative Diseases (2006)
Akihiko Nunomura, Kazuhiro Honda, Atsushi Takeda, Keisuke Hirai, Xiongwei Zhu, Mark A. Smith, ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Oxidative Damage to RNA in Neurodegenerative Diseases
Nunomura, Akihiko, Honda, Kazuhiro, Takeda, Atsushi, Hirai, Keisuke, Zhu, Xiongwei, Smith, Mark A., ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Oxidative Damage to RNA in Neurodegenerative Diseases
Nunomura, Akihiko, Honda, Kazuhiro, Takeda, Atsushi, Hirai, Keisuke, Zhu, Xiongwei, Smith, Mark A., ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Amyloid-β Vaccination: Testing the Amyloid Hypothesis? : Heads We Win, Tails You Lose!
Lee, Hyoung-gon, Zhu, Xiongwei, Nunomura, Akihiko, Perry, George, Smith, Mark A.
Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated τ, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
Castellani, Rudy J., Nunomura, Akihiko, Rolston, Raj K., Moreira, Paula I., Takeda, Atsushi, Perry, George, ...
Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological...
The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse
Lee, Hyoung-gon, Casadesus, Gemma, Nunomura, Akihiko, Zhu, Xiongwei, Castellani, Rudy J., Richardson, Sandy L., ...
Many different proteins associated with the cell cycle, including cyclins, cyclin-dependent kinases, and proto-oncogenes such as c-MYC (MYC), are increased in degenerating neurons. Consequently, an...