Akihiro Wada

Nitrite Reductase from Pseudomonas aeruginosa Released by Antimicrobial Agents and Complement Induces Interleukin-8 Production in Bronchial Epithelial Cells

Sar, Borann, Oishi, Kazunori, Wada, Akihiro, Hirayama, Toshiya, Matsushima, Kouji, Nagatake, Tsuyoshi

We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa, could induce interleukin-8 (IL-8) generation in a variety of...

Activation of Intercellular Adhesion Molecule 1 Expression by Helicobacter pylori Is Regulated by NF-κB in Gastric Epithelial Cancer Cells

Mori, Naoki, Wada, Akihiro, Hirayama, Toshiya, Parks, Thomas P., Stratowa, Christian, Yamamoto, Naoki

Interactions between leukocytes and epithelial cells may play a key role in Helicobacter pylori-associated gastric mucosal inflammation. This process is mediated by various cell adhesion molecules....

Induction of Monocyte Chemoattractant Protein 1 by Helicobacter pylori Involves NF-κB

Mori, Naoki, Ueda, Atsuhisa, Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Yoshimura, Teizo, ...

Helicobacter pylori stimulates secretion of monocyte chemoattractant protein 1 (MCP-1) from gastric epithelial cells. Secretion of this chemokine may be instrumental in monocyte infiltration of the...

ADP ribosylation of human neutrophil peptide-1 regulates its biological properties

Paone, Gregorino, Wada, Akihiro, Stevens, Linda A., Matin, Abul, Hirayama, Toshiya, Levine, Rodney L., ...

In human airways, epithelial cells lining the lumen and intraluminal cells (e.g., polymorphonuclear cells) participate in the innate immune response. These cells secrete or express on their surfaces...

Helicobacter pylori Induces RANTES through Activation of NF-κB

Mori, Naoki, Krensky, Alan M., Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Sasakawa, Chihiro, ...

Helicobacter pylori-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells and neutrophils. RANTES (short for “regulated upon activation, normal T cell expressed and...

Dynamin is involved in human epithelial cell vacuolation caused by the Helicobacter pylori–produced cytotoxin VacA

Suzuki, Junko, Ohnsihi, Hirohide, Shibata, Hiroshi, Wada, Akihiro, Hirayama, Toshiya, Iiri, Taroh, ...

The Helicobacter pylori–produced cytotoxin VacA induces intracellular vacuolation. To elucidate the molecular mechanism of vacuole formation by VacA, we examined the participation of dynamin, a...

Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells

Yokoyama, Kazuyuki, Higashi, Hideaki, Ishikawa, Susumu, Fujii, Yumiko, Kondo, Satoshi, Kato, Hiroyuki, ...

Chronic infection with cagA-positive Helicobacter pylori is associated with the development of atrophic gastritis, peptic ulcers, and gastric adenocarcinoma. The cagA gene product CagA is injected...

Nitrite Reductase from Pseudomonas aeruginosa Released by Antimicrobial Agents and Complement Induces Interleukin-8 Production in Bronchial Epithelial Cells

Sar, Borann, Oishi, Kazunori, Wada, Akihiro, Hirayama, Toshiya, Matsushima, Kouji, Nagatake, Tsuyoshi

We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa, could induce interleukin-8 (IL-8) generation in a variety of...

Activation of Intercellular Adhesion Molecule 1 Expression by Helicobacter pylori Is Regulated by NF-κB in Gastric Epithelial Cancer Cells

Mori, Naoki, Wada, Akihiro, Hirayama, Toshiya, Parks, Thomas P., Stratowa, Christian, Yamamoto, Naoki

Interactions between leukocytes and epithelial cells may play a key role in Helicobacter pylori-associated gastric mucosal inflammation. This process is mediated by various cell adhesion molecules....

Induction of Monocyte Chemoattractant Protein 1 by Helicobacter pylori Involves NF-κB

Mori, Naoki, Ueda, Atsuhisa, Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Yoshimura, Teizo, ...

Helicobacter pylori stimulates secretion of monocyte chemoattractant protein 1 (MCP-1) from gastric epithelial cells. Secretion of this chemokine may be instrumental in monocyte infiltration of the...

ADP ribosylation of human neutrophil peptide-1 regulates its biological properties

Paone, Gregorino, Wada, Akihiro, Stevens, Linda A., Matin, Abul, Hirayama, Toshiya, Levine, Rodney L., ...

In human airways, epithelial cells lining the lumen and intraluminal cells (e.g., polymorphonuclear cells) participate in the innate immune response. These cells secrete or express on their surfaces...

Helicobacter pylori Induces RANTES through Activation of NF-κB

Mori, Naoki, Krensky, Alan M., Geleziunas, Romas, Wada, Akihiro, Hirayama, Toshiya, Sasakawa, Chihiro, ...

Helicobacter pylori-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells and neutrophils. RANTES (short for “regulated upon activation, normal T cell expressed and...

Dynamin is involved in human epithelial cell vacuolation caused by the Helicobacter pylori–produced cytotoxin VacA

Suzuki, Junko, Ohnsihi, Hirohide, Shibata, Hiroshi, Wada, Akihiro, Hirayama, Toshiya, Iiri, Taroh, ...

The Helicobacter pylori–produced cytotoxin VacA induces intracellular vacuolation. To elucidate the molecular mechanism of vacuole formation by VacA, we examined the participation of dynamin, a...

Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells

Yokoyama, Kazuyuki, Higashi, Hideaki, Ishikawa, Susumu, Fujii, Yumiko, Kondo, Satoshi, Kato, Hiroyuki, ...

Chronic infection with cagA-positive Helicobacter pylori is associated with the development of atrophic gastritis, peptic ulcers, and gastric adenocarcinoma. The cagA gene product CagA is injected...

Clustering of Helicobacter pylori VacA in Lipid Rafts, Mediated by Its Receptor, Receptor-Like Protein Tyrosine Phosphatase β, Is Required for Intoxication in AZ-521 Cells▿

Nakayama, Masaaki, Hisatsune, Jyunzo, Yamasaki, Eiki, Nishi, Yoshito, Wada, Akihiro, Kurazono, Hisao, ...

Helicobacter pylori vacuolating cytotoxin, VacA, induces multiple effects on epithelial cells through different cellular events: one involves pore formation, leading to vacuolation, mitochondrial...