Akira Ito

Fabrication of complex three-dimensional tissue architectures using a magnetic force-based cell patterning technique (2009)

Akiyama, Hirokazu, Ito, Akira, Kawabe, Yoshinori, Kamihira, Masamichi

We describe the fabrication of three-dimensional tissue constructs using a magnetic force-based tissue engineering technique, in which cellular organization is controlled by magnetic force. Target...

Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy (2009)

Tomoaki Takada, Toshiharu Yamashita, Makito Sato, Akiko Sato, Ichiro Ono, Yasuaki Tamura, ...

Melanogenesis substrate, N-propionyl-cysteaminylphenol (NPrCAP), is selectively incorporated into melanoma cells and inhibits their growth by producing cytotoxic free radicals. Magnetite...

Paragonimiasis in Cameroon: molecular identification, serodiagnosis and clinical manifestations (2009)

Nkouawa, Agathe, Okamoto, Munehiro, Mabou, Alida Kouojip, Edinga, Eulodie, Yamasaki, Hiroshi, Sako, Yasuhito, ...

Paragonimiasis is a common parasitic zoonosis in Cameroon and neighbouring countries in Western Africa. Serum, sputum and faecal samples were collected in an endemic area of South West Province,...

Gelatinase (MMP-2 and -9) expression profiles during gestation in the bovine endometrium (2008)

Kizaki, Keiichiro, Ushizawa, Koichi, Takahashi, Toru, Yamada, Osamu, Todoroki, Junichi, Sato, Takashi, ...

Abstract Background Various molecules participate in implantation and maintaining endometrial function during gestation. The remodeling of endometrial matrices is a necessary process in the...

Abstract Recursive Object-Oriented Modules (2008)

Keiko Nakata, Akira Ito, Jacques Garrigue

ML-style modules and classes are complementary. The former are better at structuring and genericity, the latter at extension and mutual recursion. We investigate the convergence of both mechanisms by...

Semantic Interpretation Of A Japanese Complex Sentence In An Advisory Dialogue (2007)

Focused On, Tadahiko Kumamoto, Akira Ito

We are developing a spoken dialogue system that helps a computer user perform his tasks through question-answering. In this paper, we propose a method for semantic interpretation of a complex...

SEMANTIC INTERPRETATION OF A JAPANESE COMPLEX SENTENCE IN AN ADVISORY DIALOGUE--- Focused on the Postpositional Word "KEDO," Which Works as a Conjunction Between Clauses--- (2007)

Tadahiko Kumamoto, Akira Ito

We are developing a spoken dialogue system that helps a computer user perform his tasks through question-answering. In this paper, we propose a method for semantic interpretation of a complex...

Communicating Robots (2007)

Akira Ito, Hideki Kozima

Hitherto artificial communication systems have been manufactured based on the code model--- the model which assumes the sharing of communication protocols or "codes " among...

Estimating the time between drinking and death from tissue distribution patterns of ethanol. (2007)

Ito, Akira, Moriya, Fumio, Ishizu, Hideo

To establish a method for estimating the time between the last consumption of alcohol and death, we examined the ethanol levels in body fluids and tissues of rats that had been orally administered 1...

Analytical Evaluation of Analog Component Effects on AMC Performance in HSDPA System (2007)

SHIMIZU, Masahiko, ITO, Akira

We analytically evaluated the effects of the analog components on a high-speed downlink packet access (HSDPA) system standardized by 3GPP. We considered the phase noise of synthesizers, the imbalance...

Development of Cucumber mosaic virus as a vector modifiable for different host species to produce therapeutic proteins. (2007)

Matsuo, Kouki, Hong, Jin- Sung, Tabayashi, Noriko, Ito, Akira, Masuta, Chikara, Matsumura, Takeshi

We have developed Cucumber mosaic virus (CMV) as a plant virus vector especially for production of pharmaceutical proteins. The CMV vector is a vector modifiable for different host plants and does...

『ヴァージニア・ウルフなんかこわくない』と『埋められた子供』にみるアメリカン・ファミリー (2006)

伊藤, 章, Ito, Akira

The central subject of American drama is the American family. From Royall Tyler’s colonial comedy The Contrast (1787) to August Wilson’s King Hedley II (2000), relationships between husbands,...

Community surveys and risk factor analysis of human alveolar and cystic echinococcasis in Ningxia Hui Autonomous Region, China (2006)

Yang, Yu Rong, Sun,Tao, Li, Zhengzhi, Zhang, Jianzhong, Teng, Jing, Liu, Xongzhou, ...

Objective To determine the true community prevalence of human cystic (CE) and alveolar (AE) echinococcosis (hydatid disease) in a highly endemic region in Ningxia Hui, China, by detecting...

Community surveys and risk factor analysis of human alveolar and cystic echinococcasis in Ningxia Hui Autonomous Region, China (2006)

Yang, Yu Rong, Sun,Tao, Li, Zhengzhi, Zhang, Jianzhong, Teng, Jing, Liu, Xongzhou, ...

Objective To determine the true community prevalence of human cystic (CE) and alveolar (AE) echinococcosis (hydatid disease) in a highly endemic region in Ningxia Hui, China, by detecting...

Unique Family Clustering of Human Echinococcosis cases in a Chinese Community (2006)

Yang, Yu Rong, Ellis, Magda, Sun, Tao, Li, Zhengzhi, Liu, Xongzhou, Vuitton, Dominique A,, ...

We have identified a significant focus and unusual clustering of human cases of cystic echinococcosis (CE) and alveolar echinococcosis (AE) in the village of Nanwan, Xiji County, Ningxia Hui...

Simultaneous Alveolar and Cystic Echinococcosis of the Liver (2006)

Yang, Yu Rong, Liu, Xong Zhou, Vuitton, Dominique A., Bartholomot, Brigitte, Wang, Yun Hai, Ito, Akira, ...

Alveolar echinococcosis (AE) and cystic echinococcosis (CE), caused by infection with the larval stages of Echinococcus multilocularis and E. granulosus, respectively, are of major clinical...

Inkdot versus Pebble over Two-Dimensional Languages (2005)

INOUE, Atsuyuki, ITO, Akira, HIRAISHI, Kunihiko, INOUE, Katsushi

This paper investigates a relationship between inkdot and one-pebble for two-dimensional finite automata (2-fa's). Especially we show that (1) alternating inkdot 2-fa's are more powerful than...

Three-Way Two-Dimensional Deterministic Finite Automata with Rotated Inputs (2005)

HIRAKAWA, Hisao, INOUE, Katsushi, ITO, Akira

Inoue et al. introduced an automaton on a two-dimensional tape, which decides acceptance or rejection of an input tape by scanning the tape from various sides by various automata which move one way,...

Path-Bounded One-Way Multihead Finite Automata (2005)

INOUE, Satoshi, INOUE, Katsushi, ITO, Akira, WANG, Yue

For each positive integer r ≥ 1, a nondeterministic machine M is r path-bounded if for any input word x, there are r computation paths of M on x. This paper investigates the accepting powers of...

A Scene-based Model of Word Prediction (2004)

Hideki Kozima, Akira Ito

. This paper proposes a semantico-statistical model of word prediction which uses local context of each scene in a text. Scenes are text segments, each of which displays local context. The occurrence...

The Mitochondrial Genome of the Tapeworm Taenia solium: A Finding of the Abbreviated Stop Codon U (2003)

Minoru Nakao, Yasuhito Sako, Akira Ito

The complete nucleotide sequence of the tapeworm Taenia solium mitochondrial DNA (mtDNA) has been determined. The sequence is 13,709 base pairs in length and contains 36 genes (12 for proteins...

Differential Regulation of the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases by Cytokines and Growth Factors in Bovine Endometrial Stromal Cells and Trophoblast Cell Line BT-1 In Vitro1 (2003)

Michiko Hirata, Takashi Sato, Michiko Tsumagari, Arata Shimada, Haruo Nakano, Kazuyoshi Hashizume, ...

Degradation and reconstitution of extracellular matrix in uterine endometrium is a crucial event for embryonic implantation and is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors...

Cellular Immune Responses in Chickens Induced by Recombinant R7 Leucocytozoon caulleryi Vaccine (2003)

Kaoru Nakata, Shinobu Watarai, Hiroshi Kodama, Tohru Gotanda, Akira Ito, Katsumi Kume

We have recently developed recombinant subunit vaccine consisting of second-generation schizont (2GS) membrane protein (rR7) of Leucocytozoon caulleryi. Chickens immunized with rR7 antigen acquired...

Light Microscopical Observation of Infraciliary Bands of Eodinium posterovesiculatum in Comparison with Entodinium bursa and Diplodinium dentatum (2003)

AKIRA ITO, SOICHI IMAI

Morphological features of the four morphotypes of the rumen ciliate, Eodinium posterovesiculatum, are described from pyridinated silver carbonate-impregnated specimens. Infraciliary bands are...

Electrochemical Formation of Self-Assembled InP Nanopore Arrays and Their Use as Templates for Molecular Beam Epitaxy Growth of InGaAs Quantum Wires and Dots (2002)

Hirano, Tetsuro, Ito, Akira, Sato, Taketomo, Ishikawa, Fumitaro, Hasegawa, Hideki

Attempts were made to optimize the parameters of the electrochemical process to form uniform nanopore arrays and utilize them as templates for molecular beam epitaxy (MBE) growth of InP-based quantum...

Prostaglandin F2{alpha}, cytokines and cyclic mechanical stretch augment matrix metalloproteinase-1 secretion from cultured human uterine cervical fibroblast cells (2002)

Yoshida, Masahiro, Sagawa, Norimasa, Itoh, Hiroaki, Yura, Shigeo, Takemura, Maki, Wada, Yukihisa, ...

Human uterine cervical tissue is composed mainly of fibroblast cells and the extracellular matrix in which collagen types I and III predominate. It is hypothesized that these collagens are degraded...

Light Microscopic Observations of Infraciliature and Morphogenesis in Six Species of Rumen Ostracodinium Ciliates (2001)

AKIRA ITO, YUTAKA MIYAZAKI, SOICHI IMAI

Infraciliature and morphogenesis of six rumen ciliates, Ostracodinium mammosum, O. munham, O. dilobum, O. rugoloricatum, O. iwawoi, and O. tiete are described from pyridinated silver...

Nitric oxide increases matrix metalloproteinase-1 production in human uterine cervical fibroblast cells (2001)

Yoshida, Masahiro, Sagawa, Norimasa, Itoh, Hiroaki, Yura, Shigeo, Korita, Daizo, Kakui, Kazuyo, ...

Since uterine cervical ripening is an active biochemical process similar in part to an inflammatory reaction, nitric oxide (NO) has been proposed as a key mediator of this event. However, the...

Modeling of voltage-dependent diffused resistors (1997)

Akira Ito

Abstract — A voltage-dependent diffused resistor model has been developed using conventional voltage controlled current sources (VCCS’s) defined by a two-dimensional polynomial for simulations of...

Context-Sensitive Word Distance by Adaptive Scaling of a Semantic Space (1997)

Hideki Kozima, Akira Ito

This paper proposes a computationally feasible method for measuring the context-sensitive semantic distance between words. The distance is computed by adaptive scaling of a semantic space. In the...

Context-Sensitive Measurement of Word Distance by Adaptive Scaling of a Semantic Space (1996)

Kozima, Hideki, Ito, Akira

The paper proposes a computationally feasible method for measuring context-sensitive semantic distance between words. The distance is computed by adaptive scaling of a semantic space. In the semantic...

The role of fibroblast growth factor-2 in the vascular effects of interleukin-1{beta} in porcine coronary arteries in vivo (1996)

Ito, Akira, Shimokawa, Hiroaki, Fukumoto, Yoshihiro, Kadokami, Toshiaki, Nakaike, Ryuichi, Takayanagi, Tsuneo, ...

Objective We recently demonstrated that chronic treatment with interleukin-1β (IL-1β), a major inflammatory cytokine found in atherosclerotic lesions, induces coronary arteriosclerotic changes and...

Context-Sensitive Measurement of Word Distance by Adaptive Scaling of a Semantic Space (1995)

Hideki Kozima, Akira Ito

The paper proposes a computationally feasible method for measuring contextsensitive semantic distance between words. The distance is computed by adaptive scaling of a semantic space. In the semantic...

Calmodulin Antagonists Differentiate between Ni2+- and Mn2+-Stimulated Phosphatase Activity of Calcineurin (1991)

Mukai, Hideyuki, Ito, Akira, Kishima, Koji, Kuno, Takayoshi, Tanaka, Chikako

The interaction of calmodulin antagonists with a phosphoprotein phosphatase, calcineurin, was investigated using para-nitrophenyl phosphate (pNPP) as a substrate. Calmidazolium, a potent calmodulin...

Incorporation of Cytoplasmic Structures by Developing Proplastids in Dark-Grown Euglena gracilis Cells Transferred to an Inorganic Medium in Darkness (1990)

Osafune, Tetsuaki, Ehara, Tomoko, Ito, Akira, Hase, Eiji

During an early phase of the development of proplastids in dark-grown cells of Euglena gracilis Z caused by the transfer to an inorganic medium in darkness, incorporation of cytoplasmic dense...

Partial Purification and Characterization of Gelatinase and Metal Dependent Peptidase from Rabbit Uterus and Their Synergistic Action on Gelatin In Vitro (1983)

SAKYO, Katsufumi, KOBAYASHI, Jun-ichi, ITO, Akira, MORI, Yo

Two metal dependent proteases were investigated in rabbit uterus using a synthetic substrate, 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-GIy-Gln-D-Arg (Dnp-peptide). One was extracted by homogenization in...

Small signal analysis of MOS capacitor behavior in the depletion and weak inversion modes. (1980)

Ito, Akira.

SPEC. COLL. HAS ARCHIVAL COPY; MICRO. ROOM HAS CIRCULATING MICROFICHE COPY (1 SHEET).

The Existing Forms of Collagenase in the Human Uterine Cervix (1980)

KITAMURA, Kenji, ITO, Akira, MORI, Yo

The existing forms of collagenase [EC 3.4.24.7] in the human uterine cervix were examined. The latent collagenase extracted by homogenization in 0.25% Triton X-100 containing 0.01 M CaCl2 was...

FUNCTIONS OF CALCIUM IN THE CELL WALL OF RICE LEAVES (1967)

ITO, AKIRA, FUJIWARA, AKIO

Rice plants were grown in nutrient solutions containing 0.5, 20, and 500 ppm of calcium as CaO. Microscopic observation revealed that the mesophyll structure in the leaves was disordered at the...

Molecular Characterization and Diagnostic Value of Taenia solium Low-Molecular-Weight Antigen Genes

Sako, Yasuhito, Nakao, Minoru, Ikejima, Takashi, Piao, Xian Zhi, Nakaya, Kazuhiro, Ito, Akira

Neurocysticercosis (NCC) caused by infection with the larvae of Taenia solium is an important cause of neurological disease worldwide. In order to establish an enzyme-linked immunosorbent assay...

Immunoglobulin G (IgG) Subclass and IgE Responses in Human Paragonimiases Caused by Three Different Species

Kong, Yoon, Ito, Akira, Yang, Hyun-Jong, Chung, Young-Bae, Kasuya, Shiro, Kobayashi, Masashi, ...

In 40 cases of human paragonimiases caused by Paragonimus westermani (20 cases), P. miyazakii (10 cases), and P. skrjabini (10 cases), responses of serum immunoglobulin G (IgG), IgG subclasses, and...

Epidemiological Study of a Food-Borne Outbreak of Enterotoxigenic Escherichia coli O25:NM by Pulsed-Field Gel Electrophoresis and Randomly Amplified Polymorphic DNA Analysis

Mitsuda, Toshihiro, Muto, Tetsunori, Yamada, Mikiko, Kobayashi, Nobuyoshi, Toba, Masanori, Aihara, Yukoh, ...

This study investigated the applicability of molecular epidemiological techniques to the identification of the causal agent of an outbreak of diarrhea caused by ingestion of food contaminated with...

Usefulness of Hydatid Cyst Fluid of Echinococcus granulosus Developed in Mice with Secondary Infection for Serodiagnosis of Cystic Echinococcosis in Humans

Mamuti, Wulamu, Yamasaki, Hiroshi, Sako, Yasuhito, Nakaya, Kazuhiro, Nakao, Minoru, Lightowlers, Marshall W., ...

The aim of this work was to assess the usefulness of hydatid cyst fluid (HCF) of Echinococcus granulosus, obtained from mice experimentally infected with hydatid cyst tissue homogenates, for the...

Alveolar Echinococcosis: Characterization of Diagnostic Antigen Em18 and Serological Evaluation of Recombinant Em18

Sako, Yasuhito, Nakao, Minoru, Nakaya, Kazuhiro, Yamasaki, Hiroshi, Gottstein, Bruno, Lightowers, Marshall W., ...

The Echinococcus multilocularis protein Em18 is one of the most promising antigens for use in serodiagnosis of alveolar echinococcosis in human patients. Here we identify an antigenic relationship...

DNA Differential Diagnosis of Human Taeniid Cestodes by Base Excision Sequence Scanning Thymine-Base Reader Analysis with Mitochondrial Genes

Yamasaki, Hiroshi, Nakao, Minoru, Sako, Yasuhito, Nakaya, Kazuhiro, Sato, Marcello Otake, Mamuti, Wulamu, ...

For DNA differential diagnosis of human Taenia cestodes, a base excision sequence scanning thymine-base method using the cytochrome c oxidase subunit I and cytochrome b genes as targets was used. The...

Evaluation of an Enzyme-Linked Immunosorbent Assay (ELISA) with Affinity-Purified Em18 and an ELISA with Recombinant Em18 for Differential Diagnosis of Alveolar Echinococcosis: Results of a Blind Test

Ito, Akira, Xiao, Ning, Liance, Martine, Sato, Marcello O., Sako, Yasuhito, Mamuti, Wulamu, ...

Alveolar echinococcosis (AE) is the most potentially lethal parasitic zoonosis of the nontropical areas in the northern hemisphere, where cystic echinococcosis (CE) is also endemic. Both AE and CE...

Evaluation of Use of Recombinant Em18 and Affinity-Purified Em18 for Serological Differentiation of Alveolar Echinococcosis from Cystic Echinococcosis and Other Parasitic Infections

Xiao, Ning, Mamuti, Wulamu, Yamasaki, Hiroshi, Sako, Yasuhito, Nakao, Minoru, Nakaya, Kazuhiro, ...

To further evaluate recombinant Em18 antigen (rEm18) for immunodiagnosis of human alveolar echinococcosis, 208 serum samples were examined by enzyme-linked immunosorbent assay (ELISA). To...

Comparative Activities of AM-715 and Pipemidic and Nalidixic Acids Against Experimentally Induced Systemic and Urinary Tract Infections

Hirai, Keiji, Ito, Akira, Abe, Yashuo, Suzue, Seigo, Irikura, Tsutomu, Inoue, Matsuhisa, ...

Dose for dose, AM-715 was at least five times as active as pipemidic acid and nalidixic acid against systemic and urinary bladder-kidney infections in mice.

In Vitro Antibacterial Activity of AM-715, a New Nalidixic Acid Analog

Ito, Akira, Hirai, Keiji, Inoue, Matsuhisa, Koga, Hiroshi, Suzue, Seigo, Irikura, Tsutomu, ...

AM-715 [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid] is a new nalidixic acid analog. AM-715 has a broad spectrum of antibacterial activity against gram-positive...

DNA Differential Diagnosis of Taeniasis and Cysticercosis by Multiplex PCR

Yamasaki, Hiroshi, Allan, James C., Sato, Marcello Otake, Nakao, Minoru, Sako, Yasuhito, Nakaya, Kazuhiro, ...

Multiplex PCR was established for differential diagnosis of taeniasis and cysticercosis, including their causative agents. For identification of the parasites, multiplex PCR with cytochrome c oxidase...

Molecular Cloning, Expression, and Serological Evaluation of an 8-Kilodalton Subunit of Antigen B from Echinococcus multilocularis

Mamuti, Wulamu, Yamasaki, Hiroshi, Sako, Yasuhito, Nakao, Minoru, Xiao, Ning, Nakaya, Kazuhiro, ...

Full-length cDNA and genomic DNA encoding an 8-kDa subunit of antigen B from Echinococcus multilocularis (designated EmAgB8/1) were isolated from an E. multilocularis metacestode cDNA library and a...

Solitary Neurocysticercosis Case Caused by Asian Genotype of Taenia solium Confirmed by Mitochondrial DNA Analysis

Yamasaki, Hiroshi, Matsunaga, Shigeo, Yamamura, Koji, Chang, Chia-Cheng, Kawamura, Shunji, Sako, Yasuhito, ...

A Japanese woman presenting with neurologic symptoms was presumptively diagnosed with neurocysticercosis based on imaging findings. Hooklets in the scolex of the resected lesion were not confirmed...

Partial purification and characterization of a novel neutral proteinase from human uterine cervix

Ito, Akira, Ihara, Hiroko, Mori, Yo

1. Human uterine cervical stroma was found to contain a Ca2+-independent neutral proteinase against casein and N-benzoyl-dl-arginine p-nitroanilide (Bz-dl-Arg-Nan). This enzyme was tightly bound to...

A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings

Nagasaka, Yosuke, Dillner, Karin, Ebise, Hayao, Teramoto, Reiji, Nakagawa, Hiroyuki, Lilius, Lena, ...

Alzheimer's disease (AD) is a neurodegenerative disease with an insidious onset and progressive course that inevitably leads to death. The current diagnostic tools do not allow for diagnosis until...

Molecular Characterization and Diagnostic Value of Taenia solium Low-Molecular-Weight Antigen Genes

Sako, Yasuhito, Nakao, Minoru, Ikejima, Takashi, Piao, Xian Zhi, Nakaya, Kazuhiro, Ito, Akira

Neurocysticercosis (NCC) caused by infection with the larvae of Taenia solium is an important cause of neurological disease worldwide. In order to establish an enzyme-linked immunosorbent assay...

Immunoglobulin G (IgG) Subclass and IgE Responses in Human Paragonimiases Caused by Three Different Species

Kong, Yoon, Ito, Akira, Yang, Hyun-Jong, Chung, Young-Bae, Kasuya, Shiro, Kobayashi, Masashi, ...

In 40 cases of human paragonimiases caused by Paragonimus westermani (20 cases), P. miyazakii (10 cases), and P. skrjabini (10 cases), responses of serum immunoglobulin G (IgG), IgG subclasses, and...

Epidemiological Study of a Food-Borne Outbreak of Enterotoxigenic Escherichia coli O25:NM by Pulsed-Field Gel Electrophoresis and Randomly Amplified Polymorphic DNA Analysis

Mitsuda, Toshihiro, Muto, Tetsunori, Yamada, Mikiko, Kobayashi, Nobuyoshi, Toba, Masanori, Aihara, Yukoh, ...

This study investigated the applicability of molecular epidemiological techniques to the identification of the causal agent of an outbreak of diarrhea caused by ingestion of food contaminated with...

Usefulness of Hydatid Cyst Fluid of Echinococcus granulosus Developed in Mice with Secondary Infection for Serodiagnosis of Cystic Echinococcosis in Humans

Mamuti, Wulamu, Yamasaki, Hiroshi, Sako, Yasuhito, Nakaya, Kazuhiro, Nakao, Minoru, Lightowlers, Marshall W., ...

The aim of this work was to assess the usefulness of hydatid cyst fluid (HCF) of Echinococcus granulosus, obtained from mice experimentally infected with hydatid cyst tissue homogenates, for the...

Alveolar Echinococcosis: Characterization of Diagnostic Antigen Em18 and Serological Evaluation of Recombinant Em18

Sako, Yasuhito, Nakao, Minoru, Nakaya, Kazuhiro, Yamasaki, Hiroshi, Gottstein, Bruno, Lightowers, Marshall W., ...

The Echinococcus multilocularis protein Em18 is one of the most promising antigens for use in serodiagnosis of alveolar echinococcosis in human patients. Here we identify an antigenic relationship...

DNA Differential Diagnosis of Human Taeniid Cestodes by Base Excision Sequence Scanning Thymine-Base Reader Analysis with Mitochondrial Genes

Yamasaki, Hiroshi, Nakao, Minoru, Sako, Yasuhito, Nakaya, Kazuhiro, Sato, Marcello Otake, Mamuti, Wulamu, ...

For DNA differential diagnosis of human Taenia cestodes, a base excision sequence scanning thymine-base method using the cytochrome c oxidase subunit I and cytochrome b genes as targets was used. The...

Evaluation of an Enzyme-Linked Immunosorbent Assay (ELISA) with Affinity-Purified Em18 and an ELISA with Recombinant Em18 for Differential Diagnosis of Alveolar Echinococcosis: Results of a Blind Test

Ito, Akira, Xiao, Ning, Liance, Martine, Sato, Marcello O., Sako, Yasuhito, Mamuti, Wulamu, ...

Alveolar echinococcosis (AE) is the most potentially lethal parasitic zoonosis of the nontropical areas in the northern hemisphere, where cystic echinococcosis (CE) is also endemic. Both AE and CE...

Evaluation of Use of Recombinant Em18 and Affinity-Purified Em18 for Serological Differentiation of Alveolar Echinococcosis from Cystic Echinococcosis and Other Parasitic Infections

Xiao, Ning, Mamuti, Wulamu, Yamasaki, Hiroshi, Sako, Yasuhito, Nakao, Minoru, Nakaya, Kazuhiro, ...

To further evaluate recombinant Em18 antigen (rEm18) for immunodiagnosis of human alveolar echinococcosis, 208 serum samples were examined by enzyme-linked immunosorbent assay (ELISA). To...

Comparative Activities of AM-715 and Pipemidic and Nalidixic Acids Against Experimentally Induced Systemic and Urinary Tract Infections

Hirai, Keiji, Ito, Akira, Abe, Yashuo, Suzue, Seigo, Irikura, Tsutomu, Inoue, Matsuhisa, ...

Dose for dose, AM-715 was at least five times as active as pipemidic acid and nalidixic acid against systemic and urinary bladder-kidney infections in mice.

In Vitro Antibacterial Activity of AM-715, a New Nalidixic Acid Analog

Ito, Akira, Hirai, Keiji, Inoue, Matsuhisa, Koga, Hiroshi, Suzue, Seigo, Irikura, Tsutomu, ...

AM-715 [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid] is a new nalidixic acid analog. AM-715 has a broad spectrum of antibacterial activity against gram-positive...

DNA Differential Diagnosis of Taeniasis and Cysticercosis by Multiplex PCR

Yamasaki, Hiroshi, Allan, James C., Sato, Marcello Otake, Nakao, Minoru, Sako, Yasuhito, Nakaya, Kazuhiro, ...

Multiplex PCR was established for differential diagnosis of taeniasis and cysticercosis, including their causative agents. For identification of the parasites, multiplex PCR with cytochrome c oxidase...

Molecular Cloning, Expression, and Serological Evaluation of an 8-Kilodalton Subunit of Antigen B from Echinococcus multilocularis

Mamuti, Wulamu, Yamasaki, Hiroshi, Sako, Yasuhito, Nakao, Minoru, Xiao, Ning, Nakaya, Kazuhiro, ...

Full-length cDNA and genomic DNA encoding an 8-kDa subunit of antigen B from Echinococcus multilocularis (designated EmAgB8/1) were isolated from an E. multilocularis metacestode cDNA library and a...

Solitary Neurocysticercosis Case Caused by Asian Genotype of Taenia solium Confirmed by Mitochondrial DNA Analysis

Yamasaki, Hiroshi, Matsunaga, Shigeo, Yamamura, Koji, Chang, Chia-Cheng, Kawamura, Shunji, Sako, Yasuhito, ...

A Japanese woman presenting with neurologic symptoms was presumptively diagnosed with neurocysticercosis based on imaging findings. Hooklets in the scolex of the resected lesion were not confirmed...

Partial purification and characterization of a novel neutral proteinase from human uterine cervix

Ito, Akira, Ihara, Hiroko, Mori, Yo

1. Human uterine cervical stroma was found to contain a Ca2+-independent neutral proteinase against casein and N-benzoyl-dl-arginine p-nitroanilide (Bz-dl-Arg-Nan). This enzyme was tightly bound to...

A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings

Nagasaka, Yosuke, Dillner, Karin, Ebise, Hayao, Teramoto, Reiji, Nakagawa, Hiroyuki, Lilius, Lena, ...

Alzheimer's disease (AD) is a neurodegenerative disease with an insidious onset and progressive course that inevitably leads to death. The current diagnostic tools do not allow for diagnosis until...

Correction of Experimentally Induced High Myopia Inhibits Recovery by Spectacle Lenses in Chicks

Ito, Akira, Kawabata, Hidehito, Adachi-Usami, Emiko, 伊藤, 彰, イトウ, アキラ, 川端, 秀仁, ...

Purpose: Whether the recovery from experimentally induced high myopia is a vision-dependent process was studied in chicks.Methods: Initially forty chicks were monocularly form-deprived from day 1...

Correction of Experimentally Induced High Myopia Inhibits Recovery by Spectacle Lenses in Chicks

Ito, Akira, Kawabata, Hidehito, Adachi-Usami, Emiko, 伊藤, 彰, イトウ, アキラ, 川端, 秀仁, ...

Purpose: Whether the recovery from experimentally induced high myopia is a vision-dependent process was studied in chicks.Methods: Initially forty chicks were monocularly form-deprived from day 1...

An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2–mediated Bone Resorption Associated with Inflammation

Miyaura, Chisato, Inada, Masaki, Matsumoto, Chiho, Ohshiba, Tomoyasu, Uozumi, Naonori, Shimizu, Takao, ...

Prostaglandin E (PGE)2 produced by osteoblasts acts as a potent stimulator of bone resorption. Inflammatory bone loss is accompanied by osteoclast formation induced by bone-resorbing cytokines, but...

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Hansson Petersen, Camilla A., Alikhani, Nyosha, Behbahani, Homira, Wiehager, Birgitta, Pavlov, Pavel F., Alafuzoff, Irina, ...

The amyloid β-peptide (Aβ) has been suggested to exert its toxicity intracellularly. Mitochondrial functions can be negatively affected by Aβ and accumulation of Aβ has been detected in...

Community surveys and risk factor analysis of human alveolar and cystic echinococcosis in Ningxia Hui Autonomous Region, China.

Yang, Yu Rong, Sun, Tao, Li, Zhengzhi, Zhang, Jianzhong, Teng, Jing, Liu, Xongzhou, ...

OBJECTIVE: To determine the true community prevalence of human cystic (CE) and alveolar (AE) echinococcosis (hydatid disease) in a highly endemic region in Ningxia Hui, China, by detecting...

Loop-Mediated Isothermal Amplification Method for Differentiation and Rapid Detection of Taenia Species▿

Nkouawa, Agathe, Sako, Yasuhito, Nakao, Minoru, Nakaya, Kazuhiro, Ito, Akira

Rapid detection and differentiation of Taenia species are required for the control and prevention of taeniasis and cysticercosis in areas where these diseases are endemic. Because of the lower...

Development of an Immunochromatographic Test To Detect Antibodies against Recombinant Em18 for Diagnosis of Alveolar Echinococcosis▿

Sako, Yasuhito, Fukuda, Kenta, Kobayashi, Yukuharu, Ito, Akira

An immunochromatographic test (ICT) for the rapid detection of antibodies to Echinococcus multilocularis was developed. The ICT showed a sensitivity of 94% and a specificity of 95.4%. High degrees of...

Natural Infection of the Ground Squirrel (Spermophilus spp.) with Echinococcus granulosus in China

Yang, Yu Rong, Liu, Tianxi, Bai, Xueli, Boufana, Belgees, Craig, Philip S., Nakao, Minoru, ...

Echinococcus granulosus and E. multilocularis are important zoonotic pathogens that cause serious disease in humans. E. granulosus can be transmitted through sylvatic cycles, involving wild...

Growth Inhibition of Re-Challenge B16 Melanoma Transplant by Conjugates of Melanogenesis Substrate and Magnetite Nanoparticles as the Basis for Developing Melanoma-Targeted Chemo-Thermo-Immunotherapy

Takada, Tomoaki, Yamashita, Toshiharu, Sato, Makito, Sato, Akiko, Ono, Ichiro, Tamura, Yasuaki, ...

Melanogenesis substrate, N-propionyl-cysteaminylphenol (NPrCAP), is selectively incorporated into melanoma cells and inhibits their growth by producing cytotoxic free radicals. Magnetite...