Akira Nishizono

Serological Assessment of the Early Response to Eradication Therapy Using an Immunodominant Outer Membrane Protein of Helicobacter pylori

Nishizono, Akira, Gotoh, Takayuki, Fujioka, Toshio, Murakami, Kazunari, Kubota, Toshihiro, Nasu, Masaru, ...

Eradication of Helicobacter pylori infection cures gastritis and prevents recurrence of peptic ulcers. Endoscopy is usually used to evaluate the effectiveness of eradication therapy. We designed a...

Comparison of Genomic Structures and Antigenic Reactivities of Orthologous 29-Kilodalton Outer Membrane Proteins of Helicobacter pylori

Sumie, Akihiro, Yamashiro, Tetsu, Nakashima, Kazutoshi, Nasu, Masaru, Watanabe, Makoto, Nishizono, Akira

We purified a 29-kDa Helicobacter pylori outer membrane protein (Omp29 protein) and cloned the gene encoding the protein from H. pylori strain ATCC 43504. The Omp29 gene corresponded to the reported...

Diversity in Protein Synthesis and Viability of Helicobacter pylori Coccoid Forms in Response to Various Stimuli

Mizoguchi, Hiromoto, Fujioka, Toshio, Kishi, Kenji, Nishizono, Akira, Kodama, Reiji, Nasu, Masaru

The viability of the coccoid forms of Helicobacter pylori was evaluated by assessing protein synthesis. Metabolic labeling studies showed the synthesis of proteins and the specific protein profiles...

Local Secretory Immunoglobulin A and Postimmunization Gastritis Correlate with Protection against Helicobacter pylori Infection after Oral Vaccination of Mice

Goto, Takayuki, Nishizono, Akira, Fujioka, Toshio, Ikewaki, Junko, Mifune, Kumato, Nasu, Masaru

C57BL/6 mice were orally immunized with five weekly doses of 2 mg, 200 μg, or 2 μg of Helicobacter pylori (Sydney strain) whole-cell sonicate combined with cholera toxin. One week after the last...

Antiviral Effects of Geranylgeranylacetone: Enhancement of MxA Expression and Phosphorylation of PKR during Influenza Virus Infection

Unoshima, Masako, Iwasaka, Hideo, Eto, Junko, Takita-Sonoda, Yoshiko, Noguchi, Takayuki, Nishizono, Akira

A cyclic polyisoprenoid compound, geranylgeranylacetone (GGA), has been used as antiulcer drug. GGA is also a potent inducer of heat shock proteins (HSPs). HSPs are considered to induce an antiviral...

Transfer of Antigen-Pulsed Dendritic Cells Induces Specific T-Cell Proliferation and a Therapeutic Effect against Long-Term Helicobacter pylori Infection in Mice

Otsu, Satoshi, Gotoh, Kazuyo, Yamashiro, Tetsu, Yamagata, Junpei, Shin, Kouichirou, Fujioka, Toshio, ...

Helicobacter pylori causes persistent infection of the stomach and results in chronic gastritis and peptic ulcers. Jaws II cells, derived from mouse bone marrow, were pulsed with live or...

Serological Assessment of the Early Response to Eradication Therapy Using an Immunodominant Outer Membrane Protein of Helicobacter pylori

Nishizono, Akira, Gotoh, Takayuki, Fujioka, Toshio, Murakami, Kazunari, Kubota, Toshihiro, Nasu, Masaru, ...

Eradication of Helicobacter pylori infection cures gastritis and prevents recurrence of peptic ulcers. Endoscopy is usually used to evaluate the effectiveness of eradication therapy. We designed a...

Comparison of Genomic Structures and Antigenic Reactivities of Orthologous 29-Kilodalton Outer Membrane Proteins of Helicobacter pylori

Sumie, Akihiro, Yamashiro, Tetsu, Nakashima, Kazutoshi, Nasu, Masaru, Watanabe, Makoto, Nishizono, Akira

We purified a 29-kDa Helicobacter pylori outer membrane protein (Omp29 protein) and cloned the gene encoding the protein from H. pylori strain ATCC 43504. The Omp29 gene corresponded to the reported...

Diversity in Protein Synthesis and Viability of Helicobacter pylori Coccoid Forms in Response to Various Stimuli

Mizoguchi, Hiromoto, Fujioka, Toshio, Kishi, Kenji, Nishizono, Akira, Kodama, Reiji, Nasu, Masaru

The viability of the coccoid forms of Helicobacter pylori was evaluated by assessing protein synthesis. Metabolic labeling studies showed the synthesis of proteins and the specific protein profiles...

Local Secretory Immunoglobulin A and Postimmunization Gastritis Correlate with Protection against Helicobacter pylori Infection after Oral Vaccination of Mice

Goto, Takayuki, Nishizono, Akira, Fujioka, Toshio, Ikewaki, Junko, Mifune, Kumato, Nasu, Masaru

C57BL/6 mice were orally immunized with five weekly doses of 2 mg, 200 μg, or 2 μg of Helicobacter pylori (Sydney strain) whole-cell sonicate combined with cholera toxin. One week after the last...

Antiviral Effects of Geranylgeranylacetone: Enhancement of MxA Expression and Phosphorylation of PKR during Influenza Virus Infection

Unoshima, Masako, Iwasaka, Hideo, Eto, Junko, Takita-Sonoda, Yoshiko, Noguchi, Takayuki, Nishizono, Akira

A cyclic polyisoprenoid compound, geranylgeranylacetone (GGA), has been used as antiulcer drug. GGA is also a potent inducer of heat shock proteins (HSPs). HSPs are considered to induce an antiviral...

Transfer of Antigen-Pulsed Dendritic Cells Induces Specific T-Cell Proliferation and a Therapeutic Effect against Long-Term Helicobacter pylori Infection in Mice

Otsu, Satoshi, Gotoh, Kazuyo, Yamashiro, Tetsu, Yamagata, Junpei, Shin, Kouichirou, Fujioka, Toshio, ...

Helicobacter pylori causes persistent infection of the stomach and results in chronic gastritis and peptic ulcers. Jaws II cells, derived from mouse bone marrow, were pulsed with live or...

Identification of the Major Antigenic Protein of Helicobacter cinaedi and Its Immunogenicity in Humans with H. cinaedi Infections▿

Iwashita, Hirofumi, Fujii, Shigemoto, Kawamura, Yoshiaki, Okamoto, Tatsuya, Sawa, Tomohiro, Masaki, Takayuki, ...

Helicobacter cinaedi infection is now recognized as an increasingly important emerging disease. Its pathogenesis and epidemiological features are not fully understood, however. Here, we investigated...