Ahern, Jennifer, Hubbard, Alan, Galea, Sandro
Peer Reviewed
Ahern, Jennifer, Galea, Sandro, Hubbard, Alan, Syme, S. Leonard
Peer Reviewed
Ahern, Jennifer, Hubbard, Alan, Galea, Sandro
Causal inference methods allow estimation of the effects of potential public health interventions on the population burden of disease. Motivated by calls for epidemiologic research to be presented in...
Polymorphisms In The, Christine F. Skibola, Martyn T. Smith, Alan Hubbard, Barry Shane, Abby C. Roberts, ...
this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 U.S.C. section...
Flow Cytometric Detection of Intracellular Th1/Th2 Cytokines (2008)
Using Whole Blood, Paurene Duramad, Christopher W. Mcmahon, Alan Hubbard, Brenda Eskenazi, Nina T. Holl
Few biological markers of immune function have been thoroughly validated for use in epidemiologic studies that involve delayed sample processing and analysis. Here, we report our validation results...
Polymorphisms And Haplotypes, Christine F. Skibola, Matthew S. Forrest, Luz Agana, Alan Hubbard, Martyn T. Smith, ...
this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 U.S.C. section...
Body Mass Index, Leptin and Leptin Receptor (2008)
Polymorphisms And Non-Hodgkin, Christine F. Skibola, Elizabeth A. Holly, Matthew S. Forrest, Alan Hubbard, Paige M. Bracci, ...
In a population-based case-control study, obesity was associated with elevated odds ratios (ORs) for non-Hodgkin lymphoma (NHL), and the two major subtypes, diffuse large cell (DLCL) and follicular...
Ecologic vulnerabilities and capacities related to population health: a test of a model (2008)
Ahern, Jennifer, Galea, Sandro, Hubbard, Alan, Karpati, Adam
Peer Reviewed
“Culture of drinking” and individual problems with alcohol use (2008)
Ahern, Jennifer, Galea, Sandro, Hubbard, Alan, Midanik, Laura, Syme, Leonard S
Peer Reviewed
"Culture of Drinking" and Individual Problems with Alcohol Use (2008)
Ahern, Jennifer, Galea, Sandro, Hubbard, Alan, Midanik, Lorraine, Syme, S. Leonard
Binge drinking is a substantial and growing health problem. Community norms about drinking and drunkenness may influence individual drinking problems. Using data from the New York Social Environment...
The longitudinal determinants of post-traumatic stress in a population-based cohort study (2007)
Galea, Sandro, Ahern, Jennifer, Hubbard, Alan, Cerda, Magdalena, Goldmann, Emily, Vlahov, David
Peer Reviewed
Aging Impacts Transcriptome but not Genome of Hormone-dependent Breast Cancers (2007)
Yau, Christina, Fedele, Vita, Roydasgupta, Ritu, Fridlyand, Jane, Hubbard, Alan, Gray, Joe W., ...
Bates, Sarah J., Trostle, James, Cevallos, William T., Hubbard, Alan, Eisenberg, Joseph N. S.
Social networks and geographic structures of communities are important predictors of infectious disease transmission. To examine their joint effects on diarrheal disease and how these effects might...
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers (2007)
Yau, Christina, Fedele, Vita, Roydasgupta, Ritu, Fridlyand, Jane, Hubbard, Alan, Gray, Joe W, ...
Abstract Introduction Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age at diagnosis has been shown to be an independent indicator of...
Pai, Madhukar, Flores, Laura L, Hubbard, Alan, Riley, Lee W, Colford, John M
Abstract Background Conventional tests for tuberculous pleuritis have several limitations. A variety of new, rapid tests such as nucleic acid amplification tests – including polymerase chain...
Zhao and Tsiatis (1997) consider the problem of estimation of the distribution of the quality adjusted lifetime when the chronological survival time is subject to right-censoring. The quality...
Zhao and Tsiatis (1997) consider the problem of estimation of the distribution of the quality adjusted lifetime U when the chronological survival time T is subject to rightcensoring. The quality...
Spear, Robert C, Hubbard, Alan, Liang, Song, Seto, Edmund
Mathematical models of disease transmission processes can serve as platforms for integration of diverse data, including site-specific information, for the purpose of designing strategies for...
Fenster, Laura, Eskenazi, Brenda, Anderson, Meredith, Bradman, Asa, Harley, Kim, Hernandez, Hedy, ...
From 1940 through the 1970s, organochlorine compounds were widely used as insecticides in the United States. Thereafter, their use was severely restricted after recognition of their persistence in...
Eisenberg, Joseph N.S., Hubbard, Alan, Wade, Timothy J., Sylvester, Matthew D., LeChevallier, Mark W., Levy, Deborah A., ...
Risk assessments and intervention trials have been used by the U.S. Environmental Protection Agency to estimate drinking water health risks. Seldom are both methods used concurrently. Between 2001...
Spear, Robert C, Hubbard, Alan, Liang, Song, Seto, Edmund
Mathematical models of disease transmission processes can serve as platforms for integration of diverse data, including site-specific information, for the purpose of designing strategies for...
Fenster, Laura, Eskenazi, Brenda, Anderson, Meredith, Bradman, Asa, Harley, Kim, Hernandez, Hedy, ...
From 1940 through the 1970s, organochlorine compounds were widely used as insecticides in the United States. Thereafter, their use was severely restricted after recognition of their persistence in...
Eisenberg, Joseph N.S., Hubbard, Alan, Wade, Timothy J., Sylvester, Matthew D., LeChevallier, Mark W., Levy, Deborah A., ...
Risk assessments and intervention trials have been used by the U.S. Environmental Protection Agency to estimate drinking water health risks. Seldom are both methods used concurrently. Between 2001...
Resistance Exercise Reverses Aging in Human Skeletal Muscle
Melov, Simon, Tarnopolsky, Mark A., Beckman, Kenneth, Felkey, Krysta, Hubbard, Alan
Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia....
Eisenberg, Joseph N. S., Cevallos, William, Ponce, Karina, Levy, Karen, Bates, Sarah J., Scott, James C., ...
Environmental change plays a large role in the emergence of infectious disease. The construction of a new road in a previously roadless area of northern coastal Ecuador provides a valuable natural...
Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
Melov, Simon, Adlard, Paul A., Morten, Karl, Johnson, Felicity, Golden, Tamara R., Hinerfeld, Doug, ...
Age-related neurodegenerative disease has been mechanistically linked with mitochondrial dysfunction via damage from reactive oxygen species produced within the cell. We determined whether increased...
Liang, Song, Seto, Edmund Y. W., Remais, Justin V., Zhong, Bo, Yang, Changhong, Hubbard, Alan, ...
Environmental effects on the transmission of many parasitic diseases are well recognized, but the role of specific factors like climate and agricultural practices in modulating transmission is seldom...
Golden, Tamara R, Beckman, Kenneth B, Lee, Andreia H J, Dudek, Nancy, Hubbard, Alan, Samper, Enrique, ...
The nematode Caenorhabditis elegans has become one of the most widely used model systems for the study of aging, yet very little is known about how C. elegans age. The development of the worm, from...
Greenhouse, Bryan, Dokomajilar, Christian, Hubbard, Alan, Rosenthal, Philip J., Dorsey, Grant
Antimalarial clinical trials use genotyping techniques to distinguish new infection from recrudescence. In areas of high transmission, the accuracy of genotyping may be compromised due to the high...
Aging impacts transcriptomes but not genomes of hormone-dependent breast cancers
Yau, Christina, Fedele, Vita, Roydasgupta, Ritu, Fridlyand, Jane, Hubbard, Alan, Gray, Joe W, ...
Estimation of treatment effects in randomized trials with non-compliance and a dichotomous outcome
Alan Hubbard, Nicholas P. Jewell
We propose a class of estimators of the treatment effect on a dichotomous outcome among the treated subjects within covariate and treatment arm strata in randomized trials with non-compliance. Recent...
Estimation of Treatment Effects in Randomized Trials with Noncompliance and a Dichotomous Outcome
We propose a class of estimators of a received treatment effect on a dichotomous outcome among the treated subjects within covariate and treatment arm strata in randomized trials with non-compliance....
A Comparison of Methods to Control Type I Errors in Microarray Studies
Jinsong Chen, Martyn Smith, Alan Hubbard
Microarray studies often need to simultaneously examine thousands of genes to determine which are differentially expressed. One main challenge in those studies is to find suitable multiple testing...
When trying to learn a model for the prediction of an outcome given a set of covariates, a statistician has many estimation procedures in their toolbox. A few examples of these candidate learners...
Quantile-Function Based Null Distribution in Resampling Based Multiple Testing
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a sample of independent and identically distributed observations is a fundamental and important...
Issues of Processing and Multiple Testing of SELDI-TOF MS Proteomic Data
Merrill Birkner, Alan Hubbard, Christine Skibola, Christine Hegedus, Martyn Smith
A new data filtering method for SELDI-TOF MS proteomic spectra data is described. We examined technical repeats (2 per subject) of intensity versus m/z (mass/charge) of bone marrow cell lysate for...
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a sample of independent and identically distributed observations is a fundamental and important...
Skibola, Christine F., Bracci, Paige M., Halperin, Eran, Nieters, Alexandra, Hubbard, Alan, Paynter, Randi A., ...
Following the Water: A Controlled Study of Drinking Water Storage in Northern Coastal Ecuador
Levy, Karen, Nelson, Kara L., Hubbard, Alan, Eisenberg, Joseph N.S.
Bell, Russell, Hubbard, Alan, Chettier, Rakesh, Chen, Di, Miller, John P., Kapahi, Pankaj, ...
We have mapped a protein interaction network of human homologs of proteins that modify longevity in invertebrate species. This network is derived from a proteome-scale human protein interaction Core...
A functional TNFRSF5 gene variant is associated with risk of lymphoma
Skibola, Christine F., Nieters, Alexandra, Bracci, Paige M., Curry, John D., Agana, Luz, Skibola, Danica R., ...
CD40 and its ligand, CD154, are major costimulatory molecules whose interactions are important in humoral and cellular immunity. We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5...
Abadi, Arkan, Glover, Elisa I., Isfort, Robert J., Raha, Sandeep, Safdar, Adeel, Yasuda, Nobuo, ...
Advancements in animal models and cell culture techniques have been invaluable in the elucidation of the molecular mechanisms that regulate muscle atrophy. However, few studies have examined muscle...
Quantile-Function Based Null Distribution in Resampling Based Multiple Testing
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a sample of independent and identically distributed observations is a fundamental and important...
Issues of Processing and Multiple Testing of SELDI-TOF MS Proteomic Data
Merrill Birkner, Alan Hubbard, Christine Skibola, Christine Hegedus, Martyn Smith
A new data filtering method for SELDI-TOF MS proteomic spectra data is described. We examined technical repeats (2 per subject) of intensity versus m/z (mass/charge) of bone marrow cell lysate for...
When trying to learn a model for the prediction of an outcome given a set of covariates, a statistician has many estimation procedures in their toolbox. A few examples of these candidate learners...
A Comparison of Methods to Control Type I Errors in Microarray Studies
Jinsong Chen, Martyn Smith, Alan Hubbard
Microarray studies often need to simultaneously examine thousands of genes to determine which are differentially expressed. One main challenge in those studies is to find suitable multiple testing...
Simultaneously testing a collection of null hypotheses about a data generating distribution based on a sample of independent and identically distributed observations is a fundamental and important...