Alan L. Schmaljohn

Multiagent Vaccines Vectored by Venezuelan Equine Encephalitis Virus Replicon Elicits Immune Responses to Marburg Virus and Protection Against Anthrax and Botulinum Neurotoxin in Mice (2007)

Lee, John S., Groebner, Jennifer L., Hadjipanayis, Angela G., Negley, Diane L., Schmaljohn, Alan L., Welkos, Susan L., ...

The development of multiagent vaccines offers the advantage of eliciting protection against multiple diseases with minimal inoculations over a shorter time span. We report here the results of using...

Hantaan Virus M RNA: Coding Strategy, Nucleotide Sequence, and Gene Order, (1998)

Schmaljohn,Connie S., Schmaljohn,Alan L., Dalrymple,Joel M.

The M genome segment of Hantaan virus was molecularly cloned and the nucleotide sequence of cDNA was determined. The virion RNA is 3616 bases long with 3'-and 5'-terminal nucleotide sequences...

Baculovirus Expression of the Small Genome Segment of Hantaan Virus and Potential Use of the Expressed Nucleocapsid Protein as a Diagnostic Antigen, (1998)

Schmaljohn, Connie S., Sugiyama, Kazuyoshi, Schmaljohn, Alan L., Bishop, David H.

Autographa californica nuclear polyhedrosis virus (AcNPV) was used as an expression vector for the nucleocapsid protein gene of Hantaan virus. Two different cDNA clones representing the small genome...

The Evolving Field of Biodefence: Therapeutic Developments and Diagnostics (1998)

Burnett, James C., Henchal, Erik A., Schmaljohn, Alan L., Bavari, Sina

The threat of bioterrorism and the potential use of biological weapons against both military and civilian populations have become major concerns for governments around the world. For perspective, in...

De Novo Synthesis of Marburg Virus Antigens from Adenovirus Vectors Induce Potent Humoral and Cellular Immune Responses (1998)

Wang, Danher, Schmaljohn, Alan L., Raja, Nicholas U., Trubey, Charles M., Juompan, Laure Y., Luo, Min, ...

Marburg virus (MARV) is an African filovirus that causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, there are no MARV vaccines or therapies approved for human use. We...

Activation of Triggering Receptor Expressed on Myeloid Cells-1 on Human Neutrophils by Marburg and Ebola Viruses (1998)

Mohamadzadeh, Mansour, Coberley, Sadie S., Olinger, Gene G., Kalina, Warren V., Ruthel, Gordon, Fullter, Claudette L., ...

Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate...

Togavirus-Specific Immune Effector Mechanisms. (1998)

Cole, Gerald A., Schmaljohn, Alan L.

Interactions between alphaviruses, antibodies, and cells were examined as part of an overall effort to characterize relevant antigens and immune effector mechanisms. Antibody-dependent...

Real-Time PCR Assay To Detect Smallpox Virus

Sofi Ibrahim, M., Kulesh, David A., Saleh, Sharron S., Damon, Inger K., Esposito, Joseph J., Schmaljohn, Alan L., ...

We developed a highly sensitive and specific assay for the rapid detection of smallpox virus DNA on both the Smart Cycler and LightCycler platforms. The assay is based on TaqMan chemistry with the...

Activation of Triggering Receptor Expressed on Myeloid Cells-1 on Human Neutrophils by Marburg and Ebola Viruses

Mohamadzadeh, Mansour, Coberley, Sadie S., Olinger, Gene G., Kalina, Warren V., Ruthel, Gordon, Fuller, Claudette L., ...

Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate...

Real-Time PCR Assay To Detect Smallpox Virus

Sofi Ibrahim, M., Kulesh, David A., Saleh, Sharron S., Damon, Inger K., Esposito, Joseph J., Schmaljohn, Alan L., ...

We developed a highly sensitive and specific assay for the rapid detection of smallpox virus DNA on both the Smart Cycler and LightCycler platforms. The assay is based on TaqMan chemistry with the...

Activation of Triggering Receptor Expressed on Myeloid Cells-1 on Human Neutrophils by Marburg and Ebola Viruses

Mohamadzadeh, Mansour, Coberley, Sadie S., Olinger, Gene G., Kalina, Warren V., Ruthel, Gordon, Fuller, Claudette L., ...

Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate...