Alan R. Kimmel

Short Title: AMPK And Mitochondrial Disease (2008)

Paul B. Bokko, Lisa Francione, Esther B, Afsar U. Ahmed, Sarah J, Xiuli Huang, ...

AMP-activated protein kinase

A G{alpha}-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement (2004)

Brzostowski, Joseph A., Parent, Carole A., Kimmel, Alan R.

Chemotactic cells, including neutrophils and Dictyostelium discoideum, orient and move directionally in very shallow chemical gradients. As cells polarize, distinct structural and signaling...

A G{alpha}-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement (2004)

Brzostowski, Joseph A., Parent, Carole A., Kimmel, Alan R.

Chemotactic cells, including neutrophils and Dictyostelium discoideum, orient and move directionally in very shallow chemical gradients. As cells polarize, distinct structural and signaling...

dictyBase: a new Dictyostelium discoideum genome database (2004)

Kreppel, Lisa, Fey, Petra, Gaudet, Pascale, Just, Eric, Kibbe, Warren A., Chisholm, Rex L., ...

Dictyostelium discoideum is a powerful and genetically tractable model system used for the study of numerous cellular molecular mechanisms including chemotaxis, phagocytosis and signal transduction....

A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system (2004)

Faix, Jan, Kreppel, Lisa, Shaulsky, Gad, Schleicher, Michael, Kimmel, Alan R.

Dictyostelium discoideum has proven an exceptionally powerful system for studying numerous aspects of cellular and developmental functions. The relatively small (∼34 Mb) chromosomal genome of...

A G{alpha}-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement (2004)

Brzostowski, Joseph A., Parent, Carole A., Kimmel, Alan R.

Chemotactic cells, including neutrophils and Dictyostelium discoideum, orient and move directionally in very shallow chemical gradients. As cells polarize, distinct structural and signaling...

Genomic database resources for Dictyostelium discoideum (2002)

Kreppel, Lisa, Kimmel, Alan R.

Dictyostelium is an attractive model system for the study of mechanisms basic to cellular function or complex multicellular developmental processes. Recent advances in Dictyostelium genomics have...

Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium (1997)

Ginsburg, Gail T., Kimmel, Alan R.

The Cyclic Nucleotide Specificity of Three cAMP Receptors in Dictyostelium (1992)

Johnson, Ronald L., Kimmel, Alan R., Saxe III, Charles L., Jastorff, Bernd, Devreotes, Peter N.

cAMP receptors mediate signal transduction pathways during development in Dictyostelium. A cAMP receptor (cAR1) has been cloned and sequenced and recently several other cAR genes have been...

G Protein Linked Signal Transduction Pathways in Development: Dictyostetium as an Experimental System (1989)

Kimmel, Alan R., Firtel, Richard A., Devreotes, Peter N.

It has been 22 years since cAMP was identified as the acrasin, i.e., the chemotactic substance mediating aggregation in Dictyostelium discoideum. cAMP is also known to control gene expression...

Guide to molecular cloning techniques / edited by Shelby L. Berger, Alan R. Kimmel (1987)

Berger, Shelby L, Kimmel, Alan R

Sequence organization within and flanking clusters of 5S ribosomal RNA genes in Tetrahymena (1984)

Pederson, David S., Yao, Meng-Chao, Kimmel, Alan R., Gorovsky, Martin A.

Macro- and micronuclei of Tetrahymena thermophila each contain approximately 30 clusters of 5S genes per haploid genome. Structural changes in DNA sequences associated with some of these clusters...

Intervening sequences in a Dictyostelium gene that encodes a low abundance class mRNA (1980)

Kimmel, Alan R., Firtel, Richard A.

Using S1 nuclease protection experiments and DNA sequencing, we have identified two intervening sequences (introns) within a Dictyostelium gene that codes for a low abundance class mRNA. The two...

Genomic database resources for Dictyostelium discoideum

Kreppel, Lisa, Kimmel, Alan R.

Dictyostelium is an attractive model system for the study of mechanisms basic to cellular function or complex multicellular developmental processes. Recent advances in Dictyostelium genomics have...

dictyBase: a new Dictyostelium discoideum genome database

Kreppel, Lisa, Fey, Petra, Gaudet, Pascale, Just, Eric, Kibbe, Warren A., Chisholm, Rex L., ...

Dictyostelium discoideum is a powerful and genetically tractable model system used for the study of numerous cellular molecular mechanisms including chemotaxis, phagocytosis and signal transduction....

Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium

Ginsburg, Gail T., Kimmel, Alan R.

Early during Dictyostelium development a fundamental cell-fate decision establishes the anteroposterior (prestalk/prespore) axis. Signaling via the 7-transmembrane cAMP receptor CAR4 is essential for...

A Gα-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement

Brzostowski, Joseph A., Parent, Carole A., Kimmel, Alan R.

Chemotactic cells, including neutrophils and Dictyostelium discoideum, orient and move directionally in very shallow chemical gradients. As cells polarize, distinct structural and signaling...

A Small Number of Cistrons for Ribosomal RNA in the Germinal Nucleus of a Eukaryote, Tetrahymena pyriformis

Yao, Meng-Chao, Kimmel, Alan R., Gorovsky, Martin A.

The percentage of DNA complementary to 25S and 17S rRNA has been determined for both the macro- and micronucleus of the ciliated protozoan, Tetrahymena pyriformis. Saturation levels obtained by...

A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system

Faix, Jan, Kreppel, Lisa, Shaulsky, Gad, Schleicher, Michael, Kimmel, Alan R.

Dictyostelium discoideum has proven an exceptionally powerful system for studying numerous aspects of cellular and developmental functions. The relatively small (∼34 Mb) chromosomal genome of...

A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms

Khurana, Taruna, Brzostowski, Joseph A, Kimmel, Alan R

We have identified two LIM domain proteins, LimF and ChLim, from Dictyostelium that interact with each other and with the small, Rab5-related, Rab21 GTPase to collectively regulate phagocytosis. To...

Nonadaptive Regulation of ERK2 in Dictyostelium: Implications for Mechanisms of cAMP Relay

Brzostowski, Joseph A., Kimmel, Alan R.

It is assumed that ERK2 in Dictyostelium is subject to adaptive regulation in response to constant extracellular ligand stimulation. We now show, to the contrary, that ERK2 remains active under...

Genomic database resources for Dictyostelium discoideum

Kreppel, Lisa, Kimmel, Alan R.

Dictyostelium is an attractive model system for the study of mechanisms basic to cellular function or complex multicellular developmental processes. Recent advances in Dictyostelium genomics have...

dictyBase: a new Dictyostelium discoideum genome database

Kreppel, Lisa, Fey, Petra, Gaudet, Pascale, Just, Eric, Kibbe, Warren A., Chisholm, Rex L., ...

Dictyostelium discoideum is a powerful and genetically tractable model system used for the study of numerous cellular molecular mechanisms including chemotaxis, phagocytosis and signal transduction....

Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium

Ginsburg, Gail T., Kimmel, Alan R.

Early during Dictyostelium development a fundamental cell-fate decision establishes the anteroposterior (prestalk/prespore) axis. Signaling via the 7-transmembrane cAMP receptor CAR4 is essential for...

A Gα-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement

Brzostowski, Joseph A., Parent, Carole A., Kimmel, Alan R.

Chemotactic cells, including neutrophils and Dictyostelium discoideum, orient and move directionally in very shallow chemical gradients. As cells polarize, distinct structural and signaling...

A Small Number of Cistrons for Ribosomal RNA in the Germinal Nucleus of a Eukaryote, Tetrahymena pyriformis

Yao, Meng-Chao, Kimmel, Alan R., Gorovsky, Martin A.

The percentage of DNA complementary to 25S and 17S rRNA has been determined for both the macro- and micronucleus of the ciliated protozoan, Tetrahymena pyriformis. Saturation levels obtained by...

A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system

Faix, Jan, Kreppel, Lisa, Shaulsky, Gad, Schleicher, Michael, Kimmel, Alan R.

Dictyostelium discoideum has proven an exceptionally powerful system for studying numerous aspects of cellular and developmental functions. The relatively small (∼34 Mb) chromosomal genome of...

A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms

Khurana, Taruna, Brzostowski, Joseph A, Kimmel, Alan R

We have identified two LIM domain proteins, LimF and ChLim, from Dictyostelium that interact with each other and with the small, Rab5-related, Rab21 GTPase to collectively regulate phagocytosis. To...

Nonadaptive Regulation of ERK2 in Dictyostelium: Implications for Mechanisms of cAMP Relay

Brzostowski, Joseph A., Kimmel, Alan R.

It is assumed that ERK2 in Dictyostelium is subject to adaptive regulation in response to constant extracellular ligand stimulation. We now show, to the contrary, that ERK2 remains active under...

Diverse Cytopathologies in Mitochondrial Disease Are Caused by AMP-activated Protein Kinase Signaling

Bokko, Paul B., Francione, Lisa, Bandala-Sanchez, Esther, Ahmed, Afsar U., Annesley, Sarah J., Huang, Xiuli, ...

The complex cytopathology of mitochondrial diseases is usually attributed to insufficient ATP. AMP-activated protein kinase (AMPK) is a highly sensitive cellular energy sensor that is stimulated by...

Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation

Sztalryd, Carole, Xu, Guoheng, Dorward, Heidi, Tansey, John T., Contreras, Juan A., Kimmel, Alan R., ...

Akey step in lipolytic activation of adipocytes is the translocation of hormone-sensitive lipase (HSL) from the cytosol to the surface of the lipid storage droplet. Adipocytes from perilipin-null...