Alan S. Beedle

Impaired Perinatal Growth and Longevity: A Life History Perspective (2009)

Deborah M. Sloboda, Alan S. Beedle, Cinda L. Cupido, Peter D. Gluckman, Mark H. Vickers

Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual...

Impaired Perinatal Growth and Longevity: A Life History Perspective (2009)

Deborah M. Sloboda, Alan S. Beedle, Cinda L. Cupido, Peter D. Gluckman, Mark H. Vickers

Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status (2007)

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Migrating ovaries: early life influences on later gonadal function (2007)

Gluckman, Peter D., Beedle, Alan S.

Progress in the biomedical and clinical sciences has relied heavily on experimental animal research. However, the impact of other comparative disciplines such as evolutionary biology, and in...

Leptin reversal of the metabolic phenotype: evidence for the role of developmental plasticity in the development of the metabolic syndrome (2007)

Gluckman, Peter D., Beedle, Alan S., Hanson, Mark A., Vickers, Mark H.

Events in early life are associated with changes in the risk of disease in later life. There is increasing evidence that these associations are mediated by permanent transcriptional changes in...

Low birthweight and subsequent obesity in Japan (2007)

Gluckman, Peter D., Seng, Chong Y., Fukuoka, Hideoki, Beedle, Alan S., Hanson, Mark A.

The Lancet's World Report (Feb 10, p 451)1 rightly highlights the growing epidemic of obesity in Japan—a pattern that is also seen in other Asian countries and which might be of concern for future...

Some properties and a suggested reclassification of mevaldate reductase

Beedle, Alan S., Rees, Huw H., Goodwin, Trevor W.

Mevaldate reductase was purified 70-fold from rat liver. The partly purified enzyme had a molecular weight of 27000–30000, reduced certain aromatic aldehydes and was inhibited by barbiturates....

Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol

Beedle, Alan S., Munday, Kenneth A., Wilton, David C.

Tetrahymanol biosynthesis by the protozoan Tetrahymena pyriformis was progressively inhibited by the inclusion of cholesterol in the growth medium. Studies with labelled precursors of tetrahymanol...

Some properties and a suggested reclassification of mevaldate reductase

Beedle, Alan S., Rees, Huw H., Goodwin, Trevor W.

Mevaldate reductase was purified 70-fold from rat liver. The partly purified enzyme had a molecular weight of 27000–30000, reduced certain aromatic aldehydes and was inhibited by barbiturates....

Studies on the biosynthesis of tetrahymanol in Tetrahymena pyriformis. The mechanism of inhibition by cholesterol

Beedle, Alan S., Munday, Kenneth A., Wilton, David C.

Tetrahymanol biosynthesis by the protozoan Tetrahymena pyriformis was progressively inhibited by the inclusion of cholesterol in the growth medium. Studies with labelled precursors of tetrahymanol...

Migrating Ovaries: Early Life Influences on Later Gonadal Function

Gluckman, Peter D, Beedle, Alan S

The authors discuss a new study of Bangladeshi migrants to the UK, which found that adult women who had migrated before the age of 8 years had greater luteal phase progesterone secretion than those...

Metabolic plasticity during mammalian development is directionally dependent on early nutritional status

Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...

Impaired Perinatal Growth and Longevity: A Life History Perspective

Sloboda, Deborah M., Beedle, Alan S., Cupido, Cinda L., Gluckman, Peter D., Vickers, Mark H.

Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual...