Li, Yunsen, Teneberg, Susann, Thapa, Prakash, Bendelac, Albert, Levery, Steven B., Zhou, Dapeng
Glycosphingolipids serve as ligands for receptors involved in signal transduction and immune recognition, as exemplified by isoglobotrihexosylceramide, an antigenic ligand for T cell receptors....
α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria
Gonzalez-Aseguinolaza, Gloria, De Oliveira, Camila, Tomaska, Margaret, Hong, Seokmann, Bruna-Romero, Oscar, Nakayama, Toshinori, ...
Natural killer T (NKT) cells are a unique population of lymphocytes that coexpress a semiinvariant T cell and natural killer cell receptors, which are particularly abundant in the liver. To...
Oliveira, Sofia A., Park, Se-Ho, Lee, Peter, Bendelac, Albert, Shenk, Thomas E.
The murine cytomegalovirus m02 gene family encodes putative type I membrane glycoproteins named m02 through m16. A subset of these genes were fused to an epitope tag and cloned into an expression...
Testing the NKT cell hypothesis of human IDDM pathogenesis
Lee, Peter T., Putnam, Amy, Benlagha, Kamel, Teyton, Luc, Gottlieb, Peter A., Bendelac, Albert
Defects in IL-4–producing CD1d-autoreactive NKT cells have been implicated in numerous Th1-mediated autoimmune diseases, including diabetes, multiple sclerosis, rheumatoid arthritis, lupus, and...
α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria
Gonzalez-Aseguinolaza, Gloria, De Oliveira, Camila, Tomaska, Margaret, Hong, Seokmann, Bruna-Romero, Oscar, Nakayama, Toshinori, ...
Natural killer T (NKT) cells are a unique population of lymphocytes that coexpress a semiinvariant T cell and natural killer cell receptors, which are particularly abundant in the liver. To...
Oliveira, Sofia A., Park, Se-Ho, Lee, Peter, Bendelac, Albert, Shenk, Thomas E.
The murine cytomegalovirus m02 gene family encodes putative type I membrane glycoproteins named m02 through m16. A subset of these genes were fused to an epitope tag and cloned into an expression...
Testing the NKT cell hypothesis of human IDDM pathogenesis
Lee, Peter T., Putnam, Amy, Benlagha, Kamel, Teyton, Luc, Gottlieb, Peter A., Bendelac, Albert
Defects in IL-4–producing CD1d-autoreactive NKT cells have been implicated in numerous Th1-mediated autoimmune diseases, including diabetes, multiple sclerosis, rheumatoid arthritis, lupus, and...
Schrantz, Nicolas, Sagiv, Yuval, Liu, Yang, Savage, Paul B., Bendelac, Albert, Teyton, Luc
The Niemann-Pick type C2 (NPC2) protein is a small, soluble, lysosomal protein important for cholesterol and sphingolipid transport in the lysosome. The immunological phenotype of NPC2-deficient mice...
Sagiv, Yuval, Bai, Li, Wei, Datsen G., Agami, Reuven, Savage, Paul B., Teyton, Luc, ...
Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)–resident lipid transfer protein involved in the biosynthesis and lipid loading of apolipoprotein B. MTP was recently...
Wei, Datsen G., Curran, Shane A., Savage, Paul B., Teyton, Luc, Bendelac, Albert
Mouse and human natural killer T (NKT) cells recognize a restricted set of glycosphingolipids presented by CD1d molecules, including self iGb3 and microbial α-glycuronosylceramides. The importance...
The Role of Innate Immunity in Autoimmunity
Bach, Jean-François, Bendelac, Albert, Brenner, Michael B., Cantor, Harvey, De Libero, Gennaro, Kronenberg, Mitchell, ...
During the 2004 International Congress of Immunology in Montreal, a panel of experts gathered for an “Ideashop” discussion on the potential role of innate immunity in autoimmunity and the ways in...
Characterization of the early stages of thymic NKT cell development
Benlagha, Kamel, Wei, Datsen G., Veiga, Joel, Teyton, Luc, Bendelac, Albert
Upon reaching the mature heat stable antigen (HSA)low thymic developmental stage, CD1d-restricted Vα14-Jα18 thymocytes undergo a well-characterized sequence of expansion and differentiation steps...
Wei, Datsen G., Lee, Hyunji, Park, Se-Ho, Beaudoin, Lucie, Teyton, Luc, Lehuen, Agnès, ...
Unlike conventional major histocompatibility complex–restricted T cells, Vα14-Jα18 NKT cell lineage precursors engage in cognate interactions with CD1d-expressing bone marrow–derived cells that...
Signaling for NKT cell development: the SAP–FynT connection
Borowski, Christine, Bendelac, Albert
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src...
Chiu, Ya-Hui, Jayawardena, Jayanthi, Weiss, Angela, Lee, Daniel, Park, Se-Ho, Dautry-Varsat, Alice, ...
Although recent studies have indicated that the major histocompatibility complex–like, β2-microglobulin–associated CD1 molecules might function to present a novel chemical class of antigens,...
Tilloy, Florence, Treiner, Emmanuel, Park, Se-Ho, Garcia, Corinne, Lemonnier, François, De La Salle, Henri, ...
We describe here a new subset of T cells, found in humans, mice, and cattle. These cells bear a canonical T cell receptor (TCR) α chain containing hAV7S2 and AJ33 in humans and the homologous...
The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families
Park, Se-Ho, Weiss, Angela, Benlagha, Kamel, Kyin, Tim, Teyton, Luc, Bendelac, Albert
To define the phenotype and T cell receptor (TCR) repertoire of CD1d-dependent T cells, we compared the populations of T cells that persisted in major histocompatibility complex (MHC)-deficient mice,...
Ikarashi, Yoshinori, Mikami, Rumiko, Bendelac, Albert, Terme, Magali, Chaput, Nathalie, Terada, Masahiro, ...
Given the broad expression of H-2 class Ib molecules on hematopoietic cells, antigen presentation pathways among CD1d expressing cells might tightly regulate CD1d-restricted natural killer T (NKT)...
Distinct Functional Lineages of Human Vα24 Natural Killer T Cells
Lee, Peter T., Benlagha, Kamel, Teyton, Luc, Bendelac, Albert
CD1d-restricted autoreactive natural killer (NK)T cells have been reported to regulate a range of disease conditions, including type I diabetes and immune rejection of cancer, through the secretion...
Park, Se-Ho, Guy-Grand, Delphine, Lemonnier, François A., Wang, Chyung-Ru, Bendelac, Albert, Jabri, Bana
Intestinal intraepithelial lymphocytes (IELs) in mice include two main subsets of TCR-α/β1 cells which differ functionally and ontogenically from each other. One expresses the CD8α/α homodimer,...
Lehuen, Agnès, Lantz, Olivier, Beaudoin, Lucie, Laloux, Véronique, Carnaud, Claude, Bendelac, Albert, ...
Progression to destructive insulitis in nonobese diabetic (NOD) mice is linked to the failure of regulatory cells, possibly involving T helper type 2 (Th2) cells. Natural killer (NK) T cells might be...
In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers
Benlagha, Kamel, Weiss, Angela, Beavis, Andrew, Teyton, Luc, Bendelac, Albert
The CD1 family of major histocompatibility complex (MHC)-like molecules specializes in presenting lipid and glycolipid antigens to α/β T lymphocytes, but little is known about the size of the...
Bai, Li, Sagiv, Yuval, Liu, Yang, Freigang, Stefan, Yu, Karl O. A., Teyton, Luc, ...
Short or polyunsaturated lipid variants of the NKT cell antigen α-galactosylceramide (αGC) exhibit decreased potency and a Th2 bias in vivo despite conserved TCR contact residues and stable binding...