Monte Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network (2009)
Kühn, Clemens, Wierling, Christoph, Kühn, Alexander, Klipp, Edda, Panopoulou, Georgia, Lehrach, Hans, ...
Abstract Background Gene Regulatory Networks (GRNs) control the differentiation, specification and function of cells at the genomic level. The levels of interactions within large GRNs are of enormous...
Hufton, Andrew L., Mathia, Susanne, Braun, Helene, Georgi, Udo, Lehrach, Hans, Vingron, Martin, ...
Animal genomes possess highly conserved cis-regulatory sequences that are often found near genes that regulate transcription and development. Researchers have proposed that the strong conservation of...
In-depth, high-accuracy proteomics of sea urchin tooth organic matrix (2008)
Mann, Karlheinz, Poustka, Albert J, Mann, Matthias
Abstract Background The organic matrix contained in biominerals plays an important role in regulating mineralization and in determining biomineral properties. However, most components of biomineral...
The sea urchin (Strongylocentrotus purpuratus) test and spine proteomes (2008)
Mann, Karlheinz, Poustka, Albert J, Mann, Matthias
Abstract Background The organic matrix of biominerals plays an important role in biomineral formation and in determining biomineral properties. However, most components of biomineral matrices remain...
GOblet: Annotation of anonymous sequence data with Gene Ontology and Pathway terms (2008)
Groth, Detlef, Hartmann, Stefanie, Panopoulou, Georgia, Poustka, Albert J., Hennig, Steffen
The functional annotation of genomic data has become a major task for the ever-growing number of sequencing projects. In order to address this challenge, we recently developed GOblet, a free web...
Ca 2+ signaling occurs via second messenger release from intraorganelle synthesis sites (2008)
Davis, Lianne C., Morgan, Anthony J., Ruas, Margarida, Wong, Julian L., Graef, Richard M., Poustka, Albert J., ...
Cyclic ADP-ribose is an important Ca2+-mobilizing cytosolic messenger synthesized from β-NAD+ by ADP-ribosyl cyclases (ARCs). However, the focus upon ectocellular mammalian ARCs (CD38 and CD157) has...
GOblet : annotation of anonymous sequence data with Gene Ontology and pathway terms (2008)
Groth, Detlef, Hartmann, Stefanie, Panopoulou, Georgia, Poustka, Albert J., Hennig, Steffen
The functional annotation of genomic data has become a major task for the ever-growing number of sequencing projects. In order to address this challenge, we recently developed GOblet, a free web...
Evolution of a core gene network for skeletogenesis in chordates (2008)
Hecht, Jochen, Stricker, Sigmar, Wiecha, Ulrike, Stiege, Asita, Panopoulou, Georgia, Podsiadlowski, Lars, ...
The skeleton is one of the most important features for the reconstruction of vertebrate phylogeny but few data are available to understand its molecular origin. In mammals the Runt genes are central...
Hufton, Andrew L., Groth, Detlef, Vingron, Martin, Lehrach, Hans, Poustka, Albert J., Panopoulou, Georgia
Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important...
The sea urchin (Strongylocentrotus purpuratus) test and spine proteomes (2008)
Mann, Karlheinz, Poustka, Albert J., Mann, Matthias
Background The organic matrix of biominerals plays an important role in biomineral formation and in determining biomineral properties. However, most components of biomineral matrices remain unknown...
In-depth, high-accuracy proteomics of sea urchin tooth organic matrix (2008)
Mann, Karlheinz, Poustka, Albert J., Mann, Matthias
Background The organic matrix contained in biominerals plays an important role in regulating mineralization and in determining biomineral properties. However, most components of biomineral matrices...
Hufton, Andrew L., Groth, Detlef, Vingron, Martin, Lehrach, Hans, Poustka, Albert J., Panopoulou, Georgia
Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important...
Poustka, Albert J, Kühn, Alexander, Groth, Detlef, Weise, Vesna, Yaguchi, Shunsuke, Burke, Robert D, ...
Abstract Background The genome of the sea urchin Strongylocentrotus purpuratus has recently been sequenced because it is a major model system for the study of gene regulatory networks. Embryonic...
Poustka, Albert J., Kühn, Alexander, Groth, Detlef, Weise, Vesna, Yaguchi, Shunsuke, Burke, Robert D., ...
Background The genome of the sea urchin Strongylocentrotus purpuratus has recently been sequenced because it is a major model system for the study of gene regulatory networks. Embryonic expression...
Hecht, Jochen, Kuhl, Heiner, Haas, Stefan A, Bauer, Sebastian, Poustka, Albert J, Lienau, Jasmin, ...
Abstract Background The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural...
Hecht, Jochen, Kuhl, Heiner, Haas, Stefan A ., Bauer, Sebastian, Poustka, Albert J., Lienau, Jasmin, ...
Background The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance...
Hecht, Jochen, Kuhl, Heiner, Haas, Stefan A ., Bauer, Sebastian, Poustka, Albert J., Lienau, Jasmin, ...
Background The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance...
Hecht, Jochen, Kuhl, Heiner, Haas, Stefan A ., Bauer, Sebastian, Poustka, Albert J., Lienau, Jasmin, ...
Background The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance...
Hecht, Jochen, Kuhl, Heiner, Haas, Stefan A ., Bauer, Sebastian, Poustka, Albert J., Lienau, Jasmin, ...
Background The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance...
Panopoulou, Georgia, Poustka, Albert J.
Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of...
Nodal/activin signaling establishes oral-aboral polarity in the early sea urchin embryo (2004)
Flowers,Vera Lynn, Courteau,Girard R., Poustka,Albert J., Weng,Wei, Venuti,Judith M.
Components of the Wnt signaling pathway are involved in patterning the sea urchin primary or animal-vegetal (AV) axis, but the molecular cues that pattern the secondary embryonic axis, the...
Poustka,Albert J., Kühn,Alexander, Radosavljevic,Vesna, Wellenreuther,Ruth, Lehrach,Hans, Panopoulou,Georgia
We identified a transcription factor of the onecut class in the sea urchin Strongylocentrotus purpuratus that represents an ortholog of the mammalian gene HNF6, the founding member of the onecut...
Takacs,Carter M., Amore,Gabriele, Oliveri,Paola, Poustka,Albert J., Wang,Diana, Burke,Robert D., ...
We have identified an NK2 family homeodomain transcription factor, SpNK2.1, in the sea urchin Strongylocentrotus purpuratus whose transcripts are initially detected within the apical plate ectoderm...
Coward,Kevin, Owen,Helen, Poustka,Albert J., Hibbitt,Olivia, Tunwell,Richard, Kubota,Hiroki, ...
Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, including fertilization and development of the embryo. One of the key mechanisms involved in...
Coward, Kevin, Owen, Helen, Poustka, Albert J., Hibbitt, Olivia, Tunwell, Richard, Kubota, Hiroki, ...
Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, including fertilization and development of the embryo. One of the key mechanisms involved in...
Nodal/activin signaling establishes oral-aboral polarity in the early sea urchin embryo (2004)
Flowers, Vera Lynn, Courteau, Girard R., Poustka, Albert J., Weng, Wei, Venuti, Judith M.
Components of the Wnt signaling pathway are involved in patterning the sea urchin primary or animal-vegetal (AV) axis, but the molecular cues that pattern the secondary embryonic axis, the...
Poustka, Albert J., Kühn, Alexander, Radosavljevic, Vesna, Wellenreuther, Ruth, Lehrach, Hans, Panopoulou, Georgia
We identified a transcription factor of the onecut class in the sea urchin Strongylocentrotus purpuratus that represents an ortholog of the mammalian gene HNF6, the founding member of the onecut...
Takacs, Carter M., Amore, Gabriele, Oliveri, Paola, Poustka, Albert J., Wang, Diana, Burke, Robert D., ...
We have identified an NK2 family homeodomain transcription factor, SpNK2.1, in the sea urchin Strongylocentrotus purpuratus whose transcripts are initially detected within the apical plate ectoderm...
Poustka,Albert J., Groth,Detlef, Hennig,Steffen, Thamm,Sabine, Cameron,Andrew, Beck,Alfred, ...
Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...
Panopoulou,Georgia, Hennig,Steffen, Groth,Detlef, Krause,Antje, Poustka,Albert J., Herwig,Ralf, ...
The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...
Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...
Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...
Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...
The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...
Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...
The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...
Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...
Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...
Rast,Jonathan P., Cameron,R. Andrew, Poustka,Albert J., Davidson,Eric H.
Brachyury is a transcription factor that functions in gastrulation and endoderm development throughout the Bilateria. Here, we identify genes that are expressed downstream of brachyury during...
Rast,Jonathan P., Cameron,R. Andrew, Poustka,Albert J., Davidson,Eric H.
Brachyury is a transcription factor that functions in gastrulation and endoderm development throughout the Bilateria. Here, we identify genes that are expressed downstream of brachyury during...
Rast, Jonathan P., Cameron, R. Andrew, Poustka, Albert J., Davidson, Eric H.
Brachyury is a transcription factor that functions in gastrulation and endoderm development throughout the Bilateria. Here, we identify genes that are expressed downstream of brachyury during...
Rast, Jonathan P., Cameron, R. Andrew, Poustka, Albert J., Davidson, Eric H.
Brachyury is a transcription factor that functions in gastrulation and endoderm development throughout the Bilateria. Here, we identify genes that are expressed downstream of brachyury during...
A sea urchin genome project: Sequence scan, virtual map, and additional resources (2000)
Cameron, R. Andrew, Mahairas, Gregory, Rast, Jonathan P., Martinez, Pedro, Biondi, Ted R., Swartzell, Steven, ...
Results of a first-stage Sea Urchin Genome Project are summarized here. The species chosen was Strongylocentrotus purpuratus, a research model of major importance in developmental and molecular...
Large-Scale Clustering of cDNA-Fingerprinting Data (1999)
Herwig, Ralf, Poustka, Albert J., Müller, Christine, Bull, Christof, Lehrach, Hans, O'Brien, John
A sea urchin genome project: Sequence scan, virtual map, and additional resources
Cameron, R. Andrew, Mahairas, Gregory, Rast, Jonathan P., Martinez, Pedro, Biondi, Ted R., Swartzell, Steven, ...
Results of a first-stage Sea Urchin Genome Project are summarized here. The species chosen was Strongylocentrotus purpuratus, a research model of major importance in developmental and molecular...
Large-Scale Clustering of cDNA-Fingerprinting Data
Herwig, Ralf, Poustka, Albert J., Müller, Christine, Bull, Christof, Lehrach, Hans, O'Brien, John
Clustering is one of the main mathematical challenges in large-scale gene expression analysis. We describe a clustering procedure based on a sequential k-means algorithm with additional refinements...
Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...
The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...
Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...
Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...
Hecht, Jochen, Kuhl, Heiner, Haas, Stefan A, Bauer, Sebastian, Poustka, Albert J, Lienau, Jasmin, ...
A sea urchin genome project: Sequence scan, virtual map, and additional resources
Cameron, R. Andrew, Mahairas, Gregory, Rast, Jonathan P., Martinez, Pedro, Biondi, Ted R., Swartzell, Steven, ...
Results of a first-stage Sea Urchin Genome Project are summarized here. The species chosen was Strongylocentrotus purpuratus, a research model of major importance in developmental and molecular...
Large-Scale Clustering of cDNA-Fingerprinting Data
Herwig, Ralf, Poustka, Albert J., Müller, Christine, Bull, Christof, Lehrach, Hans, O'Brien, John
Clustering is one of the main mathematical challenges in large-scale gene expression analysis. We describe a clustering procedure based on a sequential k-means algorithm with additional refinements...
Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...
The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...
Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...
Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...
Hecht, Jochen, Kuhl, Heiner, Haas, Stefan A, Bauer, Sebastian, Poustka, Albert J, Lienau, Jasmin, ...
Poustka, Albert J, Kühn, Alexander, Groth, Detlef, Weise, Vesna, Yaguchi, Shunsuke, Burke, Robert D, ...
Novel territory-specific markers from the sea urchin Strongylocentrotus purpuratus have been identified using screens for genes that are differentially expressed in lithium-treated embryos, which...
Evolution of a Core Gene Network for Skeletogenesis in Chordates
Hecht, Jochen, Stricker, Sigmar, Wiecha, Ulrike, Stiege, Asita, Panopoulou, Georgia, Podsiadlowski, Lars, ...
The skeleton is one of the most important features for the reconstruction of vertebrate phylogeny but few data are available to understand its molecular origin. In mammals the Runt genes are central...
Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites
Davis, Lianne C., Morgan, Anthony J., Ruas, Margarida, Wong, Julian L., Graeff, Richard M., Poustka, Albert J., ...
Cyclic ADP-ribose is an important Ca2+-mobilizing cytosolic messenger synthesized from β-NAD+ by ADP-ribosyl cyclases (ARCs). However, the focus upon ectocellular mammalian ARCs (CD38 and CD157) has...
Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement
Hufton, Andrew L., Groth, Detlef, Vingron, Martin, Lehrach, Hans, Poustka, Albert J., Panopoulou, Georgia
Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important...