CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences (2009)
Timofeeva, Maria N., Kropp, Silke, Sauter, Wiebke, Beckmann, Lars, Rosenberger, Albert, Illig, Thomas, ...
Cytochrome P450 (CYP) enzymes, involved in metabolism of tobacco carcinogens, are also involved in estrogen metabolism and many are regulated by estrogens. These genes may thus be of relevance to...
Mittelstrass, Kirstin, Sauter, Wiebke, Rosenberger, Albert, Illig, Thomas, Timofeeva, Maria, Klopp, Norman, ...
Abstract The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2...
Rosenberger, Albert, Illig, Thomas, Korb, Katrin, Klopp, Norman, Zietemann, Vera, Wölke, Gabi, ...
Abstract Background Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the...
Rosenberger, Albert, Illig, Thomas, Korb, Katrin, Klopp, Norman, Zietemann, Vera, Wölke, Gabi, ...
Background: Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the susceptibility to...
Mittelstrass, Kirstin, Sauter, Wiebke, Rosenberger, Albert, Illig, Thomas, Timofeeva, Maria, Klopp, Norman, ...
Abstract: The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2...
Rosenberger, Albert, Sharma, Manu, Müller-Myhsok, Bertram, Gasser, Thomas, Bickeböller, Heike
Abstract Background Genome wide linkage scans have often been successful in the identification of genetic regions containing susceptibility genes for a disease. Meta analysis is used to synthesize...
Riemenschneider, Matthias, Konta, Lidija, Friedrich, Patricia, Schwarz, Sandra, Taddei, Kevin, Neff, Frauke, ...
A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21–q22. Within this region the plasminogen activator urokinase gene (PLAU) was...
Riemenschneider, Matthias, Konta, Lidija, Friedrich, Patricia, Schwarz, Sandra, Taddei, Kevin, Neff, Frauke, ...
A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21-q22. Within this region the plasminogen activator urokinase gene (PLAU) was...
Rosenberger, Albert, Janicke, Nico, Köhler, Karola, Korb, Katrin, Kulle, Bettina, Bickeböller, Heike
Abstract For the identification of susceptibility loci in complex diseases the choice of the target phenotype is very important. We compared results of genome-wide searches for linkage or for...
Wojnowski, Leszek, Kulle, Bettina, Schirmer, Markus, Schlüter, Gregor, Schmidt, Albrecht, Rosenberger, Albert, ...
Background: A significant number of patients treated with anthracyclines develop cardiotoxicity (anthracycline-induced cardiotoxicity [ACT]), mainly presenting as arrhythmias (acute ACT) or...
Nonparametric longitudinal allele-sharing model (2003)
Kulle, Bettina, Köhler, Karola, Rosenberger, Albert, Loesgen, Sabine, Bickeböller, Heike
Abstract Basically no methods are available for the analysis of quantitative traits in longitudinal genetic epidemiological studies. We introduce a nonparametric factorial design for longitudinal...
B[Beigabe:] Thesen
Nonparametric longitudinal allele-sharing model
Kulle, Bettina, Köhler, Karola, Rosenberger, Albert, Loesgen, Sabine, Bickeböller, Heike
Basically no methods are available for the analysis of quantitative traits in longitudinal genetic epidemiological studies. We introduce a nonparametric factorial design for longitudinal data on...
Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
Mittelstrass, Kirstin, Sauter, Wiebke, Rosenberger, Albert, Illig, Thomas, Timofeeva, Maria, Klopp, Norman, ...
The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a...