The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
Qvigstad, Eirik, Brattelid, Trond, Sjaastad, Ivar, Andressen, Kjetil Wessel, Krobert, Kurt A., Birkeland, Jon Arne, ...
Background: Current pharmacological treatment of congestive heart failure (CHF) addresses changes in neurohumoral stimulation or cardiac responsiveness to such stimulation. Yet, undiscovered...
Sarsero, Doreen, Russell, Fraser D., Lynham, James A., Rabnott, Glenn, Yang, Ian, Fong, Kwun M., ...
Two forms of the activated beta(1)-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists...
Sarsero, Doreen, Russell, Fraser D., Lynham, James A., Rabnott, Glenn, Yang, Ian, Fong, Kwun M., ...
Two forms of the activated beta(1)-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists...
Heubach, Jürgen F, Trebeß, Ina, Wettwer, Erich, Himmel, Herbert M, Michel, Martin C, Kaumann, Alberto J, ...
Objectives: The reported increase in basal activity of hearts from transgenic mice (TG4) overexpressing the human β2-adrenoceptor (β2-AR) was explained by spontaneously active β2-ARs that...
Herz-[beta]-Rezeptoren [Herz-beta-Rezeptoren]. (1983)
Aus: Zeitschrift für Kardiologie. 72. 1983, S. 63 - 82
Molenaar, Peter, Sarsero, Doreen, Arch, Jonathan R S, Kelly, John, Henson, Sian M, Kaumann, Alberto J
Chronic treatment of patients with β-blockers causes atrial inotropic hyperresponsiveness through β2-adrenoceptors, 5-HT4 receptors and H2-receptors but apparently not through β1-adrenoceptors...
Kaumann, Alberto J, Lynham, James A
Mammalian hearts possess an atypical β-adrenoceptor (non-β1, non-β2, non-β3) through which (–)-4-(3-t-butylamino-2-hydroxypropoxy)benzimidazol-2-one ((–)-CGP 12177) causes cardiostimulant...
Validity of (−)-[3H]-CGP 12177A as a radioligand for the ‘putative β4-adrenoceptor' in rat atrium
Sarsero, Doreen, Molenaar, Peter, Kaumann, Alberto J
We have recently suggested the existence in the heart of a ‘putative β4-adrenoceptor' based on the cardiostimulant effects of non-conventional partial agonists, compounds that cause...
Lowe, Martin D, Grace, Andrew A, Vandenberg, Jamie I, Kaumann, Alberto J
The electrophysiological responses to (−)-CGP 12177 ((−)-4-(3-tertiarybutylamino-2-hydroxypropoxy) benzimidazol-2-one), an agonist for the putative β4-adrenoceptor, were investigated on isolated...
Sarsero, Doreen, Molenaar, Peter, Kaumann, Alberto J, Freestone, Nicholas S
We identified putative β4-adrenoceptors by radioligand binding, measured increases in ventricular contractile force by (−)-CGP 12177 and (±)-cyanopindolol and demonstrated increased Ca2+...
Lowe, Martin D, Lynham, James A, Grace, Andrew A, Kaumann, Alberto J
We compared the potency of 11 clinically available β-blockers as antagonists of the positive inotropic effects of (−)-isoprenaline and CGP12177 on ferret ventricular myocardium.(−)-CGP12177,...
Heubach, Jürgen F, Rau, Thomas, Eschenhagen, Thomas, Ravens, Ursula, Kaumann, Alberto J
Murine left atrium lacks inotropic β2-adrenoceptor function. We investigated whether β2-adrenoceptors are involved in the cardiostimulant effects of (−)-adrenaline on spontaneously beating right...
Kaumann, Alberto J, Levy, Finn Olav
Inotropic responses to 5-hydroxytryptamine (5-HT) in human and porcine atrium can fade, suggesting 5-HT4 receptor desensitization. De Maeyer et al., however, show in this issue that inhibition of...
Vargas, Maria Luisa, Hernandez, Jesus, Kaumann, Alberto J
The cardiostimulant effects of CGP12177, mediated through a β1-adrenoceptor site with low affinity for (−)-propranolol, are potentiated by the nonselective PDE inhibitor IBMX but the role of PDE...
Verheggen, Raphaela, Bumann, Katja, Kaumann, Alberto J
Release of CGRP during migraine may produce harmful dilatation of cranial arteries, thereby possibly causing pain. We have compared the antagonism by BIBN4096BS and CGRP(8-37) of the relaxant effects...
Merritt, Janet E., Hallam, Trevor J., Brown, Anthony M., Boyfield, Isobel, Cooper, David G., Hickey, Deirdre M.B., ...
1 Octimibate, 8-[(1,4,5-triphenyl-1H-imidazol-2-yl)oxy]octanoic acid, is reported to have antihrombotic properties, This is in addition to its antihyperlipidaemic effects which are due to inhibition...
Primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor
Merritt, Janet E., Brown, Anthony M., Bund, Stuart, Cooper, David G., Egan, John W., Hallam, Trevor J., ...
1 Octimibate is a potent inhibitor of human platelet aggregation, and appears to act (at least in part) through the prostacyclin receptor, as described in the preceding paper. Here, the vascular...