Alex Almasan

Redox Regulation of Apoptosis before and after Cytochrome C Release (2008)

Chen, Quan, Crosby, Meredith, Almasan, Alex

Programmed cell death, or apoptosis, is one of the most studied areas of modern biology. Apoptosis is a genetically regulated process, which plays an essential role in the development and homeostasis...

Cellular Commitment to Radiation-Induced Apoptosis (2000)

Alex Almasan

Almasan, A. Cellular Commitment to Radiation-Induced Apoptosis. The basic elements of the machinery of programmed cell death (apoptosis) are built into all mammalian cells and are conserved...

Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines

Matsuda, Takehiro, Almasan, Alex, Tomita, Mariko, Uchihara, Jun-nosuke, Masuda, Masato, Ohshiro, Kazuiku, ...

Adult T-cell leukemia (ATL), a CD4+-T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1), is difficult to cure, and novel treatments are urgently needed. Apo2 ligand (Apo2L; also...

Redox Regulation of Apoptosis before and after Cytochrome C Release

Chen, Quan, Crosby, Meredith, Almasan, Alex

Programmed cell death, or apoptosis, is one of the most studied areas of modern biology. Apoptosis is a genetically regulated process, which plays an essential role in the development and homeostasis...

Apo2 Ligand/TNF-related Apoptosis-inducing Ligand and Death Receptor 5 Mediate the Apoptotic Signaling Induced by Ionizing Radiation in Leukemic Cells1

Gong, Bendi, Almasan, Alex

Ionizing radiation is a major tool for cancer treatment. The response of eukaryotic cells to ionizing radiation includes apoptosis, a process which requires activation of multiple genes. We sought to...

Apoptosis Induction in Prostate Cancer Cells and Xenografts by Combined Treatment with Apo2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand and CPT-111

Ray, Subrata, Almasan, Alex

Because apoptosis is deregulated in most cancers, apoptosis-modulating approaches offer an attractive opportunity for clinical therapy of many tumors, including that of the prostate. LNCaP-derived...

Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines

Matsuda, Takehiro, Almasan, Alex, Tomita, Mariko, Uchihara, Jun-nosuke, Masuda, Masato, Ohshiro, Kazuiku, ...

Adult T-cell leukemia (ATL), a CD4+-T-cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1), is difficult to cure, and novel treatments are urgently needed. Apo2 ligand (Apo2L; also...