Alex Parker

Haplotype Transmission Analysis Provides Evidence of Association for DISC1 to Schizophrenia and Suggests Sex-Dependent Effects (2003)

Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...

We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects (2003)

Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...

We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...

Haplotype Transmission Analysis Provides Evidence of Association for DISC1 to Schizophrenia and Suggests Sex-Dependent Effects (2003)

Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...

We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...

Chromosome 1 loci in Finnish schizophrenia families (2001)

Ekelund, Jesper, Hovatta, Iiris, Parker, Alex, Paunio, Tiina, Varilo, Teppo, Martin, Rory, ...

We have earlier reported evidence for linkage to two regions on chromosome 1q32–q42 in schizophrenia families collected for two separate studies in Finland. Here we report the results of a fine...

Binding of Insulin-like Growth Factor (IGF)–Binding Protein-5 to Smooth-Muscle Cell Extracellular Matrix Is a Major Determinant of the Cellular Response to IGF-I

Parker, Alex, Rees, Catherine, Clarke, Jane, Busby, Walker H., Clemmons, David R.

Insulin-like growth factor–binding protein-5 (IGFBP-5) has been shown to bind to fibroblast extracellular matrix (ECM). Extracellular matrix binding of IGFBP-5 leads to a decrease in its affinity...

Genomewide Linkage Analysis of Stature in Multiple Populations Reveals Several Regions with Evidence of Linkage to Adult Height

Hirschhorn, Joel N., Lindgren, Cecilia M., Daly, Mark J., Kirby, Andrew, Schaffner, Stephen F., Burtt, Noel P., ...

Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common...

A Genomewide Search for Quantitative-Trait Loci Underlying Asthma

Xu, Xin, Fang, Zhian, Wang, Binyan, Chen, Changzhong, Guang, Wenwei, Jin, Yongtang, ...

A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes...

Binding of Insulin-like Growth Factor (IGF)–Binding Protein-5 to Smooth-Muscle Cell Extracellular Matrix Is a Major Determinant of the Cellular Response to IGF-I

Parker, Alex, Rees, Catherine, Clarke, Jane, Busby, Walker H., Clemmons, David R.

Insulin-like growth factor–binding protein-5 (IGFBP-5) has been shown to bind to fibroblast extracellular matrix (ECM). Extracellular matrix binding of IGFBP-5 leads to a decrease in its affinity...

Genomewide Linkage Analysis of Stature in Multiple Populations Reveals Several Regions with Evidence of Linkage to Adult Height

Hirschhorn, Joel N., Lindgren, Cecilia M., Daly, Mark J., Kirby, Andrew, Schaffner, Stephen F., Burtt, Noel P., ...

Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common...

A Genomewide Search for Quantitative-Trait Loci Underlying Asthma

Xu, Xin, Fang, Zhian, Wang, Binyan, Chen, Changzhong, Guang, Wenwei, Jin, Yongtang, ...

A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes...

Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study

Ridker, Paul M., Pare, Guillaume, Parker, Alex, Zee, Robert Y.L., Danik, Jacqueline S., Buring, Julie E., ...

Although elevated levels of C-reactive protein (CRP) independently predict increased risk of development of metabolic syndrome, diabetes, myocardial infarction, and stroke, comprehensive analysis of...

Genome-Wide Association Study of Determinants of Anti-Cyclic Citrullinated Peptide Antibody Titer in Adults with Rheumatoid Arthritis

Cui, Jing, Taylor, Kimberly E, DeStefano, Anita L, Criswell, Lindsey A, Izmailova, Elena S, Parker, Alex, ...

We carried out a genome-wide association study of genetic predictors of anti-cyclic citrullinated peptide antibody (anti-CCP) level in 531 self-reported non-Hispanic Caucasian Rheumatoid Arthritis...