The role of NFAT transcription factors in integrin-mediated carcinoma invasion. (2002)
Jauliac, Sebastien, Lopez-Rodriguez, Cristina, Shaw, Leslie, Brown, Lawrence, Rao, Anjana, Toker, Alex
Integrins, receptors for extracellular matrix ligands, are critical regulators of the invasive phenotype. Specifically, the alpha(6)beta(4) integrin has been linked with epithelial cell motility,...
Klingmüller, Ursula, Wu, Hong, Hsiao, Jonathan G., Toker, Alex, Duckworth, Brian C., Cantley, Lewis C., ...
Homodimerization of the erythropoietin (EPO) receptor (EPO-R) in response to EPO binding transiently activates the receptor-associated protein tyrosine kinase JAK2. Tyrosine phosphorylation of the...
Romanelli, Angela, Martin, Kathleen A., Toker, Alex, Blenis, John
p70 S6 kinase (p70S6K) is an important regulator of cell proliferation. Its activation by growth factor requires phosphorylation by various inputs on multiple sites. Data accumulated thus far support...
Protein kinase D mediates a stress-induced NF-κB activation and survival pathway
The activation of the transcription factor NF-κB is critical for a number of physiological responses. Here, we provide evidence for a signaling pathway that mediates NF-κB activation in response to...
Paradis, Suzanne, Ailion, Michael, Toker, Alex, Thomas, James H., Ruvkun, Gary
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1...
Storz, Peter, Döppler, Heike, Toker, Alex
Protein kinase D (PKD) participates in activation of the transcription factor NF-κB (nuclear factor κB) in cells exposed to oxidative stress, leading to increased cellular survival. We previously...
Functional dichotomy of A20 in apoptotic and necrotic cell death
Storz, Peter, Döppler, Heike, Ferran, Christiane, Grey, Shane T., Toker, Alex
ROS (reactive oxygen species) play important roles in the progression of a number of human pathologies. ROS promote cell death, but can also induce gene transcription. The transcription factor NF-κB...
Regulation of novel protein kinase C epsilon by phosphorylation.
Cenni, Vittoria, Döppler, Heike, Sonnenburg, Erica D, Maraldi, Nadir, Newton, Alexandra C, Toker, Alex
The activity and intracellular localization of protein kinase C (PKC) family members are controlled by phosphorylation at three highly conserved sites in the catalytic kinase domain. In the case of...
Storz, Peter, Döppler, Heike, Toker, Alex
Efficient elimination of mitochondrial reactive oxygen species (mROS) correlates with increased cellular survival and organism life span. Detoxification of mitochondrial ROS is regulated by induction...
The biology and biochemistry of diacylglycerol signalling
Meeting on Molecular Advances in Diacylglycerol Signalling
Hausser, Angelika, Märtens, Susanne, Link, Gisela, Pfizenmaier, Klaus, Storz, Peter, Toker, Alex
Protein kinase D (PKD) regulates the fission of vesicles from the trans-Golgi-network1,2. We show that phosphatidylinositol-4-kinase III beta (PI4KIIIβ), a key player in Golgi complex structure and...
Klingmüller, Ursula, Wu, Hong, Hsiao, Jonathan G., Toker, Alex, Duckworth, Brian C., Cantley, Lewis C., ...
Homodimerization of the erythropoietin (EPO) receptor (EPO-R) in response to EPO binding transiently activates the receptor-associated protein tyrosine kinase JAK2. Tyrosine phosphorylation of the...
Romanelli, Angela, Martin, Kathleen A., Toker, Alex, Blenis, John
p70 S6 kinase (p70S6K) is an important regulator of cell proliferation. Its activation by growth factor requires phosphorylation by various inputs on multiple sites. Data accumulated thus far support...
Protein kinase D mediates a stress-induced NF-κB activation and survival pathway
The activation of the transcription factor NF-κB is critical for a number of physiological responses. Here, we provide evidence for a signaling pathway that mediates NF-κB activation in response to...
Paradis, Suzanne, Ailion, Michael, Toker, Alex, Thomas, James H., Ruvkun, Gary
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1...
Storz, Peter, Döppler, Heike, Toker, Alex
Protein kinase D (PKD) participates in activation of the transcription factor NF-κB (nuclear factor κB) in cells exposed to oxidative stress, leading to increased cellular survival. We previously...
Functional dichotomy of A20 in apoptotic and necrotic cell death
Storz, Peter, Döppler, Heike, Ferran, Christiane, Grey, Shane T., Toker, Alex
ROS (reactive oxygen species) play important roles in the progression of a number of human pathologies. ROS promote cell death, but can also induce gene transcription. The transcription factor NF-κB...
Regulation of novel protein kinase C epsilon by phosphorylation.
Cenni, Vittoria, Döppler, Heike, Sonnenburg, Erica D, Maraldi, Nadir, Newton, Alexandra C, Toker, Alex
The activity and intracellular localization of protein kinase C (PKC) family members are controlled by phosphorylation at three highly conserved sites in the catalytic kinase domain. In the case of...
Storz, Peter, Döppler, Heike, Toker, Alex
Efficient elimination of mitochondrial reactive oxygen species (mROS) correlates with increased cellular survival and organism life span. Detoxification of mitochondrial ROS is regulated by induction...
The biology and biochemistry of diacylglycerol signalling
Meeting on Molecular Advances in Diacylglycerol Signalling
Rabinovitz, Isaac, Toker, Alex, Mercurio, Arthur M.
We explored the hypothesis that the chemotactic migration of carcinoma cells that assemble hemidesmosomes involves the activation of a signaling pathway that releases the α6β4 integrin from these...
Watkins, Janis L., Lewandowski, Katherine T., Meek, Sarah E. M., Storz, Peter, Toker, Alex, Piwnica-Worms, Helen
The Par-1 protein kinases are conserved from yeast to humans, where they function as key polarity determinants. The mammalian Par-1 family is comprised of 4 members (Par-1a, -b, -c, and -d)....