Prediction of structures of multidomain proteins from structures of the individual domains (2007)
Wollacott, Andrew M., Zanghellini, Alexandre, Murphy, Paul, Baker, David
We describe the development of a method for assembling structures of multidomain proteins from structures of isolated domains. The method consists of an initial low-resolution search in which the...
Access the most recent version at doi: 10.1110/ps.062353106 References (2006)
Re Zanghellini, Lin Jiang, Andrew M. Wollacott, Gong Cheng, Jens Meiler, Eric A. Althoff, ...
New algorithms and an in silico benchmark for computational
Re Zanghellini, Lin Jiang, Andrew M. Wollacott, Gong Cheng, Jens Meiler, Eric A. Althoff, ...
New algorithms and an in silico benchmark for computational
Prediction of structures of multidomain proteins from structures of the individual domains (2006)
Wollacott, Andrew M., Zanghellini, Alexandre, Murphy, Paul, Baker, David
We describe the development of a method for assembling structures of multidomain proteins from structures of isolated domains. The method consists of an initial low-resolution search in which the...
New algorithms and an in silico benchmark for computational enzyme design (2006)
Zanghellini, Alexandre, Jiang, Lin, Wollacott, Andrew M., Cheng, Gong, Meiler, Jens, Althoff, Eric A., ...
The creation of novel enzymes capable of catalyzing any desired chemical reaction is a grand challenge for computational protein design. Here we describe two new algorithms for enzyme design that...
Prediction of structures of multidomain proteins from structures of the individual domains (2006)
Wollacott, Andrew M., Zanghellini, Alexandre, Murphy, Paul, Baker, David
We describe the development of a method for assembling structures of multidomain proteins from structures of isolated domains. The method consists of an initial low-resolution search in which the...
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells (2003)
Epinat, Jean-Charles, Arnould, Sylvain, Chames, Patrick, Rochaix, Pascal, Desfontaines, Dominique, Puzin, Clémence, ...
Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site‐ specific DNA double‐strand breaks...
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
Epinat, Jean-Charles, Arnould, Sylvain, Chames, Patrick, Rochaix, Pascal, Desfontaines, Dominique, Puzin, Clémence, ...
Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site- specific DNA double-strand breaks (DSBs) have...
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
Epinat, Jean-Charles, Arnould, Sylvain, Chames, Patrick, Rochaix, Pascal, Desfontaines, Dominique, Puzin, Clémence, ...
Homologous gene targeting is the ultimate tool for reverse genetics, but its use is often limited by low efficiency. In a number of recent studies, site- specific DNA double-strand breaks (DSBs) have...
Prediction of structures of multidomain proteins from structures of the individual domains
Wollacott, Andrew M., Zanghellini, Alexandre, Murphy, Paul, Baker, David
We describe the development of a method for assembling structures of multidomain proteins from structures of isolated domains. The method consists of an initial low-resolution search in which the...
New algorithms and an in silico benchmark for computational enzyme design
Zanghellini, Alexandre, Jiang, Lin, Wollacott, Andrew M., Cheng, Gong, Meiler, Jens, Althoff, Eric A., ...
The creation of novel enzymes capable of catalyzing any desired chemical reaction is a grand challenge for computational protein design. Here we describe two new algorithms for enzyme design that...