Alexandru Almasan

Microarray gene expression profiling and analysis in renal cell carcinoma (2004)

Liou, Louis S, Shi, Ting, Duan, Zhong-Hui, Sadhukhan, Provash, Der, Sandy D, Novick, Andrew A, ...

Abstract Background Renal cell carcinoma (RCC) is the most common cancer in adult kidney. The accuracy of current diagnosis and prognosis of the disease and the effectiveness of the treatment for the...

Characterization of a novel plasmid-like element in Neurospora crassa derived mostly from the mitochondrial DNA (1990)

Almasan, Alexandru, Mishra, Nawin C.

We have identified a plasmld-like element within mitochondria ofNeurospora crassa strain stp-B1. R is derived from the EcoRI-4 and EcoRI-6 regions of the mitochondrlai DNA, and an additional 124 bp...

Intramolecular recombination in the mtDNA of neurospora crassa /--by Alexandru Almasan. (1989)

Almasan, Alexandru.

Typescript.

Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage

Paulson, Thomas G., Almasan, Alexandru, Brody, Linnea L., Wahl, Geoffrey M.

Amplification of genes involved in signal transduction and cell cycle control occurs in a significant fraction of human cancers. Loss of p53 function has been proposed to enable cells with gene...

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...

Microarray gene expression profiling and analysis in renal cell carcinoma

Liou, Louis S, Shi, Ting, Duan, Zhong-Hui, Sadhukhan, Provash, Der, Sandy D, Novick, Andrew A, ...

Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells

Mazumder, Suparna, Gong, Bendi, Almasan, Alexandru

Cyclin E is essential for progression through the G1 phase of the cell cycle and initiation of DNA replication by interacting with, and activating its catalytic partner, the cyclin-dependent kinase 2...

Apoptosis of Multiple Myeloma

Oancea, Marcela, Mani, Aruna, Hussein, Mohamad A, Almasan, Alexandru

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. MM cells localize to the bone marrow, where cell adhesion–mediated autocrine or paracrine activation of various...

Role of Apo2L/TRAIL and Bcl-2-family Proteins in Apoptosis of Multiple Myeloma*

CHEN, QUAN, RAY, SUBRATA, HUSSEIN, MOHAMAD A., SRKALOVIC, GORDAN, ALMASAN, ALEXANDRU

Apo2 Ligand or Tumour Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (Apo2L/TRAIL) is a member of the TNF gene superfamily that selectively induces apoptosis in tumor cells of diverse...

Apo2L/TRAIL and Bcl-2–related proteins regulate type I interferon–induced apoptosis in multiple myeloma

Chen, Quan, Gong, Bendi, Mahmoud-Ahmed, Ashraf S., Zhou, Aimin, Hsi, Eric D., Hussein, Mohamad, ...

It has been reported that interferons (IFNs) may have antitumor activity in multiple myeloma (MM). The mechanism for their effect on MM, however, remains elusive. This study shows that IFN-α and...

Genotoxic Stress Induces Expression of E2F4, Leading to Its Association with p130 in Prostate Carcinoma Cells

DuPree, Erica L., Mazumder, Suparna, Almasan, Alexandru

The retinoblastoma (pRb), p107, and p130 pocket proteins bind to the E2F transcription factors to control gene expression. E2F4 protein levels increased and accumulated in the nuclei of prostate...

Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage

Paulson, Thomas G., Almasan, Alexandru, Brody, Linnea L., Wahl, Geoffrey M.

Amplification of genes involved in signal transduction and cell cycle control occurs in a significant fraction of human cancers. Loss of p53 function has been proposed to enable cells with gene...

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...

Microarray gene expression profiling and analysis in renal cell carcinoma

Liou, Louis S, Shi, Ting, Duan, Zhong-Hui, Sadhukhan, Provash, Der, Sandy D, Novick, Andrew A, ...

Superoxide Dismutase Inactivation in Pathophysiology of Asthmatic Airway Remodeling and Reactivity

Comhair, Suzy A.A., Xu, Weiling, Ghosh, Sudakshina, Almasan, Alexandru, Calhoun, William J., ...

Airway hyperresponsiveness and remodeling are defining features of asthma. We hypothesized that impaired superoxide dismutase (SOD) antioxidant defense is a primary event in the pathophysiology of...

Interaction of a Cyclin E Fragment with Ku70 Regulates Bax-Mediated Apoptosis▿ †

Mazumder, Suparna, Plesca, Dragos, Kinter, Michael, Almasan, Alexandru

The cyclin E/Cdk2 complex plays an essential role in the G1/S cell cycle transition and DNA replication. Earlier we showed that in hematopoietic tumor cells, caspase-mediated cleavage of cyclin E...

A C-terminal Fragment of Cyclin E, Generated by Caspase-mediated Cleavage, Is Degraded in the Absence of a Recognizable Phosphodegron*

Plesca, Dragos, Mazumder, Suparna, Gama, Vivian, Matsuyama, Shigemi, Almasan, Alexandru

We have previously shown that caspase-mediated cleavage of Cyclin E generates p18-Cyclin E in hematopoietic tumor cells. Its expression can induce apoptosis or sensitize to apoptotic stimuli in many...