Alf Giese

Identification and Validation of P311 as a Glioblastoma Invasion Gene Using Laser Capture Microdissection 1 (2008)

Luigi Mariani, Wendy S. Mcdonough, Dominique B. Hoelzinger, Christian Beaudry, Elzbieta Kaczmarek, Stephen W. Coons, ...

The mRNA expression profiles from glioblastoma cells residing at the tumor core and invasive rim of a human tumor resection were compared. From a single tumor specimen, 20,000 single cells from each...

Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme (2007)

Holtkamp, Nikola, Ziegenhagen, Nicolas, Malzer, Elke, Hartmann, Christian, Giese, Alf, Von Deimling, Andreas

A subset of glioblastomas (GBMs) carry gene amplifications on chromosomal segment 4q12. To characterize this amplicon in detail, we analyzed a set of 100 samples consisting of 65 GBMs, 10 WHO grade...

Preoperative thrombocytosis predicts poor survival in patients with glioblastoma (2007)

Brockmann, Marc A., Giese, Alf, Mueller, Kathrin, Kaba, Finjap Janvier, Lohr, Frank, Weiss, Christel, ...

Thrombocytosis, which is defined as a platelet count greater than 400 platelets/nl, has been found to be an independent predictor of shorter survival in various tumors. Release of growth factors from...

Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo (2007)

Kantelhardt, Sven R., Leppert, Jan, Krajewski, Jochen, Petkus, Nadine, Reusche, Erich, Tronnier, Volker M., ...

Multiphoton excitation fluorescent microscopy is a laser-based technology that allows subcellular resolution of native tissues in situ. We have recently applied this technology to the structural and...

Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo (2007)

Kantelhardt, Sven R., Leppert, Jan, Krajewski, Jochen, Petkus, Nadine, Reusche, Erich, Tronnier, Volker M., ...

Multiphoton excitation fluorescent microscopy is a laser-based technology that allows subcellular resolution of native tissues in situ. We have recently applied this technology to the structural and...

Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo (2007)

Kantelhardt, Sven R., Leppert, Jan, Krajewski, Jochen, Petkus, Nadine, Reusche, Erich, Tronnier, Volker M., ...

Multiphoton excitation fluorescent microscopy is a laser-based technology that allows subcellular resolution of native tissues in situ. We have recently applied this technology to the structural and...

Thromboxane synthase regulates the migratory phenotype of human glioma cells (1999)

Giese, Alf, Hagel, Christian, Kim, Ella L., Zapf, Svenja, Djawaheri, Jasmin, Berens, Michael E., ...

The capacity of glial tumor cells to migrate and diffusely infiltrate normal brain compromises surgical eradication of the disease. Identification of genes associated with invasion may offer novel...

“…those left behind.” Biology and Oncology of Invasive Glioma Cells

Berens, Michael E, Giese, Alf

Although significant technical advances in surgical and radiation treatment for brain tumors have emerged in recent years, their impact on clinical outcome for patients has been disappointing. A...

Allogeneic Astrocytoma In Immune Competent Dogs

Berens, Michael E, Giese, Alf, Shapiro, Joan R, Coons, Stephen W

We have induced in canines long-term immune tolerance to an allogeneic cell line derived from a spontaneous canine astrocytoma. Allogeneic astrocytoma cells were implanted endoscopically into the...

“…those left behind.” Biology and Oncology of Invasive Glioma Cells

Berens, Michael E, Giese, Alf

Although significant technical advances in surgical and radiation treatment for brain tumors have emerged in recent years, their impact on clinical outcome for patients has been disappointing. A...

Allogeneic Astrocytoma In Immune Competent Dogs

Berens, Michael E, Giese, Alf, Shapiro, Joan R, Coons, Stephen W

We have induced in canines long-term immune tolerance to an allogeneic cell line derived from a spontaneous canine astrocytoma. Allogeneic astrocytoma cells were implanted endoscopically into the...

Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo1

Kantelhardt, Sven R., Leppert, Jan, Krajewski, Jochen, Petkus, Nadine, Reusche, Erich, Tronnier, Volker M., ...

Multiphoton excitation fluorescent microscopy is a laser-based technology that allows subcellular resolution of native tissues in situ. We have recently applied this technology to the structural and...

Preoperative thrombocytosis predicts poor survival in patients with glioblastoma

Brockmann, Marc A., Giese, Alf, Mueller, Kathrin, Kaba, Finjap Janvier, Lohr, Frank, Weiss, Christel, ...

Thrombocytosis, which is defined as a platelet count greater than 400 platelets/nl, has been found to be an independent predictor of shorter survival in various tumors. Release of growth factors from...

Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme

Holtkamp, Nikola, Ziegenhagen, Nicolas, Malzer, Elke, Hartmann, Christian, Giese, Alf, Von Deimling, Andreas

A subset of glioblastomas (GBMs) carry gene amplifications on chromosomal segment 4q12. To characterize this amplicon in detail, we analyzed a set of 100 samples consisting of 65 GBMs, 10 WHO grade...