Sabel, Michael S., Griffith, Kent A., Rivers, Aeisha K., Chang, Alfred E., Degnim, Amy C., Cimmino, Vincent M., ...
The survival benefit of a completion axillary lymph node dissection (ALND) in patients after removal of a metastatic sentinel lymph node (SLN) is uncertain and is under study in ongoing clinical...
Newman, Erika A., Chang, Alfred E., Newman, Lisa A., Frey, Kirk A., Diehl, Kathleen M., Cimmino, Vincent M., ...
Local recurrence (LR) after breast-conservation therapy for breast cancer occurs in 10% to 15% of cases. A subset of these represents biologically aggressive disease, yet prognostic features for...
Wide excision without radiation for desmoplastic melanoma (2005)
Arora, Alisha, Lowe, Lori, Su, Lyndon D., Rees, Riley S., Bradford, Carol R., Cimmino, Vincent M., ...
BACKGROUND Adjuvant radiation has been proposed for the treatment of patients with desmoplastic melanoma, who reportedly have local recurrence rates as high as 40–60%. The authors investigated...
Kleer, Celina G., Chang, Alfred E., Hayes, Dan F., Newman, Lisa A., Cimmino, Vincent M., Nees, Alexis, ...
There is ongoing debate regarding the optimal sequence of sentinel lymph node (SLN) biopsy and neoadjuvant chemotherapy (CTX) for breast cancer. We report the accuracy of comprehensive...
Sabel, Michael S., Newman, Lisa A., Cimmino, Vincent M., Degnim, Amy C., Oh, Kevin, Diehl, Kathleen M., ...
The use of isosulfan blue dye in sentinel node biopsy for breast cancer has been questioned because of its risk of allergic reaction. We hypothesized that blue dye could be safely omitted in the...
Immunologic response to cryoablation of breast cancer (2005)
Sabel, Michael S., Nehs, Matthew A., Su, Gang, Lowler, Kathleen P., Ferrara, James L.M., Chang, Alfred E.
Purpose .With improvements in breast imaging and image-guided interventions, there is interest in ablative techniques for breast cancer. Cryosurgery initiates inflammation and leaves tumor-specific...
An academic health center cost analysis of screening mammography (2004)
Chen, Steven L., Clark, Samuel, Pierce, Lori J., Hayes, Daniel F., Helvie, Mark A., Greeno, Paula L., ...
BACKGROUND The current study sought to determine the institutional financial impact of a screening mammography (SM) program in the context of an integrated cancer center. METHODS Using administrative...
Efficacy of sentinel lymph node biopsy in male breast cancer (2004)
Cimmino, Vincent M., Degnim, Amy C., Sabel, Michael S., Diehl, Kathleen M., Newman, Lisa A., Chang, Alfred E.
Background Sentinel lymph node biopsy (SLNB) is rapidly becoming the standard of care in the treatment of women with early stage breast cancer. Male breast cancer although relatively rare, has...
Xin, Wei, Davenport, Robertson D., Chang, Alfred E., Michael, Claire W.
Total joint replacement is a common orthopedic procedure. An artificial joint implant may fail due to mechanical mishap and a granulomatous reaction can be induced by the artificial joint debris...
Moon, James, Chang, Alfred E., Sabel, Michael S., Wang, Yue, Johnson, Timothy M., Lowe, Lori, ...
Background: Sentinel lymph node (SLN) biopsy allows surgeons to identify patients with subclinical nodal involvement who may benefit from lymphadenectomy and, possibly, adjuvant therapy. Several...
Chang, Wen-Jian, Bailey, Nicola, Sabel, Michael S., Chang, Alfred E., Mathiowitz, Edith, Egilmez, Nejat K., ...
Background: Local, sustained delivery of cytokines at a tumor can enhance induction of antitumor immunity and may be a feasible neoadjuvant immunotherapy for breast cancer. We evaluated the ability...
Degnim, Amy C., Griffith, Kent A., Sabel, Michael S., Hayes, Daniel F., Cimmino, Vincent M., Diehl, Kathleen M., ...
BACKGROUND In breast carcinoma patients with a positive sentinel lymph node (SN), the value of complete axillary lymph node dissection has been questioned. Multiple published reports have attempted...
Treating Colon Cancer With a Melanoma Vaccine? Preposterous? (2001)
Chang, Alfred E., Sondak, Vernon K.
Peer Reviewed
New York, Steinkopff Darmstadt, Get This, Weeks Faster, Jeffrey A. Norton, Alfred E. Chang, ...
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New York, Steinkopff Darmstadt, Get This, Weeks Faster, Jeffrey A. Norton, Alfred E. Chang, ...
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New York, Steinkopff Darmstadt, Get This, Weeks Faster, Jeffrey A. Norton, Alfred E. Chang, ...
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Chang, Alfred E., Li, Qiao, Bishop, D. Keith, Normolle, Daniel P., Redman, Bruce D., Nickoloff, Brian J.
We performed a clinical study of five patients with melanoma to evaluate the immunobiological effects of retrovirally transduced autologous tumor cells given as a vaccine to prime draining lymph...
Gene gun application in the generation of effector T cells for adoptive immunotherapy (2000)
Tanigawa, Keishi, Sun, Rong, Chang, Alfred E., Yu, Hua, Nickoloff, Brian J.
We utilized the gene gun to transfect subcutaneous D5 melanoma and MT-901 mammary carcinoma tumors in situ with a granulocyte/macrophage-colony-stimulating factor (GM-CSF) plasmid complexed to gold...
Al-Sobhi, Saif S., Chang, Alfred E., Helvie, Mark A., Pass, Helen A.
Background: Stereotactic core biopsy of mammographically defined breast abnormalities is an alternative to wire localization biopsy. The purpose of this study was to evaluate the extent of lumpectomy...
Useful techniques for the resection of foot melanomas (1999)
Cowles, Robert A., Johnson, Timothy M., Chang, Alfred E.
No abstract.
Clinical implications of the new biology in the development of melanoma vaccines (1999)
Hemmila, Mark R., Chang, Alfred E.
There has been a resurgence in clinical research of vaccine therapies, particularly for the treatment of melanoma. The renewed interest in this field is attributable to an increased understanding...
The National Cancer Data Base report on cutaneous and noncutaneous melanoma (1998)
Chang, Alfred E., Karnell, Lucy Hynds, Menck, Herman R.
BACKGROUND This study reviews the case-mix characteristics, management, and outcomes of melanoma cases occuring in the U. S. within the last decade. METHODS Analyses of the National Cancer Data Base...
Possert, Peter W., Helvie, Mark A., Yahanda, Alan M., Oberman, Harold A., Wilkins, Edwin G., Salas, A. P., ...
Background: Skin-sparing mastectomy with immediate transverse rectus abdominis musculocutaneous (TRAM) flap reconstruction is being used more often for the treatment of breast cancer. Mammography is...
Saran, Patricia A., Sondak, Vernon K., Lawrence, Theodore S., Robertson, John M., Chang, Alfred E., Sussman, Jeffrey J.
Background: Local control remains an important issue in the management of large soft tissue sarcomas. Radiation is the main adjuvant to surgery for local therapy of sarcomas, but it requires...
Cytokines as an adjuvant to tumor vaccines: Efficacy of local methods of delivery (1997)
Krinock, Robert A., Chang, Alfred E., Krauss, John C., Kurane, Shuji, Arca, Marjorie T., Aruga, Atsushi
Background: We examined alternative methods of delivering cytokines as an adjunct for priming lymph node (LN) cells draining sites of vaccine inoculation for the purpose of generating immune cells...
Computed tomography in staging of patients with melanoma metastatic to the regional nodes (1997)
Smith, John W., Johnson, Timothy M., Hamlet, K. Renee, Chang, Alfred E., Fader, Darrell J., Sondak, Vernon K., ...
Background: This study addresses the yield and clinical impact of computed tomography (CT) imaging in otherwise asymptomatic patients with stage III melanoma metastatic to the regional nodes.
Yang, Zhi-yong, DeBruyne, Lisa A., Nabel, Gary J., Gordon, David, Cameron, Mark J., Chang, Alfred E., ...
The direct introduction of foreign genes into tumors shows promise as a therapeutic modality to enhance tumor immunogenicity. Hence, melanoma nodules were directly injected with a vector encoding...
Chang, Alfred E., Arca, Marjorie J., Krauss, John C., Cameron, Mark J., Strome, Scott E.
We evaluated the in vivo response to the poorly immunogenic B16-BL6 (BL6) murine melanoma genetically altered to secrete interleukin-2 (IL-2), IL-4, interferon γ (IFNγ) and...
Chang, Alfred E., Sondak, Vernon K., Bishop, D. Keith, Nickoloff, Brian J., Mulligan, Richard C., Mulé, James J.
NON-TECHNICAL ABSTRACT This study involves the use of novel methods to treat patients with advanced cancer by manipulation of their immune system. Based on extensive animal studies, we know that the...
Aruga, Atsushi, Chang, Alfred E., Shu, Suyu
In this study, cytokine release by tumor-draining lymph node cells sensitized in vitro (IVS-TDLN) was examined and correlated with therapeutic efficacy in adoptive immunotherapy. Mice bearing...
Nabel, Elizabeth G., Yang, Zhiyong, Muller, David, Chang, Alfred E., Gao, Xiang, Huang, Leaf, ...
Overview summary Transcatheter delivery of HLA-B7 DNA and cationic liposomes into a segment of a pulmonary artery was safely performed in 1 patient with tumor nodules in the lung. No immunologic or...
Activation of T lymphocytes for the adoptive immunotherapy of cancer (1994)
Shu, Suyu, Chang, Alfred E., Sussman, Jeffrey J., Sondak, Vernon K.
Background: Adoptive immunotherapy of malignancy involves the passive transfer of antitumor-reactive cells into a host in order to mediate tumor regression. Based on animal models, the transfer of...
Rosenberg, Steven A., Lotze, Michael T., Yang, James C., Topalian, Suzanne L., Chang, Alfred E., Schwartzentruber, Douglas J., ...
Background: Treatment using interleukin-2 (IL-2) alone or in conjunction with lymphokine-activated killer (LAK) cells has been shown to mediate disease regression in selected patients with advanced...
Divergent effects of TNF[alpha] in the adoptive immunotherapy of a murine sarcoma (1992)
Wagner, Paul D., Shu, Suyu, Chang, Alfred E.
We have previously described an in vitro sensitization (IVS) procedure which enabled the generation of therapeutic T cells from tumor-bearing mice for adoptive immunotherapy. The procedure involved...
Geiger, J. D., Wagner, Paul D., Shu, S., Chang, Alfred E.
The growth of immunogenic tumours stimulates the generation of tumour-sensitized, but not functional, pre-effector T cells in the draining lymph nodes. These pre-effector cells can mature into...
Activation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy (1991)
Yoshizawa, Hirohisa, Sakai, Keisuke, Chang, Alfred E., Shu, Suyu
Lymph nodes draining progressive tumors contain tumor-sensitized but not functional preeffector T lymphocytes. These cells can acquire antitumor reactivity after stimulation with tumor cells and...
Sakai, Keisuke, Chang, Alfred E., Shu, Suyu
The MCA 102 sarcoma has been defined by a variety of immunologic studies as a tumor lacking intrinsic immunogenicity. Nevertheless, we have recently demonstrated the feasibility of generating...
Repeat hepatic resections for colorectal metastases (1990)
Griffith, Kean D., Sugarbaker, Paul H., Chang, Alfred E.
We identified 106 patients who had undergone complete resection of isolated colorectal hepatic metastases. Nine of these patients subsequently underwent repeat liver resections for isolated hepatic...
Chang, Alfred E., Perry-Lalley, Donna M., Shu, Suyu
Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumorbearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells...
Arora, Alisha, Su, Gang, Mathiowitz, Edith, Reineke, Joshua, Chang, Alfred E., Sabel, Michael S.
Background Sustained intratumoral cytokine release using poly-lactic acid microspheres (PLAMs) can induce a systemic immune response, shifting immunotherapy to the neoadjuvant setting. Methods C57BL6...
Newman, Erika A., Guest, Amy B., Helvie, Mark A., Roubidoux, Marilyn A, Chang, Alfred E., Kleer, Celina G., ...
BACKGROUND The treatment of breast cancer requires a multidisciplinary approach, and patients are often referred to a multidisciplinary cancer clinic. The purpose of the current study was to evaluate...
The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma
Paek, Sandra C., Griffith, Kent A., Johnson, Timothy M., Sondak, Vernon K., Wong, Sandra L., Chang, Alfred E., ...
BACKGROUND. In addition to Breslow depth, the authors previously described how increasing mitotic rate and decreasing age predicted sentinel lymph node (SLN) metastases in patients with melanoma. The...
What is a sentinel node? Re-evaluating the 10% rule for sentinel lymph node biopsy in melanoma
Kroon, Hidde M., Lowe, Lori, Wong, Sandra, Fullen, Doug, Su, Lyndon, Cimmino, Vincent, ...
Introduction Many surgeons use the “10% rule” to define whether a lymph node is a sentinel node (SLN) when staging malignant melanoma. However, this increases the number of SLN removed and the...
Sentinel lymph node biopsy for breast cancer: How many nodes are enough?
Zakaria, Shaheen, Degnim, Amy C., Kleer, Celina G., Diehl, Kathleen A., Cimmino, Vincent M., Chang, Alfred E., ...
Introduction Sentinel lymph node (SLN) biopsy using blue dye and radioisotope often results in the removal of multiple SLNs. We sought to determine whether there is a point where the surgeon can...
Adjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy of cancer
Li, Qiao, Iuchi, Takekazu, Jure-Kunkel, Maria N., Chang, Alfred E.
Administration of anti-4-1BB mAb has been found to be a potent adjuvant when combined with other therapeutic approaches, e.g. chemotherapy, cytokine therapies, anti-OX40 therapy, and peptide or DC...
The Toxicity of Recombinant Human Interleukin-2 in Rats following Intravenous Infusion
Matory, Yvedt L., Chang, Alfred E., Lipford, Edward H., Braziel, Rita, Hyatt, Cornelia L., Rosenberg, Steven A.
Studies of recombinant interleukin-2 (RIL-2) administered by continuous intravenous infusion revealed hepatocellular toxicity and redistribution of lymphoid cells. This finding was different from the...
Yu, Jiyun, Tian, Rong, Xiu, Bingshui, Yan, Jinqi, Jia, Rui, Zhang, Liang, ...
The successful use of tumor-draining lymph nodes (TDLN) as a source of effector cells for cancer immunotherapy depends largely on the immunogenicity of the tumor drained by the lymph nodes as well as...