Alfred Mateczun

The Bacillus anthracischromosome contains four conserved, excision-proficient, putative prophages (2006)

Sozhamannan, Shanmuga, Chute, Michael D, McAfee, Farrell D, Fouts, Derrick E, Akmal, Arya, Galloway, Darrell R, ...

Abstract Background Bacillus anthracis is considered to be a recently emerged clone within the Bacillus cereus sensu lato group. The B. anthracis genome sequence contains four putative lambdoid...

Genetic Immunization Against Anthrax (2006)

Galloway, Darrell, Liner, Adriane, Legutki, Joseph, Mateczun, Alfred, Barnewall, Roy, Estep, James

The objective of this study was to determine whether a DNA prime-protein boost immunization against the Bacillus anthracis protective antigen (PA) and lethal factor (LF) antigens could induce a...

Microarray-based resequencing of multiple Bacillus anthracisisolates (2004)

Zwick, Michael E, Mcafee, Farrell, Cutler, David J, Read, Timothy D, Ravel, Jacques, Bowman, Gregory R, ...

Abstract We used custom-designed resequencing arrays to generate 3.1 Mb of genomic sequence from a panel of 56 Bacillus anthracis strains. Sequence quality was shown to be very high by replication...

Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor Protein

Price, Brian M., Liner, Adriane L., Park, Sukjoon, Leppla, Stephen H., Mateczun, Alfred, Galloway, Darrell R.

The ability of genetic vaccination to protect against a lethal challenge of anthrax toxin was evaluated. BALB/c mice were immunized via gene gun inoculation with eucaryotic expression vector plasmids...

Microarray-based resequencing of multiple Bacillus anthracis isolates

Zwick, Michael E, Mcafee, Farrell, Cutler, David J, Read, Timothy D, Ravel, Jacques, Bowman, Gregory R, ...

Custom-designed resequencing arrays were used to generate 3.1 Mb of genomic sequence from a panel of 56 Bacillus anthracis strains. Sequence quality was shown to be very high by replication and by...

Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor Protein

Price, Brian M., Liner, Adriane L., Park, Sukjoon, Leppla, Stephen H., Mateczun, Alfred, Galloway, Darrell R.

The ability of genetic vaccination to protect against a lethal challenge of anthrax toxin was evaluated. BALB/c mice were immunized via gene gun inoculation with eucaryotic expression vector plasmids...

Microarray-based resequencing of multiple Bacillus anthracis isolates

Zwick, Michael E, Mcafee, Farrell, Cutler, David J, Read, Timothy D, Ravel, Jacques, Bowman, Gregory R, ...

Custom-designed resequencing arrays were used to generate 3.1 Mb of genomic sequence from a panel of 56 Bacillus anthracis strains. Sequence quality was shown to be very high by replication and by...

Human Monoclonal Antibodies against Anthrax Lethal Factor and Protective Antigen Act Independently To Protect against Bacillus anthracis Infection and Enhance Endogenous Immunity to Anthrax▿

Albrecht, Mark T., Li, Han, Williamson, E. Diane, LeButt, Chris S., Flick-Smith, Helen C., Quinn, Conrad P., ...

The unpredictable nature of bioterrorism and the absence of real-time detection systems have highlighted the need for an efficient postexposure therapy for Bacillus anthracis infection. One approach...

Genotyping of Bacillus cereus Strains by Microarray-Based Resequencing

Zwick, Michael E., Kiley, Maureen P., Stewart, Andrew C., Mateczun, Alfred, Read, Timothy D.

The ability to distinguish microbial pathogens from closely related but nonpathogenic strains is key to understanding the population biology of these organisms. In this regard, Bacillus anthracis,...

Molecular Characterization of a Variant of Bacillus anthracis-Specific Phage AP50 with Improved Bacteriolytic Activity▿ †

Sozhamannan, Shanmuga, McKinstry, Michael, Lentz, Shannon M., Jalasvuori, Matti, McAfee, Farrell, Smith, Angela, ...

The genome sequence of a Bacillus anthracis-specific clear plaque mutant phage, AP50c, contains 31 open reading frames spanning 14,398 bp, has two mutations compared to wild-type AP50t, and has a...