Alfred S. L. Cheng

Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer (2008)

Rodriguez, Benjamin A.T., Cheng, Alfred S.L., Yan, Pearlly S., Potter, Dustin, Agosto-Perez, Francisco J., Shapiro, Charles L., ...

Several studies have reported that a high expression ratio of HOXB13 to IL17BR predicts tumor recurrence in node-negative, estrogen receptor (ER) α-positive breast cancer patients treated with...

Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice (2008)

Leung, Wai K., Wu, Kai-chun, Wong, Christine Y. P., Cheng, Alfred S. L., Ching, Arthur K. K., Chan, Anthony W. H., ...

Cyclooxoygenase (COX)-2 overexpression is involved in gastric carcinogenesis. While high-salt intake is a known risk factor for gastric cancer development, we determined the effects of high salt on...

A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-{alpha} (2006)

Li, Lang, Cheng, Alfred S. L., Jin, Victor X., Paik, Henry H., Fan, Meiyun, Li, Xiaoman, ...

Motivation: To detect and select patterns of transcription factor binding sites (TFBSs) which distinguish genes directly regulated by estrogen receptor-α (ERα), we developed an innovative mixture...

Cyclooxygenase-2 Expression in Helicobacter pylori-Associated Premalignant and Malignant Gastric Lesions

Sung, Joseph J. Y., Leung, Wai K., Go, Minnie Y. Y., To, Ka F., Cheng, Alfred S. L., Ng, Enders K. W., ...

Expression of cyclooxygenase-2 (COX-2) in various stages of the Helicobacter pylori-associated gastric carcinogenesis pathway has not been elucidated. We investigated the distribution and intensity...