SNARE protein mimicry by an intracellular bacterium (2008)
Delevoye, Cédric, Nilges, Michael, Dehoux, Pierre, Paumet, Fabienne, Perrinet, Stéphanie, Dautry-Varsat, Alice, ...
Many intracellular pathogens rely on host cell membrane compartments for their survival. The strategies they have developed to subvert intracellular trafficking are often unknown, and SNARE proteins,...
SNARE protein mimicry by an intracellular bacterium (2008)
Delevoye, Cédric, Nilges, Michael, Dehoux, Pierre, Paumet, Fabienne, Perrinet, Stéphanie, Dautry-Varsat, Alice, ...
Many intracellular pathogens rely on host cell membrane compartments for their survival. The strategies they have developed to subvert intracellular trafficking are often unknown, and SNARE proteins,...
Isabelle Derré, Marc Pypaert, Alice Dautry-Varsat, Hervé Agaisse
Chlamydia spp. are intracellular obligate bacterial pathogens that infect a wide range of host cells. Here, we show that C. caviae enters, replicates, and performs a complete developmental cycle in...
Derré, Isabelle, Pypaert, Marc, Dautry-Varsat, Alice, Agaisse, Hervé
Chlamydia spp. are intracellular obligate bacterial pathogens that infect a wide range of host cells. Here, we show that C. caviae enters, replicates, and performs a complete developmental cycle in...
Derré, Isabelle, Pypaert, Marc, Dautry-Varsat, Alice, Agaisse, Hervé
Chlamydia spp. are intracellular obligate bacterial pathogens that infect a wide range of host cells. Here, we show that C. caviae enters, replicates, and performs a complete developmental cycle in...
Sauvonnet, Nathalie, Dujeancourt, Annick, Dautry-Varsat, Alice
Endocytosis is critical for many cellular functions. We show that endocytosis of the common gammac cytokine receptor is clathrin independent by using a dominant-negative mutant of Eps15 or RNA...
Sauvonnet, Nathalie, Dujeancourt, Annick, Dautry-Varsat, Alice
Endocytosis is critical for many cellular functions. We show that endocytosis of the common gammac cytokine receptor is clathrin independent by using a dominant-negative mutant of Eps15 or RNA...
Subtil, Agathe, Delepierre, Muriel, Dautry-Varsat, Alice
High-affinity IL2 receptors consist of three components, the alpha, beta, and gamma chains that are associated in a noncovalent manner. Both the beta and gamma chains belong to the cytokine receptor...
Subtil, Agathe, Delepierre, Muriel, Dautry-Varsat, Alice
High-affinity IL2 receptors consist of three components, the alpha, beta, and gamma chains that are associated in a noncovalent manner. Both the beta and gamma chains belong to the cytokine receptor...
Serpente, Norberto, Hemar, Agnées, Cefal, Daniel, Dautry-Varsat, Alice, Fagard, Remi, Fischer, Siegmund, ...
In vivo infection of human T cell lymphocytes by HIV-1 is mediated by the specific binding of the HIV-1 envelope glycoprotein gp120 to the T cell CD4 receptor. One of the post-infection events...
Rocca, Anna, Lamaze, Christophe, Subtil, Agathe, Dautry-Varsat, Alice
Down-regulation of cell surface growth factor receptors plays a key role in the tight control of cellular responses. Recent reports suggest that the ubiquitin system, in addition to participating in...
Kozyraki, Renata, Fyfe, John, Verroust, Pierre J., Jacobsen, Christian, Dautry-Varsat, Alice, Gburek, Jakub, ...
Cubilin is a 460-kDa protein functioning as an endocytic receptor for intrinsic factor vitamin B12 complex in the intestine and as a receptor for apolipoprotein A1 and albumin reabsorption in the...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
Grange, Marie-Pierre, Blot, Vincent, Delamarre, Lelia, Bouchaert, Isabelle, Rocca, Anna, Dautry-Varsat, Alice, ...
All retrovirus glycoproteins have a cytoplasmic domain that plays several roles in virus replication. We have determined whether and how the cytoplasmic domains of oncoretrovirus glycoproteins...
Role of Bcl-2 Family Members in Caspase-Independent Apoptosis during Chlamydia Infection
Perfettini, Jean-Luc, Reed, John C., Israël, Nicole, Martinou, Jean-Claude, Dautry-Varsat, Alice, Ojcius, David M.
Infection with an obligate intracellular bacterium, the Chlamydia trachomatis lymphogranuloma venereum (LGV/L2) strain or the guinea pig inclusion conjunctivitis serovar of Chlamydia psittaci, leads...
Perfettini, Jean-Luc, Darville, Toni, Dautry-Varsat, Alice, Rank, Roger G., Ojcius, David M.
The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in...
Jutras, Isabelle, Abrami, Laurence, Dautry-Varsat, Alice
Chlamydiae are bacterial pathogens which develop strictly inside the epithelial cells of their hosts. The mechanism used by chlamydiae to enter cells is not well characterized; however, it is thought...
Coumailleau, Franck, Das, Vincent, Alcover, Andres, Raposo, Graça, Vandormael-Pournin, Sandrine, Le Bras, Stéphanie, ...
Endocytosed membrane components are recycled to the cell surface either directly from early/sorting endosomes or after going through the endocytic recycling compartment (ERC). Studying recycling...
Rocca, Anna, Lamaze, Christophe, Subtil, Agathe, Dautry-Varsat, Alice
Down-regulation of cell surface growth factor receptors plays a key role in the tight control of cellular responses. Recent reports suggest that the ubiquitin system, in addition to participating in...
Kozyraki, Renata, Fyfe, John, Verroust, Pierre J., Jacobsen, Christian, Dautry-Varsat, Alice, Gburek, Jakub, ...
Cubilin is a 460-kDa protein functioning as an endocytic receptor for intrinsic factor vitamin B12 complex in the intestine and as a receptor for apolipoprotein A1 and albumin reabsorption in the...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
Grange, Marie-Pierre, Blot, Vincent, Delamarre, Lelia, Bouchaert, Isabelle, Rocca, Anna, Dautry-Varsat, Alice, ...
All retrovirus glycoproteins have a cytoplasmic domain that plays several roles in virus replication. We have determined whether and how the cytoplasmic domains of oncoretrovirus glycoproteins...
Role of Bcl-2 Family Members in Caspase-Independent Apoptosis during Chlamydia Infection
Perfettini, Jean-Luc, Reed, John C., Israël, Nicole, Martinou, Jean-Claude, Dautry-Varsat, Alice, Ojcius, David M.
Infection with an obligate intracellular bacterium, the Chlamydia trachomatis lymphogranuloma venereum (LGV/L2) strain or the guinea pig inclusion conjunctivitis serovar of Chlamydia psittaci, leads...
Perfettini, Jean-Luc, Darville, Toni, Dautry-Varsat, Alice, Rank, Roger G., Ojcius, David M.
The effect of gamma interferon (IFN-γ) on apoptosis due to infection by Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) was studied in epithelial cells in culture and in...
Jutras, Isabelle, Abrami, Laurence, Dautry-Varsat, Alice
Chlamydiae are bacterial pathogens which develop strictly inside the epithelial cells of their hosts. The mechanism used by chlamydiae to enter cells is not well characterized; however, it is thought...
Coumailleau, Franck, Das, Vincent, Alcover, Andres, Raposo, Graça, Vandormael-Pournin, Sandrine, Le Bras, Stéphanie, ...
Endocytosed membrane components are recycled to the cell surface either directly from early/sorting endosomes or after going through the endocytic recycling compartment (ERC). Studying recycling...
RNAi Screen in Drosophila Cells Reveals the Involvement of the Tom Complex in Chlamydia Infection
Derré, Isabelle, Pypaert, Marc, Dautry-Varsat, Alice, Agaisse, Hervé
Chlamydia spp. are intracellular obligate bacterial pathogens that infect a wide range of host cells. Here, we show that C. caviae enters, replicates, and performs a complete developmental cycle in...
SNARE Protein Mimicry by an Intracellular Bacterium
Delevoye, Cédric, Nilges, Michael, Dehoux, Pierre, Paumet, Fabienne, Perrinet, Stéphanie, Dautry-Varsat, Alice, ...
Many intracellular pathogens rely on host cell membrane compartments for their survival. The strategies they have developed to subvert intracellular trafficking are often unknown, and SNARE proteins,...
Cortactin and dynamin are required for the clathrin-independent endocytosis of γc cytokine receptor
Sauvonnet, Nathalie, Dujeancourt, Annick, Dautry-Varsat, Alice
Endocytosis is critical for many cellular functions. We show that endocytosis of the common γc cytokine receptor is clathrin independent by using a dominant-negative mutant of Eps15 or RNA...
Chiu, Ya-Hui, Jayawardena, Jayanthi, Weiss, Angela, Lee, Daniel, Park, Se-Ho, Dautry-Varsat, Alice, ...
Although recent studies have indicated that the major histocompatibility complex–like, β2-microglobulin–associated CD1 molecules might function to present a novel chemical class of antigens,...
AP-2/Eps15 Interaction Is Required for Receptor-mediated Endocytosis
Benmerah, Alexandre, Lamaze, Christophe, Bègue, Bernadette, Schmid, Sandra L., Dautry-Varsat, Alice, Cerf-Bensussan, Nadine
We have previously shown that the protein Eps15 is constitutively associated with the plasma membrane adaptor complex, AP-2, suggesting its possible role in endocytosis. To explore the role of Eps15...
Subtil, Agathe, Delepierre, Muriel, Dautry-Varsat, Alice
High-affinity IL2 receptors consist of three components, the α, β, and γ chains that are associated in a noncovalent manner. Both the β and γ chains belong to the cytokine receptor superfamily....
Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2
Grassart, Alexandre, Dujeancourt, Annick, Lazarow, Paul B, Dautry-Varsat, Alice, Sauvonnet, Nathalie
There are several endocytic pathways, which are either dependent on or independent of clathrin. This study focuses on a poorly characterized mechanism—clathrin- and caveolae-independent...