Alina Patke, Alexander Tarakhovsky, Alina Patke, Ingrid Mecklenbräuker, Hediye Erdjument-bromage, Paul Tempst, ...
B cell antigen receptor; BAFF, B cell–activating factor of the TNF family; BAFF-R, BAFF receptor; eIF4E, eukaryotic translation initiation factor 4E; GO, gene ontology; GSK-3, glycogen synthase...
Analysis of signaling mechanisms essential to mature B cell viability (2007)
Die Langlebigkeit reifer periphärer B Zellen ist abhängig von mindestens zwei Überlebenssignalen, einem tonischen Signal, welches vom B Zellrezeptor ausgeht und dem Zytokin B Zell aktivierender...
Analysis of signaling mechanisms essential to mature B cell viability (2007)
Die Langlebigkeit reifer periphärer B Zellen ist abhängig von mindestens zwei Überlebenssignalen, einem tonischen Signal, welches vom B Zellrezeptor ausgeht und dem Zytokin B Zell aktivierender...
Krappmann, Daniel, Patke, Alina, Heissmeyer, Vigo, Scheidereit, Claus
Antigen receptor signaling is known to activate NF-κB in lymphocytes. While T-cell-receptor-induced NF-κB activation critically depends on novel protein kinase C θ (PKCθ), the role of novel PKCs...
Krappmann, Daniel, Patke, Alina, Heissmeyer, Vigo, Scheidereit, Claus
Antigen receptor signaling is known to activate NF-κB in lymphocytes. While T-cell-receptor-induced NF-κB activation critically depends on novel protein kinase C θ (PKCθ), the role of novel PKCs...
BAFF controls B cell metabolic fitness through a PKCβ- and Akt-dependent mechanism
Patke, Alina, Mecklenbräuker, Ingrid, Erdjument-Bromage, Hediye, Tempst, Paul, Tarakhovsky, Alexander
B cell life depends critically on the cytokine B cell–activating factor of the tumor necrosis factor family (BAFF). Lack of BAFF signaling leads to B cell death and immunodeficiency. Excessive BAFF...
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells
Otipoby, Kevin L., Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Patke, Alina, Gareus, Ralph, Pasparakis, Manolis, ...
B cell activating factor (BAFF) signals through BAFF-R to promote mature B cell survival. Recent analyses of BAFF-induced signaling revealed direct association between augmented B cell metabolic...