Alison M. Condliffe

Signal (2005)

Alison M. Condliffe, Keith Davidson, Karen E. Anderson, Chris D. Ellson, Tom Crabbe, Bart Vanhaesebroeck, ...

doi:10.1182/blood-2005-03-0944 Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells (2000)

Condliffe, Alison M, Cadwallader, Karen A, Walker, Trevor R, Rintoul, Robert C, Cowburn, Andrew S, Chilvers, Edwin R

Abstract Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events...

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells

Condliffe, Alison M, Cadwallader, Karen A, Walker, Trevor R, Rintoul, Robert C, Cowburn, Andrew S, Chilvers, Edwin R

Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a...

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells

Condliffe, Alison M, Cadwallader, Karen A, Walker, Trevor R, Rintoul, Robert C, Cowburn, Andrew S, Chilvers, Edwin R

Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a...

Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells

Condliffe, Alison M, Cadwallader, Karen A, Walker, Trevor R, Rintoul, Robert C, Cowburn, Andrew S, Chilvers, Edwin R

Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a...

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

Walmsley, Sarah R., Print, Cristin, Farahi, Neda, Peyssonnaux, Carole, Johnson, Randall S., Cramer, Thorsten, ...

Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These inflammatory sites are characterized by...

Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake

Willcocks, Lisa C., Lyons, Paul A., Clatworthy, Menna R., Robinson, James I., Yang, Wanling, Newland, Stephen A., ...

Copy number (CN) variation (CNV) has been shown to be common in regions of the genome coding for immune-related genes, and thus impacts upon polygenic autoimmunity. Low CN of FCGR3B has recently been...