A simple relationship between viral load and survival time in HIV-1 infection
Arnaout, Ramy A., Lloyd, Alun L., O’Brien, Thomas R., Goedert, James J., Leonard, John M., Nowak, Martin A.
Despite important recent insights into the short-term dynamics of HIV-1 infection, our understanding of the long-term pathogenesis of AIDS remains unclear. Using an approach that places rapid...
Jeffery, Katie J. M., Usuku, Koichiro, Hall, Sarah E., Matsumoto, Wataru, Taylor, Graham P., Procter, Jeanette, ...
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is...
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
Chun, Tae-Wook, Stuyver, Lieven, Mizell, Stephanie B., Ehler, Linda A., Mican, Jo Ann M., Baseler, Michael, ...
Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to...
A simple relationship between viral load and survival time in HIV-1 infection
Arnaout, Ramy A., Lloyd, Alun L., O’Brien, Thomas R., Goedert, James J., Leonard, John M., Nowak, Martin A.
Despite important recent insights into the short-term dynamics of HIV-1 infection, our understanding of the long-term pathogenesis of AIDS remains unclear. Using an approach that places rapid...
Jeffery, Katie J. M., Usuku, Koichiro, Hall, Sarah E., Matsumoto, Wataru, Taylor, Graham P., Procter, Jeanette, ...
The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is...
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
Chun, Tae-Wook, Stuyver, Lieven, Mizell, Stephanie B., Ehler, Linda A., Mican, Jo Ann M., Baseler, Michael, ...
Although highly active antiretroviral therapy (HAART) in the form of triple combinations of drugs including protease inhibitors can reduce the plasma viral load of some HIV-1-infected individuals to...
Immune responses and the emergence of drug-resistant virus strains in vivo.
Wodarz, Dominik, Lloyd, Alun L
The treatment of viral infections using antiviral drugs has had a significant public health benefit in the setting of human immunodeficiency virus (HIV) infection, and newly developed drugs offer...
Stochasticity and heterogeneity in host–vector models
Lloyd, Alun L, Zhang, Ji, Root, A.Morgan
Demographic stochasticity and heterogeneity in transmission of infection can affect the dynamics of host–vector disease systems in important ways. We discuss the use of analytic techniques to...
A Killer–Rescue system for self-limiting gene drive of anti-pathogen constructs
Gould, Fred, Huang, Yunxin, Legros, Mathieu, Lloyd, Alun L
A number of genetic mechanisms have been suggested for driving anti-pathogen genes into natural populations. Each of these mechanisms requires complex genetic engineering, and most are theoretically...
Magori, Krisztian, Legros, Mathieu, Puente, Molly E., Focks, Dana A., Scott, Thomas W., Lloyd, Alun L., ...
Dengue is a viral disease that affects approximately 50 million people annually, and is estimated to result in 12,500 fatalities. Dengue viruses are vectored by mosquitoes, predominantly by the...