Zhang, Haihong, Mizumachi, Takatsugu, Carcel-Trullols, Jaime, Li, Liwen, Naito, Akihiro, Spencer, Horace J., ...
Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA...
Browne, Jacinta, Watson, Amanda J., Hoskins, Peter, Elliott, Alex
Tissue harmonic imaging (THI) has been reported to improve contrast resolution, tissue differentiation and overall image quality in clinical examinations. However, a study carried out previously by...
Margison, Geoffrey P., Heighway, Jim, Pearson, Steven, McGown, Gail, Thorncroft, Mary R., Watson, Amanda J., ...
The repair of specific types of DNA alkylation damage by O6-alkylguanine-DNA alkyltransferase (MGMT) is a major mechanism of resistance to the carcinogenic and chemotherapeutic effects of certain...
Margison, Geoffrey P., Heighway, Jim, Pearson, Steven, McGown, Gail, Thorncroft, Mary R., Watson, Amanda J., ...
The repair of specific types of DNA alkylation damage by O6-alkylguanine-DNA alkyltransferase (MGMT) is a major mechanism of resistance to the carcinogenic and chemotherapeutic effects of certain...
Rafferty, Joseph A., Elder, Rhoderick H., Watson, Amanda J., Cawkwell, Lynn, Potter, Philip M., Margison, Geoffrey P.
The cDNA encoding Chinese hamster O6-alkylguanine-DNA-alkyltransferase (ATase) has been isolated from a library prepared from RNA isolated from V79 lung flbroblasts which had an upregulated level of...
Warwick-Davies, Jan, Watson, Amanda J., Griffin, George E., Krishna, Sanjeev, Shattock, Robin J.
Mycobacterium tuberculosis alone induces small, donor-variable amounts of tumor necrosis factor alpha (TNF-α) from primary human monocytes in vitro. However, TNF-α release is increased 5- to...
Elder, Rhoderick H., Jansen, Jacob G., Weeks, Robert J., Willington, Mark A., Deans, Bryan, Watson, Amanda J., ...
Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse...
A novel DNA damage recognition protein in Schizosaccharomyces pombe
Pearson, Steven J., Wharton, Stephen, Watson, Amanda J., Begum, Ghazala, Butt, Amna, Glynn, Nicola, ...
Toxic and mutagenic O6-alkylguanine adducts in DNA are repaired by O6-alkylguanine-DNA alkyltransferases (MGMT) by transfer of the alkyl group to a cysteine residue in the active site. Comparisons in...
Warwick-Davies, Jan, Watson, Amanda J., Griffin, George E., Krishna, Sanjeev, Shattock, Robin J.
Mycobacterium tuberculosis alone induces small, donor-variable amounts of tumor necrosis factor alpha (TNF-α) from primary human monocytes in vitro. However, TNF-α release is increased 5- to...
Elder, Rhoderick H., Jansen, Jacob G., Weeks, Robert J., Willington, Mark A., Deans, Bryan, Watson, Amanda J., ...
Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse...
A novel DNA damage recognition protein in Schizosaccharomyces pombe
Pearson, Steven J., Wharton, Stephen, Watson, Amanda J., Begum, Ghazala, Butt, Amna, Glynn, Nicola, ...
Toxic and mutagenic O6-alkylguanine adducts in DNA are repaired by O6-alkylguanine-DNA alkyltransferases (MGMT) by transfer of the alkyl group to a cysteine residue in the active site. Comparisons in...