Amy E. Kiernan, Jingxia Xu, Thomas Gridley
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their...
Amy E. Kiernan, Jingxia Xu, Thomas Gridley
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, the sensory cells, and their associated...
Tsai, Hsun, Hardisty, Rachel E., Rhodes, Charlotte, Kiernan, Amy E., Roby, Phil, Tymowska-Lalanne, Zuzanna, ...
The Notch signalling pathway has recently been implicated in the development and patterning of the sensory epithelium in the cochlea, the organ of Corti. As part of an ongoing large-scale mutagenesis...
The Notch ligand Jagged1 is required for inner ear sensory development
Kiernan, Amy E., Ahituv, Nadav, Fuchs, Helmut, Balling, Rudi, Avraham, Karen B., Steel, Karen P., ...
Within the mammalian inner ear there are six separate sensory regions that subserve the functions of hearing and balance, although how these sensory regions become specified remains unknown. Each...
Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?
Brigande, John V., Kiernan, Amy E., Gao, Xiaoying, Iten, Laurie E., Fekete, Donna M.
The membranous labyrinth of the inner ear establishes a precise geometrical topology so that it may subserve the functions of hearing and balance. How this geometry arises from a simple ectodermal...
The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, Amy E, Xu, Jingxia, Gridley, Thomas
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their...
The Notch ligand Jagged1 is required for inner ear sensory development
Kiernan, Amy E., Ahituv, Nadav, Fuchs, Helmut, Balling, Rudi, Avraham, Karen B., Steel, Karen P., ...
Within the mammalian inner ear there are six separate sensory regions that subserve the functions of hearing and balance, although how these sensory regions become specified remains unknown. Each...
Molecular genetics of pattern formation in the inner ear: Do compartment boundaries play a role?
Brigande, John V., Kiernan, Amy E., Gao, Xiaoying, Iten, Laurie E., Fekete, Donna M.
The membranous labyrinth of the inner ear establishes a precise geometrical topology so that it may subserve the functions of hearing and balance. How this geometry arises from a simple ectodermal...
The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, Amy E, Xu, Jingxia, Gridley, Thomas
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their...
Genetic Background Modifies Inner Ear and Eye Phenotypes of Jag1 Heterozygous Mice
Kiernan, Amy E., Li, Renhua, Hawes, Norman L., Churchill, Gary A., Gridley, Thomas
Mice heterozygous for missense mutations of the Notch ligand Jagged1 (Jag1) exhibit head-shaking behavior indicative of an inner ear vestibular defect. In contrast, mice heterozygous for a targeted...