Health-Related Phenotypes and Longevity in Danish Twins (2009)
Kulminski, Alexander M., Arbeev, Konstantin G., Culminskaya, Irina V., Ukraintseva, Svetlana V., Christensen, Kaare, Yashin, Anatoli I.
Aging studies can be facilitated by refocusing from longevity phenotypes to their proxies (intermediate phenotypes). Robust selection of the intermediate phenotypes requires data on such phenotypes...
Abstract Correlated Frailty Models in the Analysis of Dependent Failure Times (2008)
The multivariate survival distributions are used for description of dependent failure times (life spans)
Kulminski, Alexander, Ukraintseva, Svetlana V., Arbeev, Konstantin G., Manton, Kenneth G., Oshima, Junko, Martin, George M., ...
Background: early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with disability. Objective: to analyse sex-specific associations of APOE genotypes...
*Address for correspondence (2007)
Karen Andersen-ranberg, Qihua Tan, Qihua Tan, Anatoli I. Yashin, Anatoli I. Yashin, Else M. Bladbjerg, ...
© Copyright is held by the authors.
Two proofs of a recent formula by Griffith Feeney (2006)
Jutta Gampe, Anatoli I. Yashin
This reflexion provides two mathematical proofs for Equation (1) in Feeney (2006), published in this journal as 14-2.
The heritability of CHD mortality in Danish twins after controlling for smoking and BMI (2005)
Wienke, Andreas, Herskind, Anne M., Christensen, Kaare, Skytthe, Axel, Yashin, Anatoli I.
Cause-specific mortality data on Danish monozygotic and dizygotic twins are used to analyze heritability estimates of susceptibility to coronary heart disease (CHD) after controlling for smoking and...
Estimating haplotype relative risks on human survival in population-based association studies (2005)
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Zhao, Jing H., Yashin, Anatoli I., Vaupel, James W., ...
Association-based linkage disequilibrium (LD) mapping is an increasingly important tool for localizing genes that show potential influence on human aging and longevity. As haplotypes contain more LD...
Mathematical models for human cancer incidence rates (2005)
Arbeev, Konstantin G., Ukraintseva, Svetlana V., Arbeeva, Liubov S., Yashin, Anatoli I.
The overall cancer incidence rate declines at old ages. Possible causes of this decline include the effects of cross-sectional data which transform cohort dynamics into age pattern, population...
Decline in human cancer incidence rates at old ages: age-period-cohort considerations (2005)
Arbeev, Konstantin G., Ukraintseva, Svetlana V., Arbeeva, Liubov S., Yashin, Anatoli I.
Analysis of age-specific trajectories of cancer incidence rates for all sites combined (data source: International Agency for Research on Cancer) reveals a leveling-off and decline of the rates at...
Economic progress as cancer risk factor. I: Puzzling facts of cancer epidemiology (2005)
Ukraintseva, Svetlana V., Yashin, Anatoli I.
The increase in cancer burden in developed countries refers to three major causes: population aging, an increase in the cancer incidence rate, and an improvement in the survival of cancer patients....
Ukraintseva, Svetlana V., Yashin, Anatoli I.
Analysis of data on cancer incidence rates in different countries at different time periods revealed positive association between overall cancer risk and economic progress. Typical explanations of...
Season of birth influences life span of Mediterranean fruit flies, rats and mice (2005)
Semenchenko, Anna V., Doblhammer, Gabriele, Anisimov, Vladimir N., Carey, James R., Yashin, Anatoli I.
Mathematical Models for Human Cancer Incidence Rates (2005)
Konstantin G. Arbeev, Lyubov S. Arbeeva, Svetlana Ukraintseva, Anatoli I. Yashin
The overall cancer incidence rate declines at old ages. Possible causes of this decline include the effects of cross-sectional data which transform cohort dynamics into age pattern, population...
Decline in Human Cancer Incidence Rates at Old Ages: Age-Period-Cohort Considerations (2005)
Konstantin G. Arbeev, Lyubov S. Arbeeva, Svetlana Ukraintseva, Anatoli I. Yashin
Analysis of age-specific trajectories of cancer incidence rates for all sites combined (data source: International Agency for Research on Cancer) reveals a leveling-off and decline of the rates at...
Larsen, Ulla., Yan, Sharon., Yashin, Anatoli I.
Population Review - Volume 42, Number 1-2, 2003
Multidisciplinary approaches in genetic studies of human aging and longevity (2004)
Tan, Qihua, Yashin, Anatoli I., Christensen, Kaare, Jeune, Bernard, De Benedictis, Giovanna, Kruse, Torben A., ...
The amount of research on human aging and longevity has been growing rapidly in recent years. Multidisciplinary approaches, which integrate classic population genetics methods with the principles of...
Assessing genetic association with human survival at multi-allelic loci (2004)
Tan, Qihua, De Benedictis, Giovanna, Yashin, Anatoli I., Bathum, Lise, Christiansen, Lene, Dahlgaard, Jesper, ...
Genetic variation plays an important role in natural selection and population evolution. However, it also presents geneticists interested in aging research with problems in data analysis because of...
Semenchenko, Anna V., Khazaeli, Aziz A., Curtsinger, James W., Yashin, Anatoli I.
An approach towards analyzing survivorship data is proposed for the study of changes in stress resistance with age in the population of Drosophila melanogaster. This is based on the model of...
Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice? (2004)
Semenchenko, Anna V., Anisimov, Vladimir N., Yashin, Anatoli I.
The purpose of this study is to investigate possible influences of different stressors (saline injections, light deprivation and constant light regimen) and geroprotectors (Epitalon and melatonin) on...
Romanyukha, Alexei A., Carey, James R., Karkach, Arseniy S., Yashin, Anatoli I.
Understanding the factors that determine the allocation and utilization of organism resources may provide an insight into the mechanisms of adaptation, ageing and reproduction. Resource allocation,...
Baturin, Dmitri A., Alimova, Irina N., Popovich, Irina G., Zabezhinski, Mark A., Semenchenko, Anna V., Yashin, Anatoli I., ...
Twenty five female HER-2/neu transgenic mice (FVB/N), aged 2 months, were surgically deprived of lighting; 30 intact transgenic mice, kept under standard conditions, were in control. Light...
Anisimov, Vladimir N., Baturin, Dmitri A., Popovich, Irina G., Zabezhinski, Mark A., Manton, Kenneth G., Semenchenko, Anna V., ...
The effect of constant illumination on the development of spontaneous tumors in female CBA mice was investigated. Fifty female CBA mice starting from the age of 2 months were kept under standard...
Body weight is not always a good predictor of longevity in mice (2004)
Anisimov, Vladimir N., Arbeev, Konstantin G., Popovich, Irina G., Zabezhinski, Mark A., Rosenfeld, Svetlana V., Piskunova, Tatiana S., ...
There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1) during the first half of life are predictors of longer life in mice. However, contradictions in...
Wienke, Andreas, Holm, Niels V., Christensen, Kaare, Skytthe, Axel, Vaupel, James W., Yashin, Anatoli I.
The genetic influence on susceptibility to diseases of the respiratory system and all-cause mortality was studied using data for identical (MZ)and fraternal (DZ) twins. Data from the Danish Twin...
Anisimov, Vladimir N., Alimova, Irina N., Baturin, Dmitri A., Popovich, Irina G., Zabezhinski, Mark A., Manton, Kenneth G., ...
Anisimov, Vladimir N., Alimova, Irina N., Baturin, Dmitri A., Popovich, Irina G., Zabezhinski, Mark A., Rosenfeld, Svetlana V., ...
Anisimov, Vladimir N., Khavinson, Vladimir K., Popovich, Irina G., Zabezhinski, Mark A., Alimova, Irina N., Rosenfeld, Svetlana V., ...
Anisimov, Vladimir N., Popovich, Irina G., Alimova, Irina N., Zabezhinski, Mark A., Semenchenko, Anna V., Yashin, Anatoli I.
Insulin and longevity: antidiabetic biguanides as geroprotectors (2003)
Anisimov, Vladimir N., Semenchenko, Anna V., Yashin, Anatoli I.
A simulation study of different correlated frailty models and estimation strategies (2003)
Wienke, Andreas, Arbeev, Konstantin, Locatelli, Isabella, Yashin, Anatoli I.
Frailty models are becoming more and more popular in the area of multivariate survival analysis. In particular, shared frailty models are often used despite their limitations. To overcome the...
Unobserved heterogeneity in a model with cure fraction applied to breast cancer (2003)
Wienke, Andreas, Lichtenstein, Paul, Yashin, Anatoli I.
We suggest a cure-mixture model to analyze bivariate time-to-event data, as motivated by the paper of Chatterjee and Shih (2001, Biometrics 57, 779 - 786), but with a simpler estimation procedure and...
Stochastic process model of mortality and aging: application to longitudinal data (2003)
Akushevich, Igor, Akushevich, Lucy, Manton, Kenneth G., Yashin, Anatoli I.
Popovich, Irina G., Voitenkov, Boris O., Anisimov, Vladimir N., Ivanov, Vadim T., Mikhaleva, Inessa I., Zabezhinski, Mark A., ...
Rose, Guiseppina, Dato, Serena, Altomare, Katia, Bellizzi, Dina, Garasto, Sabrina, Greco, Valentina, ...
The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model...
Tan, Qihua, Bathum, Lise, Christiansen, Lene, De Benedictis, Giovanna, Dahlgaard, Jesper, Frizner, N, ...
In this paper, we apply logistic regression models to measure genetic association with human survival for highly polymorphic and pleiotropic genes. By modelling genotype frequency as a function of...
Tan,Qihua, Bellizzi,Dina, Rose,Guiseppina, Garasto,S., Franceschi,Claudio, Kruse,Torben, ...
A new method based on the recently developed relative risk approach is introduced, and applied to data from Italian centenarian study (965 subjects aged from 13 to 109 years old) for investigating...
Bonafe,Maximilliano, Barbi,Cristina, Olivieri,Fabiola, Yashin,Anatoli I., Andreev,Kirill F., Vaupel,James W., ...
A centenarian-only approach for assessing gene-gene interaction in human longevity (2002)
Tan,Qihua, De Benedictis,Giovanna, Ukraintseva,Svetlana V., Franceschi,Claudio, Vaupel,James W., Yashin,Anatoli I.
Wienke,Andreas, Christensen,Kaare, Skytthe,Axel, Yashin,Anatoli I.
A mixture model in multivariate survival analysis is presented, whereby heterogeneity among subjects creates divergent paths for the individual's risk of experiencing an event (i.e., disease), as...
The influence of smoking and BMI on heritability in susceptibility to coronary heart disease (2002)
Wienke,Andreas, Herskind,A. M., Christensen,Kaare, Skytthe,Axel, Yashin,Anatoli I.
Cause-specific mortality data on Danish monozygotic (MZ) and dizygotic (DZ) twins are used to analyze the influence of smoking and body mass index (BMI) on heritability estimates of susceptibility to...
A case-only approach for assessing gene by sex interaction in human longevity (2002)
Tan,Qihua, Yashin,Anatoli I., Bladbjerg,Else M., De Maat,Moniek, Andersen-Ranberg,Karen, Jeune,Bernard, ...
As one aspect of the complex feature of longevity, gene by sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing...
Zdravkovic,Slobodan, Wienke,Andreas, Pedersen,Nancy L., Marenberg,Marjorie E., Yashin,Anatoli I., De Faire,Ulf
The aim of the present study was to evaluate and distinguish between environmental and genetic effects for death from coronary heart disease (CHD) as well as to determine whether the importance of...
Yashin,Anatoli I., Cypser,James R., Johnson,Thomas E., Mikhalski,Anatoli I., Boiko,Serge I., Novoseltsev,Vassili N.
In this paper we analyze survival data of populations of sterilized nematodes, Caenorhabditis elegans, exposed to heat shocks of different duration at the beginning of their adult lives. There are...
Genetic analysis of cause of death in a mixture model of bivariate lifetime data (2002)
Wienke,Andreas, Christensen,Kaare, Skytthe,Axel, Yashin,Anatoli I.
A mixture model in multivariate survival analysis is presented, whereby heterogeneity among subjects creates divergent paths for the individual's risk of experiencing an event (i.e., disease), as...
Male/female ratio in centenarians: a possible role played by population genetic structure (2002)
Passarino,Guiseppe, Calignano,Cinzia, Vallone,Adriana, Franceschi,Claudio, Jeune,Bernard, Robine,Jean-M., ...
A model of accelerated aging induced by 5-bromodeoxyuridine (2002)
Butov,Alexander A., Volkov,Maxim, Anisimov,Vladimir N., Sehl,Mary, Yashin,Anatoli I.
A case-only approach for assessing gene by sex interaction in human longevity (2002)
Tan, Qihua, Yashin, Anatoli I., Bladbjerg, Else M., De Maat, Moniek, Andersen-Ranberg, Karen, Jeune, Bernard, ...
As one aspect of the complex feature of longevity, gene by sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing...
A centenarian-only approach for assessing gene-gene interaction in human longevity (2002)
Tan, Qihua, De Benedictis, Giovanna, Ukraintseva, Svetlana V., Franceschi, Claudio, Vaupel, James W., Yashin, Anatoli I.
Tan, Qihua, Bellizzi, Dina, Rose, Guiseppina, Garasto, S., Franceschi, Claudio, Kruse, Torben, ...
A new method based on the recently developed relative risk approach is introduced, and applied to data from Italian centenarian study (965 subjects aged from 13 to 109 years old) for investigating...
Zdravkovic, Slobodan, Wienke, Andreas, Pedersen, Nancy L., Marenberg, Marjorie E., Yashin, Anatoli I., De Faire, Ulf
The aim of the present study was to evaluate and distinguish between environmental and genetic effects for death from coronary heart disease (CHD) as well as to determine whether the importance of...
Yashin, Anatoli I., Cypser, James R., Johnson, Thomas E., Mikhalski, Anatoli I., Boiko, Serge I., Novoseltsev, Vassili N.
In this paper we analyze survival data of populations of sterilized nematodes, Caenorhabditis elegans, exposed to heat shocks of different duration at the beginning of their adult lives. There are...
Genetic analysis of cause of death in a mixture model of bivariate lifetime data (2002)
Wienke, Andreas, Christensen, Kaare, Skytthe, Axel, Yashin, Anatoli I.
A mixture model in multivariate survival analysis is presented, whereby heterogeneity among subjects creates divergent paths for the individual's risk of experiencing an event (i.e., disease), as...
Male/female ratio in centenarians: a possible role played by population genetic structure (2002)
Passarino, Guiseppe, Calignano, Cinzia, Vallone, Adriana, Franceschi, Claudio, Jeune, Bernard, Robine, Jean-M., ...
A model of accelerated aging induced by 5-bromodeoxyuridine (2002)
Butov, Alexander A., Volkov, Maxim, Anisimov, Vladimir N., Sehl, Mary, Yashin, Anatoli I.
Bonafe, Maximilliano, Barbi, Cristina, Olivieri, Fabiola, Yashin, Anatoli I., Andreev, Kirill F., Vaupel, James W., ...
The influence of smoking and BMI on heritability in susceptibility to coronary heart disease (2002)
Wienke, Andreas, Herskind, A. M., Christensen, Kaare, Skytthe, Axel, Yashin, Anatoli I.
Cause-specific mortality data on Danish monozygotic (MZ) and dizygotic (DZ) twins are used to analyze the influence of smoking and body mass index (BMI) on heritability estimates of susceptibility to...
Wienke, Andreas, Christensen, Kaare, Skytthe, Axel, Yashin, Anatoli I.
A mixture model in multivariate survival analysis is presented, whereby heterogeneity among subjects creates divergent paths for the individual's risk of experiencing an event (i.e., disease), as...
Biodemographic trajectories of longevity (1998)
James W. Vaupel, James R. Carey, Kaare Christensen, Thomas E. Johnson, Anatoli I. Yashin, Niels V. Holm, ...
Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival is...
Manton, Kenneth G., Yashin, Anatoli I.
Stochastically changing covariates may influence survival. They may be observed, unobserved or partly observed. We review the properties of hazard models explicitly representing the effects of...
Two proofs of a recent formula by Griffith Feeney
Jutta Gampe, Anatoli I. Yashin
This reflexion provides two mathematical proofs for Equation (1) in Feeney (2006), published in this journal as 14-2.
Individual Aging and Cancer Risk: How are They Related?
Svetlana Ukraintseva, Anatoli I. Yashin
When individuals get older, the risk of many chronic diseases increases. This increase is in agreement with common theories of aging, such as mutation accumulation, wear and tear, antagonistic...
Mathematical Models for Human Cancer Incidence Rates
Konstantin G. Arbeev, Svetlana Ukraintseva, Lyubov S. Arbeeva, Anatoli I. Yashin
The overall cancer incidence rate declines at old ages. Possible causes of this decline include the effects of cross-sectional data which transform cohort dynamics into age pattern, population...
Decline in Human Cancer Incidence Rates at Old Ages: Age-Period-Cohort Considerations
Konstantin G. Arbeev, Svetlana Ukraintseva, Lyubov S. Arbeeva, Anatoli I. Yashin
Analysis of age-specific trajectories of cancer incidence rates for all sites combined (data source: International Agency for Research on Cancer) reveals a leveling-off and decline of the rates at...
Vassili N. Novoseltsev, Anatoli I. Michalski, Janna A. Novoseltseva, Anatoli I. Yashin, James R. Carey, Thomas W. Scott
In the paper basic epidemiological indicators, produced by an aging population of vectors, are calculated. In the study we follow two lines: calculations for demographically structured population and...
Genetic analysis of cause of death in a bivariate lifetime model with dependent competing risks
Andreas Wienke, Kaare Christensen, Axel Skytthe, Anatoli I. Yashin
A mixture model in multivariate survival analysis is presented, whereby heterogeneity among subjects creates divergent paths for the individual's risk of experiencing an event (i.e., disease), as...
A simulation study of different correlated frailty models and estimation strategies
Andreas Wienke, Konstantin G. Arbeev, Isabella Locatelli, Anatoli I. Yashin
Frailty models are becoming more and more popular in the area of multivariate survival analysis. In particular, shared frailty models are often used despite their limitations. To overcome the...
Economic progress as cancer risk factor. I: Puzzling facts of cancer epidemiology
Svetlana V. Ukraintseva, Anatoli I. Yashin
The increase in cancer burden in developed countries refers to three major causes: population aging, an increase in the cancer incidence rate, and an improvement in the survival of cancer patients....
Cancer rates over age, time, and place: insights from stochastic models of heterogeneous populations
James W. Vaupel, Anatoli I. Yashin
Individuals at the same age in the same population differ along numerous risk factors that affect their chances of various causes of death. The frail and susceptible tend to die first. This...
A case-only approach for assessing gene-sex interaction in human longevity
Qihua Tan, Anatoli I. Yashin, Else M. Bladbjerg, Moniek De Maat, Karen Andersen-Ranberg, Bernard Jeune, ...
As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing...
The influence of smoking and BMI on heritability in susceptibility to coronary heart disease
Andreas Wienke, Anne M. Herskind, Kaare Christensen, Axel Skytthe, Anatoli I. Yashin
Cause-specific mortality data on Danish monozygotic (MZ) and dizygotic (DZ) twins are used to analyze the influence of smoking and body mass index (BMI) on heritability estimates of susceptibility to...
Unobserved heterogeneity in a model with cure fraction applied to breast cancer
Andreas Wienke, Paul Lichtenstein, Anatoli I. Yashin
We suggest a cure-mixture model to analyze bivariate time-to-event data, as motivated by the paper of Chatterjee and Shih (2001, Biometrics 57, 779 - 786), but with a simpler estimation procedure and...
A Bayesian correlated frailty model applied to Swedish breast cancer data
Isabella Locatelli, Paul Lichtenstein, Anatoli I. Yashin
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Svetlana V. Ukraintseva, Anatoli I. Yashin
Analysis of data on cancer incidence rates in different countries at different time periods revealed positive association between overall cancer risk and economic progress. Typical explanations of...
Season of birth influences life span of Mediterranean fruit flies, rats and mice
Anna V. Semenchenko, Gabriele Doblhammer, Vladimir N. Anisimov, James R. Carey, Anatoli I. Yashin
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Modeling of immune life history and body growth: the role of antigen burden
Sergey G. Rudnev, Alexei A. Romanyukha, Anatoli I. Yashin
In this paper, a recently developed mathematical model of age related changes in population of peripheral T cells (Romanyukha, Yashin, 2003) is used to describe ontogenetic changes of the immune...
Individual fecundity dynamically predicts remaining life expectancy in medflies
Vassili N. Novoseltsev, James R. Carey, Janna A. Novoseltseva, Anatoli I. Yashin
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Dependent Hazards in Multivariate Survival Problems
Yashin, Anatoli I., Iachine, Ivan A.
A new class of bivariate survival distributions is constructed from a given family of survival distributions. The properties of these distributions are analyzed. It is shown that the same bivariate...