André Oberthuer

Co-regulated expression of HAND2and DEINby a bidirectional promoter with asymmetrical activity in neuroblastoma (2009)

Voth, Harald, Oberthuer, André, Simon, Thorsten, Kahlert, Yvonne, Berthold, Frank, Fischer, Matthias

Abstract Background HAND2 , a key regulator for the development of the sympathetic nervous system, is located on chromosome 4q33 in a head-to-head orientation with DEIN , a recently identified novel...

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas (2008)

Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, ...

Abstract Background Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy...

Featured Article The Tumor-Associated Antigen PRAME Is Universally Expressed in High-Stage Neuroblastoma and Associated with Poor Outcome (2008)

André Oberthuer, Barbara Hero, Rüdiger Spitz, Frank Berthold, Matthias Fischer

Purpose: The tumor-associated antigen PRAME, a potential candidate for immunotherapeutic targeting, is frequently expressed in a variety of cancers. However, no information about its presence in...

Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes (2007)

Warnat, Patrick, Oberthuer, André, Fischer, Matthias, Westermann, Frank, Eils, Roland, Brors, Benedikt

Abstract Background Neuroblastoma patients show heterogeneous clinical courses ranging from life-threatening progression to spontaneous regression. Recently, gene expression profiles of neuroblastoma...

Gene-expression based classification of neuroblastoma patients using a customized oligonucleotide-microarray outperforms current clinical risk stratification (2006)

Oberthuer, André, Berthold, Frank, Warnat, Patrick, Hero, Barbara, Kahlert, Yvonne, Spitz, Rüdiger, ...

PURPOSE: To develop a gene expression–based classifier for neuroblastoma patients that reliably predicts courses of the disease. PATIENTS AND METHODS: Two hundred fifty-one neuroblastoma specimens...

Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes

Warnat, Patrick, Oberthuer, André, Fischer, Matthias, Westermann, Frank, Eils, Roland, Brors, Benedikt

Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma

Voth, Harald, Oberthuer, André, Simon, Thorsten, Kahlert, Yvonne, Berthold, Frank, Fischer, Matthias

Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

Westermann, Frank, Muth, Daniel, Benner, Axel, Bauer, Tobias, Henrich, Kai-Oliver, Oberthuer, André, ...

Differences in MYCN/c-MYC target gene expression are associated with distinct neuroblastoma subtypes and clinical outcome.