André Scherag

Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups (2009)

Vogel, Carla IG, Scherag, André, Brönner, Günter, Nguyen, Thuy T, Wang, Hai-Jun, Grallert, Harald, ...

Abstract Background Gastric inhibitory polypeptide (GIP) is postulated to be involved in type 2 diabetes mellitus and obesity. It exerts its function through its receptor, GIPR. We genotyped three...

Non-replication of an association of CTNNBL1polymorphisms and obesity in a population of Central European ancestry (2009)

Vogel, Carla IG, Greene, Brandon, Scherag, André, Müller, Timo D, Friedel, Susann, Grallert, Harald, ...

Abstract Background A recent genome-wide association (GWA) study of U.S. Caucasians suggested that eight single nucleotide polymorphisms (SNPs) in CTNNBL1 are associated with obesity and increased...

Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa (2008)

Müller, Timo, Reichwald, Kathrin, Brönner, Günter, Kirschner, Jeanette, Nguyen, Thuy, Scherag, André, ...

Abstract Background Several lines of evidence indicate that the central cannabinoid receptor 1 (CNR1) as well as the major endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH),...

'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents (2008)

Müller, Timo D, Hinney, Anke, Scherag, André, Nguyen, Thuy T, Schreiner, Felix, Schäfer, Helmut, ...

Abstract Background We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within...

Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia (2008)

Knoll, Susanne, Zimmer, Sabiene, Hinney, Anke, Scherag, André, Neubauer, Andreas, Hebebrand, Johannes

Abstract Background At present pathogenic mechanisms of cancer cachexia are poorly understood. Previous evidence in animal models implicates the melanocortin-4 receptor gene ( MC4R ) in the...

Design adaptation methods for genetic association studies (2008)

Scherag, André

Genetische Assoziationsstudien stellen eine häufig verwendete Methode zur Identifikation von Suszeptibilitätsgenen komplexer Erkrankungen (z.B. Asthma, Adipositas, Brustkrebs) dar. Um bei diesen...

Comparison of the power of haplotype-based versus single- and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis (2007)

Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy, Schäfer, Helmut, ...

Abstract Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect...

Mutation screen and association studies in the Diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13 (2007)

Friedel, Susann, Reichwald, Kathrin, Scherag, André, Brumm, Harald, Wermter, Anne-Kathrin, Fries, Hans-Rudolf, ...

Abstract Background DGAT2 is a promising candidate gene for obesity because of its function as a key enzyme in fat metabolism and because of its localization on chromosome 11q13, a linkage region for...

Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3gene in extremely obese children and adolescents (2007)

Hölter, Katja, Wermter, Anne-Kathrin, Scherag, André, Siegfried, Wolfgang, Goldschmidt, Hanspeter, Hebebrand, Johannes, ...

Abstract Background The suppressor of cytokine signaling (SOCS)-3 is a negative feedback regulator of cytokine signaling and also influences leptin signaling. We investigated association of...

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts (2007)

Helen N. Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, Xiaofeng Zhu, ...

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...

Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room – implications for the treatment of PONV and related clinical trials (2006)

Eberhart, Leopold HJ, Frank, Silke, Lange, Henning, Morin, Astrid M, Scherag, André, Wulf, Hinnerk, ...

Abstract Background Despite the presence of a plethora of publications on the prevention of postoperative nausea and vomiting (PONV) only little is known how to treat established symptoms. Besides...

Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome wide linkage study and subsequent association studies (2006)

Dempfle, Astrid, Wudy, Stefan A., Saar, Kathrin, Hagemann, Sandra, Friedel, Susann, Scherag, André, ...

Stature is a highly heritable trait under both polygenic and major gene control. We aimed to identify genetic regions linked to idiopathic short stature (ISS) in childhood, through a whole genome...

Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies (2006)

Dempfle, Astrid, Wudy, Stefan A., Saar, Kathrin, Hagemann, Sandra, Friedel, Susann, Scherag, André, ...

Stature is a highly heritable trait under both polygenic and major gene control. We aimed to identify genetic regions linked to idiopathic short stature (ISS) in childhood, through a whole genome...

Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity (2005)

Michael M. Swarbrick, Björn Waldenmaier, Len A. Pennacchio, Denise L. Lind, Martha M. Cavazos, Frank Geller, ...

A large genetic study involving multiple populations is not able to replicate previous findings linking variation in the GAD2 gene to susceptibility to obesity.

Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity (2005)

Michael M. Swarbrick, Björn Waldenmaier, Len A. Pennacchio, Denise L. Lind, Martha M. Cavazos, Frank Geller, ...

The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these...

Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity

Swarbrick, Michael M, Waldenmaier, Björn, Pennacchio, Len A, Lind, Denise L, Cavazos, Martha M, Geller, Frank, ...

The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these...

Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room – implications for the treatment of PONV and related clinical trials

Eberhart, Leopold HJ, Frank, Silke, Lange, Henning, Morin, Astrid M, Scherag, André, Wulf, Hinnerk, ...

Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity

Swarbrick, Michael M, Waldenmaier, Björn, Pennacchio, Len A, Lind, Denise L, Cavazos, Martha M, Geller, Frank, ...

The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these...

The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts

Lyon, Helen N, Emilsson, Valur, Hinney, Anke, Heid, Iris M, Lasky-Su, Jessica, Zhu, Xiaofeng, ...

A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI...

Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents

Hölter, Katja, Wermter, Anne-Kathrin, Scherag, André, Siegfried, Wolfgang, Goldschmidt, Hanspeter, Hebebrand, Johannes, ...

Mutation screen and association studies in the Diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13

Friedel, Susann, Reichwald, Kathrin, Scherag, André, Brumm, Harald, Wermter, Anne-Kathrin, Fries, Hans-Rudolf, ...

Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants

Hinney, Anke, Nguyen, Thuy Trang, Scherag, André, Friedel, Susann, Brönner, Günter, Müller, Timo Dirk, ...

Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia

Knoll, Susanne, Zimmer, Sabiene, Hinney, Anke, Scherag, André, Neubauer, Andreas, Hebebrand, Johannes

Comparison of the power of haplotype-based versus single- and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis

Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy Trang, Schäfer, Helmut, ...

Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect modifiers. The...

'Fat mass and obesity associated' gene (FTO): No significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents

Müller, Timo D, Hinney, Anke, Scherag, André, Nguyen, Thuy T, Schreiner, Felix, Schäfer, Helmut, ...

Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa

Müller, Timo Dirk, Reichwald, Kathrin, Brönner, Günter, Kirschner, Jeanette, Nguyen, Thuy Trang, Scherag, André, ...

Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups

Vogel, Carla IG, Scherag, André, Brönner, Günter, Nguyen, Thuy T, Wang, Hai-Jun, Grallert, Harald, ...

Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry

Vogel, Carla IG, Greene, Brandon, Scherag, André, Müller, Timo D, Friedel, Susann, Grallert, Harald, ...