Andrés J. García

Male Fertility in Natural Populations of Red Deer Is Determined by Sperm Velocity and the Proportion of Normal Spermatozoa1 (2005)

Aurelio F. Malo, J. Julián Garde, Ana J. Soler, Andrés J. García, Montserrat Gomendio

Male reproductive success is determined by the ability of males to gain sexual access to females and by their ability to fertilize ova. Among polygynous mammals, males differ markedly in their...

Modulation of Cell Proliferation and Differentiation through Substrate-dependent Changes in Fibronectin Conformation

García, Andrés J., Vega, María D., Boettiger, David

Integrin-mediated cell adhesion to extracellular matrices provides signals essential for cell cycle progression and differentiation. We demonstrate that substrate-dependent changes in the...

Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation

Keselowsky, Benjamin G., Collard, David M., García, Andrés J.

Biomaterial surface chemistry has profound consequences on cellular and host responses, but the underlying molecular mechanisms remain poorly understood. Using self-assembled monolayers as model...

Cell Adhesion Strengthening: Contributions of Adhesive Area, Integrin Binding, and Focal Adhesion Assembly

Gallant, Nathan D., Michael, Kristin E., García, Andrés J.

Mechanical interactions between a cell and its environment regulate migration, contractility, gene expression, and cell fate. We integrated micropatterned substrates to engineer adhesive area and a...

Modulation of Cell Proliferation and Differentiation through Substrate-dependent Changes in Fibronectin Conformation

García, Andrés J., Vega, María D., Boettiger, David

Integrin-mediated cell adhesion to extracellular matrices provides signals essential for cell cycle progression and differentiation. We demonstrate that substrate-dependent changes in the...

Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation

Keselowsky, Benjamin G., Collard, David M., García, Andrés J.

Biomaterial surface chemistry has profound consequences on cellular and host responses, but the underlying molecular mechanisms remain poorly understood. Using self-assembled monolayers as model...

Cell Adhesion Strengthening: Contributions of Adhesive Area, Integrin Binding, and Focal Adhesion Assembly

Gallant, Nathan D., Michael, Kristin E., García, Andrés J.

Mechanical interactions between a cell and its environment regulate migration, contractility, gene expression, and cell fate. We integrated micropatterned substrates to engineer adhesive area and a...

Engineering graded tissue interfaces

Phillips, Jennifer E., Burns, Kellie L., Le Doux, Joseph M., Guldberg, Robert E., García, Andrés J.

Interfacial zones between tissues provide specialized, transitional junctions central to normal tissue function. Regenerative medicine strategies focused on multiple cell types and/or bi/tri-layered...

Focal Adhesion Kinase Modulates Cell Adhesion Strengthening via Integrin Activation

Michael, Kristin E., Dumbauld, David W., Burns, Kellie L., Hanks, Steven K., García, Andrés J.

Focal adhesion kinase (FAK) is an essential nonreceptor tyrosine kinase regulating cell migration, adhesive signaling, and mechanosensing. Using FAK-null cells expressing FAK under an inducible...

Anti-Inflammatory Polymeric Coatings for Implantable Biomaterials and Devices

Bridges, Amanda W., García, Andrés J.

Synthetic polymer coatings are used extensively in modern medical devices and implants because of their material versatility and processability. These coatings are designed for specific applications...