Andras Varro

Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases (2009)

Gaborit, Nathalie, Wichter, Thomas, Varro, Andras, Szuts, Viktoria, Lamirault, Guillaume, Eckardt, Lars, ...

Aims Brugada syndrome is an inherited sudden-death arrhythmia syndrome. Na+-current dysfunction is central, but mutations in the SCN5A gene (encoding the cardiac Na+-channel Nav1.5) are present in...

Pharmacological inhibition of Na/Ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block (2008)

Holemans, Patricia, Vinet, Laurent, Mercadier, Jean-Jacques, Varro, Andras, ...

Block of Na/Ca exchange (NCX) has potential therapeutic applications, in particular, if a mode-selective block could be achieved, but also carries serious risks for disturbing the normal Ca2+ balance...

Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium (2005)

Szentadrassy, Norbert, Banyasz, Tamas, Biro, Tamas, Szabo, Gergely, Toth, Balazs I., Magyar, Janos, ...

Objectives: The aim of the present study was to compare the apico–basal distribution of ion currents and the underlying ion channel proteins in canine and human ventricular myocardium. Methods: Ion...

Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts

Zicha, Stephen, Xiao, Ling, Stafford, Sara, Cha, Tae Joon, Han, Wei, Varro, Andras, ...

The transient outward current (Ito), an important contributor to transmural electrophysiological heterogeneity, is significantly remodelled in congestive heart failure (CHF). The molecular bases of...

Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts

Zicha, Stephen, Xiao, Ling, Stafford, Sara, Cha, Tae Joon, Han, Wei, Varro, Andras, ...

The transient outward current (Ito), an important contributor to transmural electrophysiological heterogeneity, is significantly remodelled in congestive heart failure (CHF). The molecular bases of...

Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart

Gaborit, Nathalie, Le Bouter, Sabrina, Szuts, Viktoria, Varro, Andras, Escande, Denis, Nattel, Stanley, ...

The various cardiac regions have specific action potential properties appropriate to their electrical specialization, resulting from a specific pattern of ion-channel functional expression. The...