Nikos Yannoutsos, Andre Nussenzweig, Patrick Wilson, Howard Petrie, Wong Yu, Hua Tang Chen, ...
Assembly of T cell receptor (TCR) �/ � genes by variable/diversity/joining (V[D]J) rearrangement is an ordered process beginning with recombination activating gene ( RAG) expression and TCR�...
Kuznetsov, Sergey, Pellegrini, Manuela, Shuda, Kristy, Fernandez-Capetillo, Oscar, Liu, Yilun, Martin, Betty K., ...
RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA repair by homologous recombination. In mice, it is essential for viability. Therefore, we have...
In vitro V(D)J recombination: Signal joint formation (1996)
Cortes, Patricia, Weis-Garcia, Frances, Misulovin, Ziva, Nussenzweig, Andre, Lai, Jiann-Shiun, Li, Gloria, ...
The first step of V(D)J recombination, specific cleavage at the recombination signal sequence (RSS), can be carried out by the recombination activating proteins RAG1 and RAG2. In vivo, the cleaved...
In vitro V(D)J recombination: Signal joint formation
Cortes, Patricia, Weis-Garcia, Frances, Misulovin, Ziva, Nussenzweig, Andre, Lai, Jiann-Shiun, Li, Gloria, ...
The first step of V(D)J recombination, specific cleavage at the recombination signal sequence (RSS), can be carried out by the recombination activating proteins RAG1 and RAG2. In vivo, the cleaved...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
In vitro V(D)J recombination: Signal joint formation
Cortes, Patricia, Weis-Garcia, Frances, Misulovin, Ziva, Nussenzweig, Andre, Lai, Jiann-Shiun, Li, Gloria, ...
The first step of V(D)J recombination, specific cleavage at the recombination signal sequence (RSS), can be carried out by the recombination activating proteins RAG1 and RAG2. In vivo, the cleaved...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
Kuznetsov, Sergey, Pellegrini, Manuela, Shuda, Kristy, Fernandez-Capetillo, Oscar, Liu, Yilun, Martin, Betty K., ...
RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA repair by homologous recombination. In mice, it is essential for viability. Therefore, we have...
53BP1 is required for class switch recombination
Ward, Irene M., Olaru, Alexandru, Minn, Kay, Tamada, Koji, Lau, Julie S., ...
53BP1 participates early in the DNA damage response and is involved in cell cycle checkpoint control. Moreover, the phenotype of mice and cells deficient in 53BP1 suggests a defect in DNA repair...
Chromosomal reinsertion of broken RSS ends during T cell development
Curry, John D., Schulz, Danae, Guidos, Cynthia J., Danska, Jayne S., Nutter, Lauryl, Nussenzweig, Andre, ...
The V(D)J recombinase catalyzes DNA transposition and translocation both in vitro and in vivo. Because lymphoid malignancies contain chromosomal translocations involving antigen receptor and...
Ishii, Ken J., Takeshita, Fumihiko, Gursel, Ihsan, Gursel, Mayda, Conover, Jacqueline, Nussenzweig, Andre, ...
Unmethylated CpG motifs present in bacterial DNA stimulate a strong innate immune response. There is evidence that DNA-dependent protein kinase (DNA-PK) mediates CpG signaling. Specifically,...
Bhandoola, Avinash, Dolnick, Benjamin, Fayad, Nihal, Nussenzweig, Andre, Singer, Alfred
Immature CD4+CD8+ thymocytes rearrange their T cell receptor (TCR)-α gene locus to generate clonotypic α/β TCR, after which a few cells expressing selectable TCR are signaled to further...
The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo
Yannoutsos, Nikos, Wilson, Patrick, Yu, Wong, Chen, Hua Tang, Nussenzweig, Andre, Petrie, Howard, ...
Assembly of T cell receptor (TCR)α/β genes by variable/diversity/joining (V[D]J) rearrangement is an ordered process beginning with recombination activating gene (RAG) expression and TCRβ...
Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo
Ouyang, Honghai, Nussenzweig, Andre, Kurimasa, Akihiro, Soares, Vera Da Costa, Li, Xiaoling, Cordon-Cardo, Carlos, ...
Ku is a complex of two proteins, Ku70 and Ku80, and functions as a heterodimer to bind DNA double-strand breaks (DSB) and activate DNA-dependent protein kinase. The role of the Ku70 subunit in DNA...
Kawauchi, Shimako, Calof, Anne L., Santos, Rosaysela, Lopez-Burks, Martha E., Young, Clint M., Hoang, Michelle P., ...
Cornelia de Lange Syndrome (CdLS) is a multi-organ system birth defects disorder linked, in at least half of cases, to heterozygous mutations in the NIPBL gene. In animals and fungi, orthologs of...